DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR1.1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	937	Identity:	188/937 - (20%)
Similarity:	346/937 - (36%)	Gaps:	225/937 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHGLQFLVLLALAIASGANEDTLV--IKIGAIFFDTEMK---LADAFSAALEEVNAINPALKLDA 60
            :..:..|.||...:.:..::|.:.  :::|.:...:.::   |..:|:.||.:...||     :.
plant     4 LFSISILALLFSGVVAAPSDDDVFEEVRVGLVVDLSSIQGKILETSFNLALSDFYGIN-----NG 63

  Fly    61 IKRYVTV------DDSIVLQDISCDLIGSGVA-AIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHP 118
            .:..|:|      .|.|:....:.||:.:..| ||.|..|...:.::..:.....:|.:. .:.|
plant    64 YRTRVSVLVRDSQGDPIIALAAATDLLKNAKAEAIVGAQSLQEAKLLATISEKAKVPVIS-TFLP 127

  Fly   119 QQSNRERMNH--QLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQL 181
            ...:.::.::  |.|.:.......:::...|      |..||..:.||.:........||. :..
plant   128 NTLSLKKYDNFIQWTHDTTSEAKGITSLIQD------FSCKSVVVIYEDADDWSESLQILV-ENF 185

  Fly   182 HKAGI---KMQEF---ERGDDYRILWKRINNAREKFVLLDCPSDILVD----------VINASIG 230
            ...||   :...|   ..|:::.:...|........|.:...|:|||.          ::..:..
plant   186 QDKGIYIARSASFAVSSSGENHMMNQLRKLKVSRASVFVVHMSEILVSRLFQCVEKLGLMEEAFA 250

  Fly   231 YNMTG-SFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVF--------DN 286
            :.:|. :.|:|....:...:.|:.||              ::|:  ||.:|:..|        .:
plant   251 WILTARTMNYLEHFAITRSMQGVIGF--------------KSYI--PVSEEVKNFTSRLRKRMGD 299

  Fly   287 SVDTRFSSLGSQL-VYDSIVLFYNALLEISQRPGFYIPNFS-CGRGFWQPGPRLVEQMKQITPKM 349
            ..:|..||:...| .:|...:..||           :..|| .|:         ||....::..:
plant   300 DTETEHSSVIIGLRAHDIACILANA-----------VEKFSVSGK---------VEASSNVSADL 344

  Fly   350 VKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLREN-----STQALKQK 409
            :.....::...::.|.|..|      |..|       ::.|::|:..:.::.     |..:..|:
plant   345 LDTIRHSRFKGLSGDIQISD------NKFI-------SETFEIVNIGREKQRRIGLWSGGSFSQR 396

  Fly   410 RLQNKEDFSQKPIRYTVATRVGK--------------PYF-SWREEPEGVHYEGNERFEGYAVDL 459
            |.......|:|..|:.|....|:              |:. |.|.:||    .|.....|:.|::
plant   397 RQIVWPGRSRKIPRHRVLAEKGEKKVLRVLVTAGNKVPHLVSVRPDPE----TGVNTVSGFCVEV 457

  Fly   460 IYMLAQECKFDFNFE----PVRDNKYG-SYDANT--DEWDGIIRQLIDNNAQIGICDLTITQARR 517
            .    :.|...||:|    |.|.|... :|..:|  |::|          |.:|  |:|||..|.
plant   458 F----KTCIAPFNYELEFIPYRGNNDNLAYLLSTQRDKYD----------AAVG--DITITSNRS 506

  Fly   518 SVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW 582
            ..||||:|:..:||.||:.|:  ....::.|.:|:...:||......::|...:....|
plant   507 LYVDFTLPYTDIGIGILTVKK--KSQGMWTFFDPFEKSLWLASGAFFVLTGIVVWLVER------ 563

  Fly   583 DQPVENVNREMERQNIW--HLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYI 645
                 :||.|.  |..|  .||..||....:::....:.|.: :..|.|...|....|:::.:|.
plant   564 -----SVNPEF--QGSWGQQLSMMLWFGFSTIVFAHREKLQK-MSSRFLVIVWVFVVLILTSSYS 620

  Fly   646 AKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAF 710
            |.|    ||:|....:...|.:|          .||:|:...::....:...|:.::|.   |..
plant   621 ANL----TSTKTISRMQLNHQMV----------FGGSTTSMTAKLGSINAVEAYAQLLR---DGT 668

  Fly   711 TKNNEEGVDRVKLSKGTYA--FLM--ETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRS 771
            ..:....:..:.:..|.|.  |:|  ..||                   ...:|......:|...
plant   669 LNHVINEIPYLSILIGNYPNDFVMTDRVTN-------------------TNGFGFMFQKGSDLVP 714

  Fly   772 NLSVGILRLSERGELFKLRNKWFNSNES-TCDSN----VPTIDDGQ----FDMDSVGGLFVVLIV 827
            .:|..|.:|...|.|..:..|||...:| ...||    ..|.||.:    |....:.|||:  |.
plant   715 KVSREIAKLRSLGMLKDMEKKWFQKLDSLNVHSNTEEVASTNDDDEASKRFTFRELRGLFI--IA 777

  Fly   828 GVVVGLVIGVAEFLWH----VQRISVK 850
            |....||:  |..|:|    |.|:..|
plant   778 GAAHVLVL--ALHLFHTRQEVSRLCTK 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	69/405 (17%)
		ANF_receptor	41..378	CDD:279440	65/372 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	88/400 (22%)
		Lig_chan	555..822	CDD:278489	56/281 (20%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	72/427 (17%)
		ANF_receptor	45..377	CDD:279440	69/393 (18%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	84/387 (22%)
		Lig_chan	542..781	CDD:278489	60/290 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.920