DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and igsf9b

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_031761656.1	Gene:	igsf9b / 100379858	XenbaseID:	XB-GENE-5887265	Length:	1392	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	117/486 - (24%)
Similarity:	177/486 - (36%)	Gaps:	120/486 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TCALSVILLLILMSQQCYPQRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTC-VVQDL----GP 71
            |...|||..|.|..|.....|.|        |:|      :||..|....|.| ||..|    .|
Frog     7 TLIASVISTLGLSVQGAGGSREE--------PQF------VTARAGESVILGCDVVHPLTVQPPP 57

  Fly    72 YKVAWLRVDTQTILTIQ-----NHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQI---- 127
            |.|.|.:......:.|:     .||  ..:.:|.|....|. ::||:.::..|:|||.|::
Frog    58 YVVEWFKFGVPIPIFIKFGFYPPHV--DPEYVGRAALYDKA-SLRIEQVRSQDQGWYECKVLMLE 119

  Fly   128 -NTDPM-KSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIEL 190
             ..|.. .....:|.|..||...:.|... :.|:|||::||.|.|.|:|:||::|.||.    |.
Frog   120 HQYDTFHNGSWVHLTVNAPPTFTETPPQY-LEVKEGSSITLTCTAFGNPKPTVSWLREG----EF 179

  Fly   191 ATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEG 255
            ........:....|.|.::.|...|:|:|.|:: :.........|:|...|.|....:.|.....
Frog   180 LGRTSKYQLSDGSLTISSIGREDRGSYMCRATS-IQGEAVHSTRLLVQGSPFIVSPPENITVNIS 243

  Fly   256 KGVTLDCESEAYPKSIN---YWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQA----- 312
            :.....|::||||.::.   ||..|             ||.    ::|.::|.:..|...
Frog   244 QDALFTCQAEAYPGNLTYTWYWQEE-------------NVF----FKNDLKLRVRILIDGTLIIF 291

  Fly   313 -----EFGSYRCVAKNSLGDTDGT---------IKLYRIPPNAVNYVENFEARHKGKKR------ 357
                 :.|.|.||..||||.:...         .::..:||  |.||   .....|..|
Frog   292 RVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVVNMPP--VIYV---PVGIHGHIRCPVEAV 351

  Fly   358 -----TKSSESHHPARAQEHSGEDMENPG----KRKADLSLGAESI------------------- 394
                 .|.::...|.|..:.||..:.:.|    :...:..||..:.
Frog   352 PPVTFVKWNKDGRPLRIDKFSGWKLLDDGTIHVEEATEELLGTYTCVPYNALGTMGQSPPARLLL 416

  Fly   395 -DSIYGNSAAGSRRRQDLGGVLLLLLPVAVA 424
             |..|.....|...||:.|..  ||:|.|.|
Frog   417 KDPPYFTVLPGWEYRQEAGRE--LLIPCAAA 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	27/105 (26%)
		IG_like	51..137	CDD:214653	26/101 (26%)
		IG_like	153..237	CDD:214653	24/83 (29%)
		Ig	161..224	CDD:299845	21/62 (34%)
		IG_like	252..335	CDD:214653	21/104 (20%)
		Ig	258..333	CDD:143165	21/96 (22%)
igsf9b	XP_031761656.1	IG	30..115	CDD:214652	27/93 (29%)
		I-set	139..225	CDD:400151	26/91 (29%)
		Ig strand A	139..142	CDD:409353	1/2 (50%)
		Ig strand A'	148..151	CDD:409353	0/3 (0%)
		Ig strand B	157..164	CDD:409353	3/6 (50%)
		Ig strand C	170..175	CDD:409353	2/4 (50%)
		Ig strand D	185..189	CDD:409353	0/3 (0%)
		Ig strand E	191..195	CDD:409353	1/3 (33%)
		Ig strand F	204..212	CDD:409353	4/7 (57%)
		Ig strand G	215..225	CDD:409353	1/9 (11%)
		I-set	229..321	CDD:400151	24/108 (22%)
		Ig strand B	246..250	CDD:409353	0/3 (0%)
		Ig strand C	260..264	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	0/3 (0%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
		Ig strand G	314..317	CDD:409353	0/2 (0%)
		Ig	344..405	CDD:409353	9/60 (15%)
		Ig strand C	355..360	CDD:409353	1/4 (25%)
		Ig strand E	380..384	CDD:409353	1/3 (33%)
		Ig strand F	394..399	CDD:409353	0/4 (0%)
		Ig	429..505	CDD:416386	8/19 (42%)
		Ig strand A'	429..432	CDD:409353	0/2 (0%)
		Ig strand B	438..445	CDD:409353	4/6 (67%)
		Ig strand C	451..456	CDD:409353
		Ig strand C'	458..460	CDD:409353
		Ig strand E	471..476	CDD:409353
		Ig strand F	484..492	CDD:409353
		Ig strand G	495..505	CDD:409353
		FN3	510..605	CDD:238020
		FN3	622..703	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910