DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GLR2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	1036	Identity:	222/1036 - (21%)
Similarity:	393/1036 - (37%)	Gaps:	251/1036 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLL--ALAIASGANED-TLVIKIGAIFFDTEM--KLAD-AFSAALEEVNAINPALKLDAIK 62
            |.|:::|  .|.::.||:.. ..|||:||||....|  :.|: ||.||.|:||: :|:. |...|
plant    10 LSFIIVLGGGLLLSEGASSSRPPVIKVGAIFGLNTMYGETANIAFKAAEEDVNS-DPSF-LGGSK 72

  Fly    63 RYVTVDD-------SIV--LQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFD-WH 117
            ..:.::|       ||:  ||.:..|     |.||.||.:...:.::..|.|...:|.|.|. ..
plant    73 LRILMNDAKRSGFLSIMGALQFMETD-----VVAIIGPQTSIMAHVLSHLANELTVPMLSFTALD 132

  Fly   118 PQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLH 182
            |..|   .:.....|..||.:|||..|.::::.  .:.|......|....:             .
plant   133 PTLS---PLQFPFFVQTAPSDLFLMRAIAEMIT--YYGWSDVVALYNDDDN-------------S 179

  Fly   183 KAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDIL----VDVINASIGYNMTGSFNHLFLT 243
            :.|:.    ..||:   |.:|......|.||   |.|::    |::|...|  .:.|..:.:.:.
plant   180 RNGVT----ALGDE---LEERRCKISYKAVL---PLDVVITSPVEIIEELI--KIRGMESRVIVV 232

  Fly   244 N----------------------------------------LDTHL-SGI--------DGFYSRD 259
            |                                        |||.| :|:        |....||
plant   233 NTFPNTGKMIFKEAERLGMMEKGYVWIATTWLSSVLDSNLPLDTKLVNGVLTLRLHTPDSRKKRD 297

  Fly   260 F------------TVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALL 312
            |            |:.:....:..|      |.:.:...:|.|...:.|:        |.::...
plant   298 FAARWKNKLSNNKTIGLNVYGLYAY------DTVWIIARAVKTLLEAGGN--------LSFSNDA 348

  Fly   313 EISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNP 377
            ::....|..: |.|....|.| |.:|::.:..     .|....|..:|.:.|......:.::.|.
plant   349 KLGSLKGEAL-NLSALSRFDQ-GSQLLDYIVH-----TKMSGLTGPVQFHPDRSMLQPSYDIINL 406

  Fly   378 IIDRVTHI--WN--KEFQLVDFEKL------RENSTQALKQ--------------------KRLQ 412
            :.|||..|  |:  ....:|..|..      |.:|.|.|..                    :||
plant   407 VDDRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRGWIFRNNGRRL- 470

  Fly   413 NKEDFSQKPIRYTVATRVGKP-YFSWREEPEGVHYEGNERFEGYAVDL----IYMLAQECKFDFN 472
                            |:|.| ..|:::....|:...| :.:||.:|:    :.:|:.....:|.
plant   471 ----------------RIGVPDRASFKDFVSRVNGSSN-KVQGYCIDVFEAAVKLLSYPVPHEFI 518

  Fly   473 FEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILS-- 535
            |  ..|   |..:.|.:|....:...:|.:|.:|  |:.|...|..:||||.|:::.|:.:::
plant   519 F--FGD---GLTNPNYNELVNKVTTGVDFDAVVG--DIAIVTKRTRIVDFTQPYIESGLVVVAPV 576

  Fly   536 --YKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFAL-IFTGRIDQYEWDQPVENVNREMERQN 597
              ..|.|     :|||.|:...:|.......:|...|: |...||:. |:..|       ..||.
plant   577 TRLNENP-----WAFLRPFTLPMWAVTASFFVIVGAAIWILEHRIND-EFRGP-------PRRQI 628

  Fly   598 IWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIG 662
            |    ..||....:|.....:.....|. |::...|....|:|:.:|.|.|.:.:|..::...|.
plant   629 I----TILWFTFSTMFFSHRETTVSTLG-RMVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIK 688

  Fly   663 SLHDLVDQNKVQFGTIRGGATSVYFSESNDTDN-RMAWNKMLSF-KPDAFTKNNEEGVDRVKLSK 725
            .:..|:.      .|.|.|.....|:|:..||. .:|.::::.. .|:.:..         .|..
plant   689 GVDTLIS------STGRIGFQVGSFAENYMTDELNIASSRLVPLASPEEYAN---------ALQN 738

  Fly   726 GTYAFLM-ETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKL 789
            ||.|.:: |...:..::...|:....|:.|....:|.|.|.::....::|..||.|||.|||.|:
plant   739 GTVAAIVDERPYIDLFLSDYCKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQKI 803

  Fly   790 RNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIG----VAEFLWHVQRISVK 850
            .::|.:.:..:......:.|..|.::.|..|:|:|:.:..:|.|.|.    :.:|......:.|:
plant   804 HDRWLSKSNCSSPHGSQSGDSEQLNVHSFWGMFLVVGIACLVALFIHFFKIIRDFCKDTPEVVVE 868

  Fly   851 EKIP-PMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKKTRR 910
            |.|| |..:...:....:.| :..|...|.|:.:...:..:|     .:|:|...:..:||
plant   869 EAIPSPKSSRLTKLQTFLAF-VDEKEEETKRRLKRKRNNDHS-----MNANSIISRTASRR 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	92/448 (21%)
		ANF_receptor	41..378	CDD:279440	80/411 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	90/385 (23%)
		Lig_chan	555..822	CDD:278489	60/270 (22%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	92/446 (21%)
		GluR_Plant	468..808	CDD:270404	91/397 (23%)
		Lig_chan	594..843	CDD:306551	62/276 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.870