DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR2.8

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	1007	Identity:	198/1007 - (19%)
Similarity:	345/1007 - (34%)	Gaps:	344/1007 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAIASGANEDTL-VIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIK---RY 64
            |.:.|.|.|.:..|..::.: .||:|.:     :.|...||...  :.:||.||. |..|   .|
plant    12 LSYFVCLFLLLEVGLGQNQISEIKVGVV-----LDLNTTFSKIC--LTSINLALS-DFYKDHPNY 68

  Fly    65 VT---------VDDSIVLQDISCDLI-GSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFD---- 115
            .|         :.|::.....:.||| ...|:||.||.....:..:..|.|.|.:|.:.|.
plant    69 RTRLALHVRDSMKDTVQASAAALDLIQNEQVSAIIGPIDSMQAKFMIKLANKTQVPTISFSATSP 133

  Fly   116 --------------------------------WH------------------------------- 117
                                            |.
plant   134 LLTSIKSDYFVRGTIDDSYQVKAIAAIFESFGWRSVVAIYVDNELGEGIMPYLFDALQDVQVDRS 198

  Fly   118 --PQQSNRER--------MNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRL 172
              |.::|.::        |..|..|.|..|        :..|||:.|         |:::.:..:
plant   199 VIPSEANDDQILKELYKLMTRQTRVFVVHM--------ASRLASRIF---------EKATEIGMM 246

  Fly   173 QHILAWKQLHKAGIKMQEFERG----------------------DDYRILWKRINNAREKFVLLD 215
            :....|...:.....|:....|                      :|:|:.||| |..:|...|.|
plant   247 EEGYVWLMTNGMTHMMRHIHHGRSLNTIDGVLGVRSHVPKSKGLEDFRLRWKR-NFKKENPWLRD 310

  Fly   216 CPS-------------DILVDVIN-ASIGY-NMTGSFNHLFLTNLDT-HLSGIDGFYSRDFTVAV 264
            ..|             .:.|:..| :|..| |.:||.|:  :|:|.| |:|.    |......|:
plant   311 DLSIFGLWAYDSTTALAMAVEKTNISSFPYNNASGSSNN--MTDLGTLHVSR----YGPSLLEAL 369

  Fly   265 AAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGR 329
            :.:|.                |.:..||:.:..||                :.|.|.|.||....
plant   370 SEIRF----------------NGLAGRFNLIDRQL----------------ESPKFEIINFVGNE 402

  Fly   330 ----GFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEF 390
                |||.|...||                    .:|:: :...|..|.:.|:      ||..:.
plant   403 ERIVGFWTPSNGLV--------------------NVNSN-KTTSFTGERFGPL------IWPGKS 440

  Fly   391 QLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWRE----------EPEGVH 445
            .:|  .|..|..|...|.|                |...|.|.:|::.|          .|
plant   441 TIV--PKGWEIPTNGKKIK----------------VGVPVKKGFFNFVEVITDPITNITTP---- 483

  Fly   446 YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDN---NAQIGI 507
                   :|||:|:.....:  |..::..|    :|..:::..|::|.::.: :||   :|.:|
plant   484 -------KGYAIDIFEAALK--KLPYSVIP----QYYRFESPDDDYDDLVYK-VDNGTLDAVVG- 533

  Fly   508 CDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL-----FVMIAMMIT 567
             |:|||..|....|||:|:.:.|:|::.........:.:.||.|:..::|:     ||:|..::.
plant   534 -DVTITAYRSLYADFTLPYTESGVSMMVPVRDNENKNTWVFLKPWGLDLWVTTACFFVLIGFVVW 597

  Fly   568 AFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAF 632
            .|.                ..||.:........:..:.|....:|:....:.:...| .|.:...
plant   598 LFE----------------HRVNTDFRGPPHHQIGTSFWFSFSTMVFAHREKVVSNL-ARFVVVV 645

  Fly   633 WWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRM 697
            |....|:::|:|.|.|.:|:|..:......::.||          |:.|
plant   646 WCFVVLVLTQSYTANLTSFLTVQRFQPAAINVKDL----------IKNG---------------- 684

  Fly   698 AWNKMLSFKPDAFTKN--NEEG--VDRVK-----------LSKGTY-AFLMETTNLQYYVQRNCE 746
               ..:.::..||.|:  .:||  |.::|           ||.|:. |...|...|:..:.:.|.
plant   685 ---DYVGYQHGAFVKDFLIKEGFNVSKLKPFGSSEECHALLSNGSISAAFDEVAYLRAILSQYCS 746

  Fly   747 LTQIGE-SFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD 810
            ...|.| :|....:|.|.|.|:....::|..||.:::..|:..:.|||| ..::.|......:..
plant   747 KYAIVEPTFKTAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQHIENKWF-MKQNDCPDPKTALSS 810

  Fly   811 GQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLW 842
            .:..:.|..|||::..:...:.|:|.|..||:
plant   811 NRLSLRSFWGLFLIAGIASFLALLIFVFLFLY 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	91/498 (18%)
		ANF_receptor	41..378	CDD:279440	85/468 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	84/407 (21%)
		Lig_chan	555..822	CDD:278489	55/288 (19%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	85/467 (18%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	85/422 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.920