DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and gria1a

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	878	Identity:	241/878 - (27%)
Similarity:	395/878 - (44%)	Gaps:	113/878 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPAL--KLDAIKRYVTVDDSIVLQDISCDLIGSGVAA 87
            |.||.: |.||....:.|..||.....| |.|  ::|.:|    :.:|..:....|.....||.|
Zfish    25 INIGGL-FPTESHEYEVFRFALSHHQDI-PKLVPQVDMVK----LGNSFSMTYAFCSQFSKGVYA 83

  Fly    88 IFGPSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDIL 149
            |.|...:..   |.:|.:..|..|:.|   .:..:.||      |..:.:.| ||      .|.|
Zfish    84 IIGVYDRKT---VNMLMSFCGALHVCFVTPSFPMENSN------QFVIQLRP-EL------QDAL 132

  Fly   150 AS--KTFDWKSFTIAYERSSHLIRLQHILAWKQLHK---AGIKMQEFERGDDYRILWKRINNARE 209
            ..  :.:.|..|...|...|.|..||.:|.....|.   ..:.::........:: ::.::..:|
Zfish   133 VGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFLKV-FQDLDKKKE 196

  Fly   210 KFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFT------VAVAAVR 268
            ..:::||..:.|..::...|.........|..|.||        ||...|.|      ..|...:
Zfish   197 GQIIIDCELERLTSILKKIIELGKNVKSYHYILANL--------GFLDIDLTEFKKGEANVTGFQ 253

  Fly   269 IRTYVPPPVHD------EIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--P 318
            :..|..|.|..      |.|..|..|..|.......|.||.:.:...|.       ::||:|  .
Zfish   254 LVNYADPNVSRTVQQWMEFDNKDAKVPKRRLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRGNA 318

  Fly   319 GFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEV--YNPIIDR 381
            |..:.|....   |..|..:...::|:..:.:     |..:|.|..|:|.::::.|  ..|...:
Zfish   319 GECLANPPAP---WGQGIDIQRALQQVRIEGL-----TGHIQFNEKGRRTNYSISVMELRPTGPK 375

  Fly   382 VTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHY 446
            ....||::.:.|........|.:..   .|||:        .|.|.|.:..||...::..|  |:
Zfish   376 KVGYWNEDEKFVSTAAYMPGSNETY---GLQNR--------TYIVTTILESPYVMLKKNHE--HF 427

  Fly   447 EGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLT 511
            .||:::|||.|:|...:|:...:.:..:.|.|.|||:.||.|..|:|::.:|:...|.:.:..||
Zfish   428 TGNDKYEGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLT 492

  Fly   512 ITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGR 576
            ||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|....|
Zfish   493 ITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 557

  Fly   577 IDQYEW-------------DQP----------VENVNREMERQ-NIWHLSNALWLVLGSMLNQGC 617
            ...|||             :||          .:|.|::.:.| |.:.:.|:||..||:.:.|||
Zfish   558 FSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGC 622

  Fly   618 DLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGA 682
            |:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:
Zfish   623 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGS 687

  Fly   683 TSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CE 746
            |..:|..|........|:.|.|..|..|.|..:|||.||:.|||.||:|:|:|..:|..||. |:
Zfish   688 TKEFFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCD 752

  Fly   747 LTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD- 810
            ..::|.:...|.||||.|..:..|:.:::.:|:|:|:|.|.||:|||: .::..|.|......|
Zfish   753 TMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKDK 816

  Fly   811 -GQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLW 842
             ....:.:|.|:|.:||.|:.:.:::.:.||.:
Zfish   817 TSALSLSNVAGVFYILIGGLGLAMLVALVEFCY 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	85/399 (21%)
		ANF_receptor	41..378	CDD:279440	77/369 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/397 (35%)
		Lig_chan	555..822	CDD:278489	96/293 (33%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	85/399 (21%)
		ANF_receptor	36..369	CDD:279440	77/370 (21%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	140/412 (34%)
		Lig_chan	536..836	CDD:278489	99/300 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591010
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840