DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR2.6

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001330285.1	Gene:	GLR2.6 / 830988	AraportID:	AT5G11180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	976	Identity:	187/976 - (19%)
Similarity:	341/976 - (34%)	Gaps:	305/976 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALK-----LDAIKR 63
            :.|||||     ..:.::.|.:::| |..||...|     ||| .:.|||.:|.     .:..|.
plant    20 INFLVLL-----GKSQQEVLQVQVG-IVLDTNATL-----AAL-SLRAINMSLSEFYNTHNGFKT 72

  Fly    64 YVTVDDSIVLQDISCDLIGSG-----------VAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWH 117
            .:.::    ::|....::|:.           |.||.||.:...:..:..|.|.:.:|.:.|
plant    73 RIVLN----IRDSKRTVVGAAASALYLIKKREVVAIIGPGNSMQAPFLINLGNQSQVPIISF--- 130

  Fly   118 PQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLH 182
                                     :|.|.:|.|.            ||.:.||..|..: .|:|
plant   131 -------------------------SASSPVLDSL------------RSPYFIRATHDDS-SQVH 157

  Fly   183 KAGIKMQEFERGDDYRILWKRI------NNAREKFV--LLDCPSDILV--------------DVI 225
            .....::.|.        |:.:      |...|..:  |:|...:|.|              |::
plant   158 AISAIIESFR--------WREVVPIYADNEFGEGILPYLVDAFQEINVRIRYRSAISVHSTDDLV 214

  Fly   226 NASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVA-VAAVRIRTY---VPPPVHDEIDVF-D 285
            ...: |.:......:|:.::...|.      ||.|::| ...:..:.|   |...:.|::.|. :
plant   215 KKEL-YKLMTMPTRVFIVHMLPDLG------SRLFSIAKEIGMMTKGYVWIVTNGIADQMSVMGE 272

  Fly   286 NSVDTRFSSLGSQLVYD-SIVLFYNALLEISQRPGF---YIPNFSC------------------- 327
            :|::.....||.:..:. |..|.|   ||...|..|   .:.||.|
plant   273 SSLENMHGVLGVKTYFSRSKELMY---LETRWRKRFGGEELNNFECWGYDTATALAMSIEEISSN 334

  Fly   328 ----------------------GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDF 370
                                  ...|...||:|::.:..::.|.|...|:.:      :|:.|..
plant   335 VNMSFSQTKRNTSRDDTGTDLDDLSFALSGPKLLQALATVSFKGVAGRFQLK------NGKLEAT 393

  Fly   371 NLEVYN--PIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKP 433
            ..::.|  ...:|....|..:..||  :.||.|.| .:|.....::    .:||.:.     |..
plant   394 TFKIVNIEESGERTVGFWKSKVGLV--KSLRVNQT-GIKISHSSHR----LRPIIWP-----GDT 446

  Fly   434 YFSWREEPEGVHYEGNER----------------------------FEGYAVDLIYMLAQECKFD 470
            .|    .|:|..:..|.:                            ..|:.:|:.....::..:.
plant   447 IF----VPKGWEFPTNAKKLRIAVPKKDGFNNFVEVTKDANTNAPTITGFCIDVFDTAMRQMPYA 507

  Fly   471 FNFEPV----RDNK-YGSYDANT-----DEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVP 525
            ..:|.:    .|.| .||||...     .|:||            .:.|.||...|.:.|||.:|
plant   508 VPYEYIPFETPDGKPRGSYDEMVYHVFLGEFDG------------AVGDTTILANRSTYVDFALP 560

  Fly   526 FMQLGISILSYKEPPPKADIYAFLNPYNAEVWL-----FVMIAMMITAFALIFTGRIDQYEWDQP 585
            :.:.||.::...:...:...:.||.|...|:|.     |:.|.:|:..|         :|:
plant   561 YSETGIVVVVPVKDEREKGKWVFLKPLTRELWFLTAASFLYIGIMVWIF---------EYQ---- 612

  Fly   586 VENVNREMERQNIWH-LSNALWLVLGSMLNQGCDLLP-RGLPMRLLTAFWWIFALLISQTYIAKL 648
               .:.:..:|:|.: :||..:....::.  ...:.| ..:..|:|...|....|:::|:|.|.|
plant   613 ---ASGDFRKQSIINKISNVFYFSFSTLF--FAHMRPSESIFTRVLVVVWCFVLLILTQSYTATL 672

  Fly   649 AAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKP------ 707
            .:.:|..::...:..:.||           |....::.:...:.|..|:   |.:.:|.
plant   673 TSMLTVQELRPTVRHMDDL-----------RNSGVNIGYQTGSFTFERL---KQMGYKESRLKTY 723

  Fly   708 -------DAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNC-ELTQIGESFGEKHYGIAVP 764
                   :.|.|.:..|        |..|...|...::.::.:.| :.|.|..:|....:|.|.|
plant   724 DTPQEMHELFLKKSSNG--------GIDAAFDEVAYVKLFMAKYCSKYTIIEPTFKADGFGFAFP 780

  Fly   765 LNADFRSNLSVGILRLSERGELFK-LRNKWFNSNESTCDSNVPTIDDGQFDMD--SVGGLFVVLI 826
            |.:....:||..||.::| ||..| :.|||....:...||   |..|....:|  |...||.::.
plant   781 LGSPLVPDLSRQILNITE-GETMKAIENKWLLGEKHCLDS---TTSDSPIRLDHHSFEALFTIVF 841

  Fly   827 V 827
            |
plant   842 V 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	80/456 (18%)
		ANF_receptor	41..378	CDD:279440	73/426 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	84/432 (19%)
		Lig_chan	555..822	CDD:278489	59/290 (20%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	82/460 (18%)
		GluR_Plant	460..810	CDD:270404	77/402 (19%)
		Lig_chan	590..842	CDD:365843	61/295 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920