DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and lrit3b

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_009305418.1	Gene:	lrit3b / 100144406	ZFINID:	ZDB-GENE-070424-130	Length:	487	Species:	Danio rerio

Alignment Length:	345	Identity:	59/345 - (17%)
Similarity:	117/345 - (33%)	Gaps:	119/345 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 VQDLGPYKVAWLRVDTQTILTIQNHV---ITKNQRIGIANSEHKTW-------TMRIKDIKESDK 120
            ::.||.:.....|:....:..::|..   ::.|:...:||.....|       |.|...:...|.
Zfish   162 LRTLGLHNNRLARIPLLAVRYLRNVTYLDLSSNRLSTLANDLTALWLFSDSNQTQRSFVLGLQDN 226

  Fly   121 GWYM-CQINT------DPMKSQM---GYLDVVVPPDILDYP----------------TSTDMVVR 159
            .|.. |:::|      .|..|.:   .:|....|.|:...|                ::|.:...
Zfish   227 PWVCDCRLSTLLDISRGPESSLVLLDRFLTCSEPLDLAGVPFQSVELSRCRRPYVVTSATKITAL 291

  Fly   160 EGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNG 224
            .||.|.|:|.|||.|.|.:.|                         |.:.:|:
Zfish   292 LGSTVLLRCEATGHPTPALMW-------------------------IKSAKRN------------ 319

  Fly   225 VPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYS 289
                                :.||  |..:....:||  :|.:||.:..:.:|...:
Zfish   320 --------------------LYNQ--GCCKQTQSSLD--TERFPKKLFGYVQESPRV-------- 352

  Fly   290 ANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRIPPNAVNYVENF-EARHK 353
                   |.|.|: :.:|.::.::.|.|||.|:|..|.::..:.|     |.|..:..: :.::.
Zfish   353 -------GVRWSV-VSLNGISYSDAGEYRCRAQNMAGISEAVVSL-----NVVGVMAEYTDFKNS 404

  Fly   354 GKKRTKSSESHHPARAQEHS 373
            .:::|.:.......:.::.|
Zfish   405 DQQQTTTKSDSKRTKPKQKS 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	17/94 (18%)
		IG_like	51..137	CDD:214653	16/90 (18%)
		IG_like	153..237	CDD:214653	14/83 (17%)
		Ig	161..224	CDD:299845	13/62 (21%)
		IG_like	252..335	CDD:214653	17/82 (21%)
		Ig	258..333	CDD:143165	17/74 (23%)
lrit3b	XP_009305418.1	LRRNT	51..92	CDD:214470
		leucine-rich repeat	69..89	CDD:275380
		LRR_8	112..172	CDD:290566	2/9 (22%)
		leucine-rich repeat	114..137	CDD:275378
		leucine-rich repeat	138..161	CDD:275378
		LRR_8	160..214	CDD:290566	8/51 (16%)
		LRR_4	160..201	CDD:289563	5/38 (13%)
		leucine-rich repeat	162..185	CDD:275378	3/22 (14%)
		leucine-rich repeat	186..199	CDD:275378	1/12 (8%)
		leucine-rich repeat	215..230	CDD:275378	4/14 (29%)
		Ig	278..391	CDD:299845	35/194 (18%)
		I-set	279..391	CDD:254352	35/193 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900