DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR1.3

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	1020	Identity:	216/1020 - (21%)
Similarity:	361/1020 - (35%)	Gaps:	336/1020 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAI----ASGANEDT-----LVIKIGAIFFDTEMK---LADAFSAALEEVNAINPAL 56
            |.||::|.|.|    ||..|:|.     :.|::|.:.....:|   :.::.|.||....||:
plant    12 LSFLLVLLLFISRSFASTKNDDVDGGKRVQIRVGLVLDLGSLKGKIVKNSVSMALSYFYAIH--- 73

  Fly    57 KLDAIKRYVTVD------DSIVLQDISCDLIGS-GVAAIFGPSSKTNSDIVEVLCNMTGIPHLQF 114
              :..|..|:|.      :.::....:.||:.: ||.||.|.:|...:.::..|.....:|.:..
plant    74 --NDYKTRVSVSLRNSHGEPLLALASAVDLLKTEGVEAIIGGNSLLEAKLLGELGEKARVPMISL 136

  Fly   115 DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS--------------KTFDWKSFTIAYE- 164
            |                   :|..|.||.....|.|:              ..|||.|..:.||
plant   137 D-------------------SPFSLSLSKYTHLIQATHDSTSEAKGITSFINVFDWNSVALVYED 182

  Fly   165 ----RSSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRIN---NAREKFV------LLDC 216
                |.|..:.::|      .|:.|:::|            .::.   ::.|.||      |.|.
plant   183 HDDWRESMQLLVEH------FHENGVRVQ------------SKVGFTVSSSEDFVMGRLQQLKDL 229

  Fly   217 PSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFY--------------SRDFT--VAVA 265
            .:.:.|..::..|.       .|||.......|.| |||.              ..|||  ....
plant   230 GTTVFVVHLSEVIA-------THLFPCARRLGLMG-DGFVWILTAKTMNSFHENIDDFTKQAMEG 286

  Fly   266 AVRIRTYVPPPVHDEIDVF----------DNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGF 320
            .|..::|:|..:  |:..|          :.:..||.|..|   ::...:.|  ||...::
plant   287 VVGFKSYIPMSI--ELQNFTLRWRKSLPVEEAELTRLSISG---IWAHDIAF--ALARAAE---- 340

  Fly   321 YIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNL-----EVYNPIID 380
                              |.:|..:|..:::...||:...::.|.|..|..|     |:.|.|..
plant   341 ------------------VIRMPNVTSTLLEEITKTRFNGLSGDFQLNDKKLLSNKFEIINMIGS 387

  Fly   381 ---RV-----------------TH------IW-------NKEFQLVDFE--KLRENSTQALKQKR 410
               ||                 ||      ||       .|...|:|.:  |||...|.:.:..|
plant   388 SERRVGFLNSNGSFSNRRHLSSTHNKLETIIWPGGSAQSPKGTSLIDSDRKKLRVLVTSSNRFPR 452

  Fly   411 LQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERF-EGYAVDLIYMLAQECKFDFNFE 474
            |...|   ..|:.                         ||.. ||:.:::  ..|....|::..|
plant   453 LMKVE---TDPVT-------------------------NELIVEGFCIEV--FRASISPFNYEVE 487

  Fly   475 PV-------RDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGIS 532
            .:       .||...:..:..|::|          |.:|  |:|||..|.:.||||:||.::|:.
plant   488 YIPWLNGSNYDNLAYALHSQKDKYD----------AAVG--DITITSNRSTYVDFTLPFTEMGLG 540

  Fly   533 ILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW-DQPVENVNREMERQ 596
            |::.||    ..::.|..|...::|:       .:||..:.||.|   .| .:..||    .|.|
plant   541 IVAVKE----RSMWVFFQPLTPDLWI-------TSAFFFVLTGVI---VWLIERAEN----KEFQ 587

  Fly   597 NIW--HLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLI-SQTYIAKLAAFITSSKIA 658
            ..|  .:...||....:::....:.|...|...::|.  |:||:|| :.:|.|.|.:.:|..:|.
plant   588 GSWPQQIGVVLWFGFSTLVYAHREKLKHNLSRFVVTV--WVFAVLILTASYTATLTSMMTVQQIR 650

  Fly   659 GD-----IGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGV 718
            .:     :|.|...:..|.....:......|:..:.:.|....:. ||.:||..|      |...
plant   651 FNSNEDYVGHLSGSLIANVALTSSSLRAMRSLGLNSAADYAQALL-NKTVSFVVD------ELPY 708

  Fly   719 DRVKLSKGTYAFLM----ETTN-LQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGIL 778
            .:|.|.:....|.|    .||| ..:..|:..||               ||       |:|..|.
plant   709 LKVVLGENPTHFFMVKTQSTTNGFGFMFQKGFEL---------------VP-------NVSREIS 751

  Fly   779 RLSERGELFKLRNKWFNSNESTCDSNVP-TIDD--GQFDMDSVGGLFVVLIVGVVVGLVIGVAEF 840
            :|....:|.::..:||       |:.:| |.||  ....:....|||:  |:||.....:.|...
plant   752 KLRTSEKLNEMEKRWF-------DNQLPYTTDDTSNPITLYRFRGLFI--IIGVSFAFALAVLVI 807

  Fly   841 L-----WH--VQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHT 878
            |     |.  |..:.:.:::.         :|.|.|   .:.:||
plant   808 LCLRDKWEILVDNLDLSQRLR---------HFRIHF---VRSIHT 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	88/468 (19%)
		ANF_receptor	41..378	CDD:279440	78/402 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	86/394 (22%)
		Lig_chan	555..822	CDD:278489	63/283 (22%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	83/440 (19%)
		ANF_receptor	57..385	CDD:279440	78/406 (19%)
		GluR_Plant	438..767	CDD:270404	93/419 (22%)
		Lig_chan	559..798	CDD:278489	68/292 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.920