Protein Alignment GluRIIB and grik5

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001315085.1
• Gene: grik5 / 798791
• ZFINID: ZDB-GENE-070821-6
• Length: 1067
• Species: Danio rerio
• Alignment Length: 956
• Identity: 268/956 - (28%)
• Similarity: 458/956 - (47%)
• Gaps: 128/956 - (13%)

  Fly     5 QFLVLLALAIASGANEDTLV---IKIGAIFFDTEM-----KLADAFSAALEEVNAI--NPA---L 56
            :||::..:.:...:...|.|   :::.||..|:.:     :|  |.:.|.|.:|::  |||   :
Zfish    14 RFLLVTVVTMPPSSLSQTPVLSSVRMAAILDDSSVCGRGERL--ALALARENINSVMENPARARV 76

  Fly    57 KLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGP-SSKTNSDIVEVLCNMTGIPHLQFDWHPQQ 120
            ::|..:  :..|......|..|.::..||.::.|| ||..:..||..:|....|||::..  |::
Zfish    77 EVDIFE--LQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHVKIG--PEE 137

  Fly   121 SNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAG 185
            :.|.......:|.:.|....||.|...||  ::|.:.|.::...::..|:||:.::....:.:..
Zfish   138 TPRLPYLRFASVTLYPSNEDLSLAIGSIL--RSFSYPSASLVCAKAECLLRLEELIRRFLISRET 200

  Fly   186 IKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGY---------NMTGSFNHLF 241
            :.::..:...|...|.|.|.:.:...:::|.         ||||.|         .||.:|....
Zfish   201 LSIRMLDDNLDPTPLLKEIRDDKIATIIIDA---------NASISYLILKKASELGMTSAFYKYI 256

  Fly   242 LTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-----------SSL 295
            ||.:|..|..:|........:...::...|:   |.:.|   |..|::..:           .:|
Zfish   257 LTTMDFPLLWLDDIVDEQSNIVGFSMFNTTH---PFYLE---FIRSLNLSWREGCDINPYPGPAL 315

  Fly   296 GSQLVYDSIVLFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRL 359
            .|.|::|::.:..:|:.|:::.....:...|| ....||.|..|:..:     :||:....|.|:
Zfish   316 SSALLFDAVHVVVSAVQELNRSQEIGVKPLSCTSPQIWQHGTSLMNYL-----RMVEYDGLTGRV 375

  Fly   360 QINADGQREDFNLEVYNPIIDRVTH----IW-NKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQ 419
            :.|:.|||.::.|.:...  .|..|    || :....|::...|..|.::.|..|.|
Zfish   376 EFNSKGQRTNYTLHILEK--HRGGHKEIGIWYSNNTLLMNSTSLDINVSETLANKSL-------- 430

  Fly   420 KPIRYTVATRVGKPY----FSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNK 480
                 .:.|.:..||    .:::|      :||||::||:.||::..|:...||.:..:.|.|..
Zfish   431 -----IITTILENPYVMRKINYQE------FEGNEQYEGFCVDMLRELSDILKFTYRIKLVDDGL 484

  Fly   481 YGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADI 545
            ||:.:.| ..|.|::.:||:..|.:.:...|||..|..|:||:.|||.||||||.......|...
Zfish   485 YGAPEPN-GSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGY 548

  Fly   546 YAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREME-RQNIWHLSNALWLVL 609
            ::||:|::..||||:::|.:..:..|..:.|:..|||..|...:....: .:|.:.|.|:||..:
Zfish   549 FSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRERRDLLENQYTLGNSLWFPV 613

  Fly   610 GSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQ 674
            |..:.||.:::||.|..|.::..||.|.|:|..:|.|.||||:|..::...|.|..||.||..:|
Zfish   614 GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQ 678

  Fly   675 FGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQY 739
            :|||.||:|..:|..|.....:..||.|.|.:|..|.|:.|||:.||..||  ||||:|:|..:|
Zfish   679 YGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVNSK--YAFLLESTMNEY 741

  Fly   740 YVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSN 804
            :...||.|||||.....|.|||.:||.:.||..||:.:|:|.|...|..|:.:|:...:  |
Zfish   742 HRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEGGK--C--- 801

  Fly   805 VPTIDDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFV 866
             |..:|.:   ..|:::||:|||||.|:::.:.:.|.||:|..:|.:..:::
Zfish   802 -PKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTRRSAETDEV------------- 852

  Fly   867 IRFWLTRKPLHTYRQ--SRDSTSTGYSSLEQITSASSAKKKKKTRR 910
                   :||...||  |..:.|.....|.:..:|.|.||..:.||
Zfish   853 -------RPLSCDRQYHSHTTVSVCQEMLTEFRNAVSCKKSSRLRR 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	89/403 (22%)
		ANF_receptor	41..378	CDD:279440	81/363 (22%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/377 (37%)
		Lig_chan	555..822	CDD:278489	100/270 (37%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	89/403 (22%)
		ANF_receptor	55..392	CDD:279440	82/364 (23%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	18/74 (24%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	141/391 (36%)
		Lig_chan	558..828	CDD:278489	105/277 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850