DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	969	Identity:	188/969 - (19%)
Similarity:	338/969 - (34%)	Gaps:	259/969 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAI----ASGANEDT---------LVIKIGAI---------------FFDTEMKLAD 40
            |.||::|...|    ||..|.|.         ||:.:|::               |:|.......
plant    12 LSFLLVLLFFISNCFASSQNNDDDKRIRVRVGLVLDLGSVEGKIVRSSVSMALSDFYDNHNDYKT 76

  Fly    41 AFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCN 105
            ..|..:.:.:. .|.|.||::     ||   :||.       .||.||.|.:|...:.::..|..
plant    77 RLSLLVRDSHG-EPLLALDSV-----VD---LLQT-------EGVQAIIGGNSLLEAKLLAELGE 125

  Fly   106 MTGIPHLQFDWHPQQSNRERMNH--QLTVN----VAPMELFLSAAFSDILASKTFDWKSFTIAYE 164
            ...:|.:..: .|...:..:..|  |.|.|    |..:..||..          |||.|..:..|
plant   126 KARVPVISLN-SPMSLSLSKYTHLIQATHNSASEVKGITAFLHG----------FDWNSVALVLE 179

  Fly   165 RSSHLIRLQHILAWKQLHKAGIKMQE---FERGDDYRILWKRINNARE----KFV---------- 212
            .........|.:. ...|:..:.:|.   |........|..|:...::    .||
plant   180 DHDDWRESMHFMV-DHFHENNVHVQSKVAFSVTSSEDSLMDRLRELKDLGTTVFVVHLSEVIATR 243

  Fly   213 LLDCPSDILVDVINASIGYNMT----GSFNHLFLTNLDTH-LSGIDGFYSRDFTVAVAAVRIRTY 272
            |..|...:  .::.....:.:|    .||:..|:.:|... :.|:.||              ::|
plant   244 LFPCAEKL--GMMGEGFAWILTSRSMSSFHDQFIDDLTKEAMEGVVGF--------------KSY 292

  Fly   273 VPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGFWQ---- 333
            :|                    :..:|  .:..|.:...|.:.:..|..|...|.. |.|.
plant   293 IP--------------------MSKEL--HNFTLRWRKTLPVEEVTGSEITRLSIS-GVWAHDVA 334

  Fly   334 ---PGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNL-----EVYNPI--IDRVTHIWNK 388
               .....|.:|..:|..:::...:::...::.:.|.:|..|     |:.|.|  .:|....||.
plant   335 WSLASAAEVTRMPTVTSTLLEAIKESRFKGLSGNFQLDDMKLLSDKFEIVNMIGSGERRVGFWNS 399

  Fly   389 EFQLVDFEKLRE------------NSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEP 441
            .....:..:|..            .|.|:.|.:.|:   :..:|.:|..|.:....|.. .:.|.
plant   400 NGSFSNRRQLSSTHDNLETIIWPGGSAQSPKGRSLR---ESGRKKLRVLVTSSNRFPRL-MKVET 460

  Fly   442 EGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSY-------DANTDEWDGIIRQLI 499
            :.:.:| ....||:.:::..  |....|::..|.:|.....:|       .:..|::|
plant   461 DPITHE-ITIVEGFCIEVFQ--ASIAPFNYEVEYIRWLNGTNYTKLAYALHSQKDKYD------- 515

  Fly   500 DNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAM 564
               |.:|  |:|||..|...||||:|:.::|:.|::.||    ..::.|..|....:|:......
plant   516 ---AAVG--DITITSDRSMYVDFTLPYTEMGLGIVAAKE----RSMWVFFQPLTPNLWITSAAFF 571

  Fly   565 MITAFALIFTGRIDQYEWDQPVENVNREMERQNIW--HLSNALWLVLGSMLNQGCDLLPRGLPMR 627
            ::|.   |....|::.|        |:|.  |..|  .:...:|....:::....:.|...|...
plant   572 VLTG---IIVWLIERAE--------NKEF--QGSWPQQIGVVIWFGFSTLVYAHREKLQHNLSRF 623

  Fly   628 LLTAFWWIFALLISQT-YIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESN 691
            ::|.  |:||:||..| |.|.|.:.:|..:|.         .:.|:...|.:.|.    ..:.:.
plant   624 VVTV--WVFAVLILVTSYTATLTSMMTVQQIR---------FNANEDYVGHLSGS----LIANAA 673

  Fly   692 DTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGE 756
            .|::.:...::|..       |..|...:..::|.....:.|...|:..         :||:.|.
plant   674 LTNSSLRAMRLLGL-------NTSEDYAQALMNKSVSYIVSELPYLKIL---------LGENPGH 722

  Fly   757 ----------KHYGIAVPLNADFRSNLS--VGILRLSERGELFKLRNKWFNSNESTCDSNVP-TI 808
                      ..:|......::...|:|  :..||.|||  |.::..:||       |..:| |.
plant   723 FLMVKTQSTTNGFGFMFQKGSELAPNVSREIAKLRTSER--LNEMERRWF-------DKQLPYTT 778

  Fly   809 DD--GQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYF 865
            ||  ....:....|||  :|.||.....:.|...||..:|..:       |......||
plant   779 DDTSNPITLYRFRGLF--MITGVSFAFALAVLLILWLRERWEI-------LVNSVNIYF 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	73/423 (17%)
		ANF_receptor	41..378	CDD:279440	66/376 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	79/394 (20%)
		Lig_chan	555..822	CDD:278489	54/284 (19%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	75/432 (17%)
		ANF_receptor	55..387	CDD:279440	68/398 (17%)
		GluR_Plant	440..770	CDD:270404	79/395 (20%)
		Lig_chan	563..801	CDD:278489	59/292 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920