Protein Alignment GluRIIB and gria1a

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_991161.1
• Gene: gria1a / 798689
• ZFINID: ZDB-GENE-020125-1
• Length: 914
• Species: Danio rerio
• Alignment Length: 878
• Identity: 241/878 - (27%)
• Similarity: 395/878 - (44%)
• Gaps: 113/878 - (12%)

  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPAL--KLDAIKRYVTVDDSIVLQDISCDLIGSGVAA 87
            |.||.: |.||....:.|..||.....| |.|  ::|.:|    :.:|..:....|.....||.|
Zfish    25 INIGGL-FPTESHEYEVFRFALSHHQDI-PKLVPQVDMVK----LGNSFSMTYAFCSQFSKGVYA 83

  Fly    88 IFGPSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDIL 149
            |.|...:..   |.:|.:..|..|:.|   .:..:.||      |..:.:.| ||      .|.|
Zfish    84 IIGVYDRKT---VNMLMSFCGALHVCFVTPSFPMENSN------QFVIQLRP-EL------QDAL 132

  Fly   150 AS--KTFDWKSFTIAYERSSHLIRLQHILAWKQLHK---AGIKMQEFERGDDYRILWKRINNARE 209
            ..  :.:.|..|...|...|.|..||.:|.....|.   ..:.::........:: ::.::..:|
Zfish   133 VGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFLKV-FQDLDKKKE 196

  Fly   210 KFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFT------VAVAAVR 268
            ..:::||..:.|..::...|.........|..|.||        ||...|.|      ..|...:
Zfish   197 GQIIIDCELERLTSILKKIIELGKNVKSYHYILANL--------GFLDIDLTEFKKGEANVTGFQ 253

  Fly   269 IRTYVPPPVHD------EIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--P 318
            :..|..|.|..      |.|..|..|..|.......|.||.:.:...|.       ::||:|  .
Zfish   254 LVNYADPNVSRTVQQWMEFDNKDAKVPKRRLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRGNA 318

  Fly   319 GFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEV--YNPIIDR 381
            |..:.|....   |..|..:...::|:..:.:     |..:|.|..|:|.::::.|  ..|...:
Zfish   319 GECLANPPAP---WGQGIDIQRALQQVRIEGL-----TGHIQFNEKGRRTNYSISVMELRPTGPK 375

  Fly   382 VTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHY 446
            ....||::.:.|........|.:..   .|||:        .|.|.|.:..||...::..|  |:
Zfish   376 KVGYWNEDEKFVSTAAYMPGSNETY---GLQNR--------TYIVTTILESPYVMLKKNHE--HF 427

  Fly   447 EGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLT 511
            .||:::|||.|:|...:|:...:.:..:.|.|.|||:.||.|..|:|::.:|:...|.:.:..||
Zfish   428 TGNDKYEGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLT 492

  Fly   512 ITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGR 576
            ||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|....|
Zfish   493 ITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 557

  Fly   577 IDQYEW-------------DQP----------VENVNREMERQ-NIWHLSNALWLVLGSMLNQGC 617
            ...|||             :||          .:|.|::.:.| |.:.:.|:||..||:.:.|||
Zfish   558 FSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGC 622

  Fly   618 DLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGA 682
            |:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:
Zfish   623 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGS 687

  Fly   683 TSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CE 746
            |..:|..|........|:.|.|..|..|.|..:|||.||:.|||.||:|:|:|..:|..||. |:
Zfish   688 TKEFFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCD 752

  Fly   747 LTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD- 810
            ..::|.:...|.||||.|..:..|:.:::.:|:|:|:|.|.||:|||: .::..|.|......|
Zfish   753 TMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKDK 816

  Fly   811 -GQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLW 842
             ....:.:|.|:|.:||.|:.:.:::.:.||.:
Zfish   817 TSALSLSNVAGVFYILIGGLGLAMLVALVEFCY 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	83/393 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/397 (35%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_type1	26..390	CDD:471960	86/402 (21%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	140/412 (34%)
		Lig_chan	536..835	CDD:459656	99/299 (33%)