DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and col20a1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_031750574.1	Gene:	col20a1 / 101731976	XenbaseID:	XB-GENE-6047460	Length:	1361	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	87/464 - (18%)
Similarity:	154/464 - (33%)	Gaps:	134/464 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCV-------VQDLGPYKVAWLRV----DTQTILTI 87
            ::...::.|....||:      ||:.|...||       .::||.:.||...:    .:.|.|.:
Frog   372 DLTVHIVADFPLLSPL------VGQVARALCVRLKVKRREEELGAHSVALQDLADPHPSPTHLVV 430

  Fly    88 QNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTD---------PMKSQMGYLDVVV 143
             :.|..|:.|:......|:....||  :....:|....::..|         .:.|:..||..|.
Frog   431 -SEVTAKSMRLSWTPPHHQVRKYRI--VYYPSRGGTPQEVVLDGAASTSVLSNLTSRTDYLVSVF 492

  Fly   144 P---------------------PDILDYPTSTDMVV-------REGSNVTLKCAATGSPEPTITW 180
            |                     |..|:....||..:       .|.:...:.|||...
Frog   493 PIYGSGVGSGLRGITSTLPLPAPRSLEAEQVTDTTIGLRWHASEEAAQYLVLCAAQSD------- 550

  Fly   181 RRESGVPIELATGEEVMSIEGTDLVIPNV---RRHHMGAYLCIASNGVPPSVSKRITLVVHFPPM 242
                  |:|.|:  || .:.||::::..:   ..:.:..|.........||..::||     .|.
Frog   551 ------PVEKAS--EV-KVAGTEVLLSGLAPSTHYSLTVYAVSGDEMSDPSFLQQIT-----EPP 601

  Fly   243 ITVQNQLIGAVEGKGVTLDCE---SEAYPKSINYWT------RERGEIVPPGGKYSANVTEIGGY 298
            :..::.....|....|.:..:   |:..|..::|..      |:..|:  |||  |::||
Frog   602 VPPRDLRFSEVAHSSVAVHWQSPSSDGKPHRVSYSPAPGSSGRQEEEV--PGG--SSSVT----- 657

  Fly   299 RNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRIPPNAVNYVENFEARHKGKKRTKSSES 363
                   :..|....|.|......:. |...|.:...::||..     .....|....|.|::..
Frog   658 -------LKSLLSQTFYSVTVTGWHG-GAVTGNVTTLKVPPPT-----GLSVTHLSGDRAKATWD 709

  Fly   364 HHPARAQEH-------SGEDMEN---PGKRKADLSLGAE-------SIDSIY-----GNSAAGSR 406
            ........:       ||..:..   ||.:|..|..|.|       ||.::|     .::::|..
Frog   710 QGEPDVTSYLIKWMPLSGGKLSQVSVPGGQKMALLSGMEYNTEYQVSISALYVDGALSDASSGRY 774

  Fly   407 RRQDLGGVL 415
            |.:.|.|.|
Frog   775 RTEVLPGKL 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	22/109 (20%)
		IG_like	51..137	CDD:214653	20/105 (19%)
		IG_like	153..237	CDD:214653	18/93 (19%)
		Ig	161..224	CDD:299845	11/65 (17%)
		IG_like	252..335	CDD:214653	18/91 (20%)
		Ig	258..333	CDD:143165	17/83 (20%)
col20a1	XP_031750574.1	fn3	27..99	CDD:394996
		vWA_collagen_alphaI-XII-like	219..381	CDD:238759	0/8 (0%)
		FN3	425..500	CDD:238020	15/77 (19%)
		fn3	513..592	CDD:394996	16/94 (17%)
		FN3	601..>672	CDD:238020	16/86 (19%)
		fn3	689..764	CDD:394996	16/79 (20%)
		LamG	813..1007	CDD:419873
		Collagen	1061..1116	CDD:396114
		Collagen	1126..1194	CDD:396114
		Collagen	1294..>1341	CDD:396114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910