DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR2.1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	938	Identity:	189/938 - (20%)
Similarity:	359/938 - (38%)	Gaps:	202/938 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAIASGANEDT-----LVIKIGAIFFD-----TEMKLADAFSAALEEVNAINPALKL 58
            |.|:::..:.:....|..|     :|..||..:.:     ..|.|:|.:|:        :|..:.
plant    12 LFFVIVFLMQVGEAQNRITNVNVGIVNDIGTAYSNMTLLCINMSLSDFYSS--------HPETQT 68

  Fly    59 DAIKRYV-TVDDSIVLQDISCDLI-GSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQS 121
            ..:...| :.:|.:.....:.||| ...|.||.||.:...:..:..:...:.:|.:.:
plant    69 RLVTTVVDSKNDVVTAAAAALDLITNKEVKAILGPWTSMQAQFMIEMGQKSQVPIVTY------- 126

  Fly   122 NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHK 183
                                 :|.|..|||....: .|...|:.||.:..::.|:   .|:::..
plant   127 ---------------------SATSPSLASIRSQY-FFRATYDDSSQVHAIKEIIKLFGWREVAP 169

  Fly   184 A--------GIK------MQEFERGDDYRILWKRI--NNAREKFV------LLDCPSDI----LV 222
            .        ||.      :||.    :.||.::.:  .||.:..:      ::..|:.:    ||
plant   170 VYVDDTFGEGIMPRLTDVLQEI----NVRIPYRTVISPNATDDEISVELLRMMTLPTRVFVVHLV 230

  Fly   223 DVINA-------SIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDE 280
            :::.:       .||....|..  ..|||..|.:..|  ....:.......:.::||||.  ..|
plant   231 ELLASRFFAKATEIGLMKQGYV--WILTNTITDVLSI--MNETEIETMQGVLGVKTYVPR--SKE 289

  Fly   281 IDVFDNSVDTRF--SSLG--SQLVYDSIVLFYNALLEISQRPGFYIP-----NFS--CGRGFWQP 334
            ::.|.:....||  |.|.  ....||:......|:.|.......::.     |.|  .|.|..|.
plant   290 LENFRSRWTKRFPISDLNVYGLWAYDATTALALAIEEAGTSNLTFVKMDAKRNVSELQGLGVSQY 354

  Fly   335 GPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQL---VDFE 396
            ||:|::.:.::..:.:...|:.    ||.:.|...|.:...|....|....|.||:.|   || :
plant   355 GPKLLQTLSRVRFQGLAGDFQF----INGELQPSVFEIVNVNGQGGRTIGFWMKEYGLFKNVD-Q 414

  Fly   397 KLRENSTQALKQKRLQN---KEDFSQKPIRYTVAT-----RVGKP-------YFSWREEPEGVHY 446
            |....:|.:..|.||:.   ..|.:..|..:.:.|     ::|.|       :.....:|    .
plant   415 KPASKTTFSSWQDRLRPIIWPGDTTSVPKGWEIPTNGKRLQIGVPVNNTFQQFVKATRDP----I 475

  Fly   447 EGNERFEGYAVDLIYMLAQECKFD--FNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICD 509
            ..:..|.|:::|....:.|...:|  ::|.|.:|   |.|||       ::.|:........:.|
plant   476 TNSTIFSGFSIDYFEAVIQAIPYDISYDFIPFQD---GGYDA-------LVYQVYLGKYDAVVAD 530

  Fly   510 LTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFT 574
            .||:..|...|||::|:...|:.::...:...:.....||.|....:||..:::..|....:
plant   531 TTISSNRSMYVDFSLPYTPSGVGLVVPVKDSVRRSSTIFLMPLTLALWLISLLSFFIIGLVV--- 592

  Fly   575 GRIDQYEWDQPVEN-VNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPM----RLLTAFWW 634
                   |  .:|: ||.:.:....:.||...|.....|:     ..||...:    |::...|:
plant   593 -------W--VLEHRVNPDFDGPGQYQLSTIFWFSFSIMV-----FAPRERVLSFWARVVVIIWY 643

  Fly   635 IFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNK---VQFGTIRGGATSVYFSESNDTDNR 696
            ...|:::|:|.|.||:.:|:..:...:.:::.|:.:.:   .|...|.|......|||::
plant   644 FLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLAKGESVGYQSSFILGRLRDSGFSEAS----- 703

  Fly   697 MAWNKMLSF-KPD----AFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNC-ELTQIGESFG 755
                 ::|: .|:    ..:|...||        |..|.|||...::.::.:.| :...:...|.
plant   704 -----LVSYGSPEHCDALLSKGQAEG--------GVSAVLMEVPYVRIFLGQYCNKYKMVQTPFK 755

  Fly   756 EKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTC-------DSNVPTIDDGQF 813
            ....|...|:.:...:::|..||::.|..:..:|.|.||...:.:|       |.| |::...|.
plant   756 VDGLGFVFPIGSPLVADISRAILKVEESNKANQLENAWFKPIDESCPDPLTNPDPN-PSVSFRQL 819

  Fly   814 DMDSVGGLFVVLIVGVVVGLVIGVAEFL 841
            ..||...||:|..:...:.|:..|.:||
plant   820 GFDSFWVLFLVAAIVCTMALLKFVYQFL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	81/423 (19%)
		ANF_receptor	41..378	CDD:279440	71/385 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	79/400 (20%)
		Lig_chan	555..822	CDD:278489	58/287 (20%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	79/412 (19%)
		ANF_receptor	49..392	CDD:279440	73/393 (19%)
		GluR_Plant	452..794	CDD:270404	77/390 (20%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	48/233 (21%)
		Lig_chan	576..835	CDD:278489	61/294 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920