DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grik1a

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	903	Identity:	261/903 - (28%)
Similarity:	440/903 - (48%)	Gaps:	113/903 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIKIGAIFFDTEMKLAD----AFSAALEEVN-----AINPALKLDAIKRYVTVDDSIVLQDISCD 79
            ||:||.||...|.:...    ||..|:..:|     ..|..|..| |:| |.:.||.......||
Zfish    38 VIRIGGIFETRENEPVSMDELAFKFAVTSINRNRTLMPNTTLTYD-IQR-VNLFDSFEASRRVCD 100

  Fly    80 LIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQSNRERMNHQLTVNVAPMELFLSA 143
            .:..||||:||||..::...|:.:||...:||:|..| ||...|::    ...:|:.|....:|.
Zfish   101 QLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKD----NFYINLYPEYTSISR 161

  Fly   144 AFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEF-ERGDDYRILWKRINNA 207
            |..||:.  .:.||..|:.||.|:.|:|:|.::.....:...|::::. ..|.|.|.|.|.:...
Zfish   162 AILDIVI--FYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSRPLLKEMKKE 224

  Fly   208 REKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF-YSRDFTVAVAAVRI-- 269
            :|.:|:.||...:..:::...:...|...:.|.|.|.||.....::.: ||   .|.:.|.|:
Zfish   225 KEFYVIFDCSYQVAAELLKQLMSMGMMTEYYHFFFTTLDLFALDLEPYRYS---GVNMTAFRLLN 286

  Fly   270 ----------------RTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEI---S 315
                            |...||...              |.|.|.::..:..|.|:|:..:   |
Zfish   287 LDDSYVASVIQKWSMERQLAPPKPE--------------SGLMSGIMTTAAALMYDAVFMVAVAS 337

  Fly   316 QR-PGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN-ADGQREDFNLEVYNP 377
            || ....:.:..|.|.. |:.|||.:...|:     .:....|.|:.:| .||.|::|||::.:.
Zfish   338 QRATQMTVSSLQCHRHKPWRYGPRFMNLFKE-----AQWDGLTGRIVLNKTDGLRKEFNLDLISL 397

  Fly   378 IID-----------RVTHIWNK-----EFQLVDFEKLRENS--TQALKQKRLQNKEDFSQKPIRY 424
            ..|           |...:|.|     .:..::..::::|.  |.:|..:.|
Zfish   398 KEDGTAKRVADGASRPNKLWTKIGVWNSYTGLNLTEIKDNKNITDSLANRTL------------- 449

  Fly   425 TVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTD 489
            .|.|.:..||..:::..:.::  ||:|||||.:||:..|:....|.:..:.|.|.|||:.: :..
Zfish   450 IVTTILENPYVMYKKSDKVLY--GNDRFEGYCLDLLKELSNILGFTYEVKLVTDGKYGAQN-DKG 511

  Fly   490 EWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNA 554
            ||:|::|:|||:.|.:.:..||||..|..|:||:.|||.||||||..|.......:::||||...
Zfish   512 EWNGMVRELIDHIADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLTP 576

  Fly   555 EVWLFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSNALWLVLGSMLNQGCD 618
            ::|::|::|.:..:..|....|...|||..|.. |.:.|:...| :.|.|:||..:.:::.||.:
Zfish   577 DIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPSSEVVENN-FTLLNSLWFGVAALMRQGSE 640

  Fly   619 LLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGAT 683
            |:|:.|..|:|...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::::|.:|.|:|
Zfish   641 LMPKALSTRILGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGST 705

  Fly   684 SVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELT 748
            ..:|.:|..:.....|..|.|.|..|..||:::|:.||..:  .||.|||:|:::|..||||.||
Zfish   706 MTFFKKSKISTYEKMWAFMSSRKNTALVKNSKDGITRVLTT--DYALLMESTSIEYITQRNCNLT 768

  Fly   749 QIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ- 812
            |:|.....|.||:..|:.:.:|..:::.||:|.|.|:|..::.||:..|      ..|..|..:
Zfish   769 QVGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWRGN------GCPEEDSKEA 827

  Fly   813 --FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIR 868
              ..::::||:|:||..|:|:.:.:.:.||::...:.|..|:.....|:..:....:|
Zfish   828 SALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSHKNSDIEECVSFSAVMEDLGISLR 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	105/418 (25%)
		ANF_receptor	41..378	CDD:279440	96/368 (26%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	134/373 (36%)
		Lig_chan	555..822	CDD:278489	89/270 (33%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	107/423 (25%)
		ANF_receptor	57..398	CDD:279440	96/370 (26%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	135/387 (35%)
		Lig_chan	577..846	CDD:278489	92/277 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750