DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and grid1a

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	925	Identity:	212/925 - (22%)
Similarity:	396/925 - (42%)	Gaps:	137/925 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLALAI----ASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYV-T 66
            |::::|::    ...|..|: :|.|||||....::..:.|..|:.:::..:..|:.:.|...: .
Zfish     3 LLVISLSLWILQCRSARADS-IIHIGAIFEQNAIRDDEVFQLAISDLSLNDDILQSERITHSIKL 66

  Fly    67 VDDSIVLQDI--SCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHL----QFDWHPQ---QSN 122
            ::.:...|.:  :|:|:..|:.|:...:....::.::.|.:...||||    ..|..|:   |.|
Zfish    67 IEPNNPFQAVQEACELMNQGILALVSSTGCAAANALQSLTDAMHIPHLFIQRNGDGTPRAECQLN 131

  Fly   123 RERMNHQLTVNVAPMELFLSAAFSDILASKTFD--WKSFTIAYERSSHLIRLQHILAWKQLHKAG 185
            ......:.|:...|     ....:|::.:...:  |..|.:.|:....:..|:..|  .|..:.|
Zfish   132 PSPDGERYTLAARP-----PVRLNDVMITLVSELRWHKFIVFYDSEYDVRGLRGFL--DQASRMG 189

  Fly   186 --IKMQEFERG--DDYRILW-----KRINNARE---KFVLLDCPSDILVDVINASIGYNMTGSFN 238
              :.:|:.:|.  ..:..|:     :.:|..|:   :.:||..|....| .|:.::..|:....:
Zfish   190 LDVSLQQVDRNVTKVFSTLFSTMRMEELNRYRDTLRRAILLLSPRTAQV-FIHQAVETNLASKDS 253

  Fly   239 HLFLTN---LDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSL----- 295
            |....|   .||.:..:........||      ||...|......|....|  :.|.|||
Zfish   254 HWVYANEEVSDTEIMELVHSALGRMTV------IRQIFPLWRDTNIRCMRN--NHRISSLLCDPQ 310

  Fly   296 ---------GSQLVYDSIVLFYNALL-EISQRPGFYIPNFSCGRGF---WQPGPRLVEQMKQITP 347
                     .|..:|||:::..||.. ::..|....:.:.:|.|..   |..|..:::.:
Zfish   311 EGYLQSLEVSSLYLYDSVLMLANAFYRKLEDRKWHSMASLNCMRKSTKPWNGGWSMLDTI----- 370

  Fly   348 KMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLV----------DFEKLRE-N 401
                     |:.:|:......||.....|      :|:   :|:::          |.::|.. :
Zfish   371 ---------QKGRISGLTGLMDFRSNGAN------SHV---QFEILGTSYSETFGKDVKRLATWD 417

  Fly   402 STQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQE 466
            |.:.|.....:|:.|...:.|...|.|.:.:|:....|...|    ..:|::|:::|::..||:.
Zfish   418 SDRGLNGSLRENRADHGMQGITLKVVTLLEEPFVMVAENILG----QPKRYKGFSIDVLDALAKI 478

  Fly   467 CKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGI 531
            ..|.:....|.|.||||...| ..|:|:|.:||...|.:.|..:|||..|.:||||:..::...:
Zfish   479 LGFKYEMYQVADAKYGSPQTN-GSWNGMIGELIGKRADVAISAITITPERENVVDFSKRYLDYSV 542

  Fly   532 SILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQ 596
            .||..| ...:.:|::.|.|::..||..:..|:.:....:....|:      |.|.:.|.....|
Zfish   543 GILMTK-TEERLNIFSLLAPFDLAVWACIAAAIPVVGVMVFLLRRV------QSVRSQNPPGPHQ 600

  Fly   597 N---IWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIA 658
            .   .....:|:|:|.|:.:.||.:.....:.:|:....||:|.|::..:|.|.|||::|.|::.
Zfish   601 PASVTTSFQSAIWIVYGAFVQQGGESFMSSMALRIAMGSWWLFTLIVCSSYTANLAAYLTVSRMD 665

  Fly   659 GDIGSLHDLVDQNKVQFGTIRGGATSVYF----SESNDTDNRMA--W---NKMLSFKPDAFTKNN 714
            ..|.:..||..|:::.:||:|..|...||    :...:.|:..|  |   ||  :...|....:.
Zfish   666 NAIRTFQDLSKQSEINYGTVRESAVFEYFRVKGTNPLEQDSTFAELWRTINK--NQGQDNSVTSP 728

  Fly   715 EEGVDRVKLSKGTYAFLMETTNLQY--YVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGI 777
            .||:.:||  :..||||.:...|:|  ....:|.|...|.....|.||:|:...:.:|...|..|
Zfish   729 AEGIRKVK--RDPYAFLWDMAVLEYAALTDDDCTLVVTGNGMSSKGYGLALQHGSPYRDLFSQKI 791

  Fly   778 LRLSERGELFKLRNKWFNSNESTCDSN---VPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAE 839
            |.|.|:|:|..|:.||: ..:..||.:   .|..:.....:.|..|:|.:|..|:::..::...|
Zfish   792 LDLQEKGDLDILKQKWW-PRKGRCDLDKHAEPQTEGRALRLHSFAGVFCILAAGLLLACLVAALE 855

  Fly   840 FLWH---VQRISVKE 851
            ..|:   .||...||
Zfish   856 SWWNGPRCQRAQPKE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	77/411 (19%)
		ANF_receptor	41..378	CDD:279440	70/381 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	110/386 (28%)
		Lig_chan	555..822	CDD:278489	75/283 (27%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	81/437 (19%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	110/388 (28%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740