DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and negr1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_031755650.1	Gene:	negr1 / 100127726	XenbaseID:	XB-GENE-987949	Length:	388	Species:	Xenopus tropicalis

Alignment Length:	380	Identity:	118/380 - (31%)
Similarity:	183/380 - (48%)	Gaps:	43/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSNFCQCRKQTCALSVILLLILMSQQCYPQRVEVPAEVIVDPKFSSPIV-NMTAPVGRDAFLTC 64
            :|...| |..|..| :|||.|..:...|      :||...:|  |..|.| |:....|..|.|.|
Frog     7 VQGAAC-CSNQWLA-AVILSLCCLLPSC------LPAGQSMD--FQWPAVDNLVVRQGETAMLRC 61

  Fly    65 VVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINT 129
            .::: |..|.|||  :..:|:.......:.:.|:.||.|..:.:::||:.:..||.|.|.|.:.|
Frog    62 FLEE-GASKGAWL--NRSSIIFAGGDKWSVDPRVSIATSSKQEYSLRIQKVDVSDDGPYTCSVQT 123

  Fly   130 D--PMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELAT 192
            :  |...|: :|.|.|.|.|  |..|:||.|.||:||:|.|.|||.|||:|:||..|....:..:
Frog   124 EHSPRTLQV-HLTVHVSPKI--YDISSDMTVNEGTNVSLICLATGKPEPSISWRHISPSAKQFGS 185

  Fly   193 GEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVP-PSVSKRITLVVHFPPMITVQNQLIGAVEGK 256
            |:.        |.|..:.|...|.|.|.|.|.|. |.| |::.:.|:|.|.| ::....|...|:
Frog   186 GQY--------LDIYGITRDQAGDYECSAENDVSFPDV-KKVKVTVNFAPTI-LEITPTGVSLGR 240

  Fly   257 GVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVA 321
            ...:.||:.|.|..:..|  .:||.....|:..   ..|..|.....|.::.:|:..||:|.|||
Frog   241 TGLIRCETAAVPAPVFEW--YKGEKKLTNGQRG---IRIQNYNTRSILTVSNVTEEHFGNYTCVA 300

  Fly   322 KNSLGDTDGTIKLYR-IPPNAVNYVEN---FEARHKGKKRTKSSESHH--PARAQ 370
            .|.||.::.::.|.: |.|:..:.|.:   :..:|..  |:.|.:.|:  |:.||
Frog   301 VNKLGTSNASLPLNQIIEPSTTSPVTSSAKYSVKHYA--RSSSDKPHYAAPSTAQ 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	26/91 (29%)
		IG_like	51..137	CDD:214653	25/87 (29%)
		IG_like	153..237	CDD:214653	33/84 (39%)
		Ig	161..224	CDD:299845	23/62 (37%)
		IG_like	252..335	CDD:214653	22/82 (27%)
		Ig	258..333	CDD:143165	21/74 (28%)
negr1	XP_031755650.1	Ig	44..136	CDD:416386	28/95 (29%)
		FR1	44..62	CDD:409353	6/17 (35%)
		Ig strand A'	47..53	CDD:409353	1/5 (20%)
		Ig strand B	55..63	CDD:409353	3/7 (43%)
		CDR1	63..68	CDD:409353	1/5 (20%)
		FR2	69..75	CDD:409353	4/7 (57%)
		Ig strand C	69..74	CDD:409353	4/6 (67%)
		CDR2	76..87	CDD:409353	1/10 (10%)
		Ig strand C'	78..82	CDD:409353	1/3 (33%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		FR3	88..122	CDD:409353	11/33 (33%)
		Ig strand D	91..98	CDD:409353	3/6 (50%)
		Ig strand E	101..107	CDD:409353	1/5 (20%)
		Ig strand F	114..122	CDD:409353	3/7 (43%)
		CDR3	123..127	CDD:409353	1/3 (33%)
		Ig strand G	127..136	CDD:409353	3/9 (33%)
		FR4	129..136	CDD:409353	2/7 (29%)
		Ig_3	140..208	CDD:404760	31/77 (40%)
		Ig strand A'	146..151	CDD:409353	3/4 (75%)
		Ig strand B	157..164	CDD:409353	3/6 (50%)
		Ig strand C	170..175	CDD:409353	2/4 (50%)
		Ig strand C'	177..179	CDD:409353	1/1 (100%)
		Ig strand E	187..193	CDD:409353	2/13 (15%)
		Ig strand F	200..207	CDD:409353	3/6 (50%)
		Ig strand G	214..222	CDD:409353	2/8 (25%)
		Ig_3	226..302	CDD:404760	22/81 (27%)
		putative Ig strand A	226..232	CDD:409353	2/6 (33%)
		Ig strand B	242..246	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	1/5 (20%)
		Ig strand E	281..285	CDD:409353	1/3 (33%)
		Ig strand F	295..300	CDD:409353	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060