DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR2.7

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	927	Identity:	187/927 - (20%)
Similarity:	344/927 - (37%)	Gaps:	213/927 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIK---RYVT---------VDD 69
            |.|: |..||:|.:     :.|..:||...  :.:||.:|. |..|   .|.|         ::|
plant    32 GQNQ-TTEIKVGVV-----LDLHTSFSKLC--LTSINISLS-DFYKYHSDYTTRLAIHIRDSMED 87

  Fly    70 SIVLQDISCDLI-GSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVN 133
            .:.....:.||| ...|:||.||.:...::.:..|.:.:.:|.:.|.                 .
plant    88 VVQASSAALDLIKNEQVSAIIGPRTSMQAEFMIRLADKSQVPTITFS-----------------A 135

  Fly   134 VAPM------ELFLSAAFSD-----ILAS--KTFDWKSFTIAY---ERSSHLIRLQHILAWKQLH 182
            ..|:      ..|:.|...|     .:|:  |:|.|::....|   |....::.|        |.
plant   136 TCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFGWRNVVAIYVDNEFGEGILPL--------LT 192

  Fly   183 KAGIKMQEF--------ERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNM------ 233
            .|...:|.|        :..:|.:||       :|.:.|:...:.:.|..:..::|:..
plant   193 DALQDVQAFVVNRCLIPQEANDDQIL-------KELYKLMTMQTRVFVVHMPPTLGFRFFQKARE 250

  Fly   234 -------------TGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFD 285
                         .|..|.|......:.|..:.|           .:.:|:::|.  ..::..|.
plant   251 IGMMEEGYVWLLTDGVMNLLKSNERGSSLENMQG-----------VLGVRSHIPK--SKKLKNFR 302

  Fly   286 NSVDTRFSSLGSQ--------LVYDSIVLFYNALLEISQRPGFYIPNFSCGR--------GFWQP 334
            ...:..|...|:.        ..||||.....|:.:.:.:...|....:.|.        |..:.
plant   303 LRWEKMFPKKGNDEEMNIFALRAYDSITALAMAVEKTNIKSLRYDHPIASGNNKTNLGTLGVSRY 367

  Fly   335 GPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPI--IDRVTHIWNKEFQLVDFEK 397
            ||.|::.:..:....:...|:.    ||  ||.|....:|.|.|  .:|:..:|.....:|:.:.
plant   368 GPSLLKALSNVRFNGLAGEFEL----IN--GQLESSVFDVINIIGSEERIIGLWRPSNGIVNAKS 426

  Fly   398 LRENSTQALKQKRL-------QNKEDFSQKPIRYTVAT-----RVGKP-------YFSWREEPEG 443
              :|:|..|.: ||       ::|:    .|..:.:.|     |||.|       :...:.:|
plant   427 --KNTTSVLGE-RLGPVIWPGKSKD----VPKGWQIPTNGKMLRVGIPVKKGFLEFVDAKIDP-- 482

  Fly   444 VHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGIC 508
              ........||.:::...:.:  |..::..|    ||.::.:..:.:|.::.|:........:.
plant   483 --ISNAMTPTGYCIEIFEAVLK--KLPYSVIP----KYIAFLSPDENYDEMVYQVYTGAYDAVVG 539

  Fly   509 DLTITQARRSVVDFTVPFMQLGISILSYKEPPPK--ADIYAFLNPYNAEVWLFVMIAMMITAFAL 571
            |:||...|...||||:|:.:.|:|::    .|.|  .:.:.||.|::.::|       :.||...
plant   540 DVTIVANRSLYVDFTLPYTESGVSMM----VPLKDNKNTWVFLRPWSLDLW-------VTTACFF 593

  Fly   572 IFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIF 636
            :|.|.|   .|... ..||.:........:..:.|....:|.....:.:...| .|.:...|...
plant   594 VFIGFI---VWILE-HRVNTDFRGPPHHQIGTSFWFAFSTMNFAHREKVVSNL-ARFVVLVWCFV 653

  Fly   637 ALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNK---VQFGT-IRGGATSVYFSESNDTDNRM 697
            .|::.|:|.|.|.:|.|...:...:.:..||:..||   .|.|| :|....|..|.||
plant   654 VLVLIQSYTANLTSFFTVKLLQPTVTNWKDLIKFNKNIGYQRGTFVRELLKSQGFDES------- 711

  Fly   698 AWNKMLSFKPDAFTKNNEEGVDRVKLSKGTY-AFLMETTNLQYYVQRN-CELTQIGESFGEKHYG 760
                  ..||.......:|     ..|.||. |...|...::..:.:| .:.|.:..||....:|
plant   712 ------QLKPFGSAVECDE-----LFSNGTITASFDEVAYIKVILSQNSSKYTMVEPSFKTAGFG 765

  Fly   761 IAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVL 825
            ...|..:....::|..||.:::..|:..:.||||....:..|.|. ::......:.|..|||::.
plant   766 FVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFKKPNNCPDLNT-SLSSNHLSLSSFWGLFLIA 829

  Fly   826 IVGVVVGLVIGVAEFLW 842
            .:...:.|:|.||.||:
plant   830 GIASFLALLIFVANFLY 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	78/440 (18%)
		ANF_receptor	41..378	CDD:279440	72/408 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	84/392 (21%)
		Lig_chan	555..822	CDD:278489	59/272 (22%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	78/439 (18%)
		ANF_receptor	54..405	CDD:279440	70/404 (17%)
		GluR_Plant	460..799	CDD:270404	82/382 (21%)
		Lig_chan	584..832	CDD:278489	61/278 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.920