DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and ncam2

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_571905.1	Gene:	ncam2 / 114441	ZFINID:	ZDB-GENE-010822-1	Length:	795	Species:	Danio rerio

Alignment Length:	398	Identity:	85/398 - (21%)
Similarity:	142/398 - (35%)	Gaps:	156/398 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAW------LRVDTQTILTIQNHVITKN 95
            |||:.|.. |||:     ||                 |:|      :..||:....:||:
Zfish   131 AEVVCDVT-SSPV-----PV-----------------VSWFYNNIEITEDTEKFELLQNN----- 167

  Fly    96 QRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVV----VPPDILDYPTSTDM 156
                         .::::.:.::|:|.|.|:...: .:.::.:.:::    |||.:.....|.:.
Zfish   168 -------------NLQVQKVTKADEGVYRCEARVE-ARGEIDFRNIILVVNVPPVVSVPQQSFNA 218

  Fly   157 VVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEE-VMSIEGTDLVIPNVRRHHMGAYLCI 220
            ....|.:||..|.|.|||||.:||.|:.   ::|...|. ||...||.|.:.|:::...|:|.|.
Zfish   219 TADYGESVTFTCRAYGSPEPDVTWHRKG---VQLQESERYVMRARGTTLTVRNIQQDDGGSYTCR 280

  Fly   221 ASNGVPPSVSKRITLVVHFPPMIT-VQNQLIGAVEGKGVTLDCESEAYPKSINYWTR-------E 277
            |||.. ..|...:.|.|...|.|| ::|  :.||||....:.|::|..|.....|.|       .
Zfish   281 ASNKA-GEVEHELFLKVFVQPHITKLRN--VTAVEGSAAMISCKAEGEPLPEISWRRASDGHSFS 342

  Fly   278 RGEIVPPG-----GKYSAN-------------------VTEIGGYRNSM---------------- 302
            .|:..|.|     |:|..:                   ::.|||::.||
Zfish   343 DGDKSPDGRVEVRGRYGESMLTIVVVKLSDWGRFDCEALSRIGGHQKSMFLDIEYAPKFQANHTI 407

  Fly   303 -------------------------------------------------RLHINPLTQAEFGSYR 318
                                                             .|.:.|::..:||.|.
Zfish   408 FFSWEGNPVNISCDVMSNPPATMLWRREKLTIPSEGAGNMRVYTAPGRSLLEVTPMSDRDFGRYN 472

  Fly   319 CVAKNSLG 326
            |.|:|::|
Zfish   473 CTARNNIG 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	12/95 (13%)
		IG_like	51..137	CDD:214653	12/91 (13%)
		IG_like	153..237	CDD:214653	30/84 (36%)
		Ig	161..224	CDD:299845	26/63 (41%)
		IG_like	252..335	CDD:214653	28/171 (16%)
		Ig	258..333	CDD:143165	24/165 (15%)
ncam2	NP_571905.1	Ig1_NCAM-2	20..111	CDD:143274
		I-set	21..110	CDD:254352
		IGc2	127..187	CDD:197706	19/96 (20%)
		Ig	213..299	CDD:299845	31/89 (35%)
		I-set	213..296	CDD:254352	30/86 (35%)
		Ig	298..395	CDD:299845	23/98 (23%)
		I-set	300..393	CDD:254352	23/94 (24%)
		IG_like	411..488	CDD:214653	9/70 (13%)
		IGc2	412..480	CDD:197706	8/67 (12%)
		FN3	494..586	CDD:238020
		fn3	<616..675	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010