DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grid2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	215/923 - (23%)
Similarity:	391/923 - (42%)	Gaps:	165/923 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVT-VDDSIVLQDI--SCD 79
            |..|: :|.|||||.::..|..:.|..|:.::|.....|:.:.|...|| ||.:...|.:  :|:
  Rat    21 ATSDS-IIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACE 84

  Fly    80 LIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQS-----------NRERMNHQLTVN 133
            |:..|:.|:......|::..::.|.:...||||..    |:|           .|...|...|::
  Rat    85 LMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFI----QRSTAGTPRSGCGLTRSNRNDDYTLS 145

  Fly   134 VAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFERG---- 194
            |.| .::|:.....::..  :.|:.|.|.|:....:..:|..|.........:.:|:.|..
  Rat   146 VRP-PVYLNEVILRVVTE--YAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKM 207

  Fly   195 -----DDYRILWKRINNARE---KFVLLDCPS---DILVDVINASIGYNMTGSFNHLFLTNLDTH 248
                 |..||  :.:|..|:   :.:|:..|:   ..:.:|:..    |:.....|..:.|.:.:
  Rat   208 ITTLFDTMRI--EELNRYRDTLRRAILVMNPATAKSFISEVVET----NLVAFDCHWIIINEEIN 266

  Fly   249 LSGIDGFYSRD---FTVAVAAVRIRTYVPPPVH-----------------DEIDVFDNSVDTRFS 293
            ...:.....|.   .|:      ||...|.|.:                 |..|.|..:::
  Rat   267 DVDVQELVRRSIGRLTI------IRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNME---- 321

  Fly   294 SLGSQLVYDSIVLFYNAL-LEISQRPGFYIPNFSCGRGF---WQPGPRLVEQMKQITPKMVKPPF 354
             :.:..:||:::|..||. .::..|....:.:.||.|..   ||.|..::|.:|:.....:
  Rat   322 -ISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGL---- 381

  Fly   355 KTQRLQINADGQREDFNLEV----YNPIIDRVTH---IWNKEFQLVDFEKLRENSTQALKQKRLQ 412
             |..|:...:|...:.:.|:    |...:.|...   .||....|          ..:|..|:|:
  Rat   382 -TGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGL----------NGSLTDKKLE 435

  Fly   413 NKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVR 477
            |    :.:.:...|.|.:.:|:....|...|    ..::::|:::|::..|:....|::......
  Rat   436 N----NMRGVVLRVVTVLEEPFVMVSENVLG----KPKKYQGFSIDVLDALSNYLGFNYEIYVAP 492

  Fly   478 DNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPK 542
            |:|||| ......|:|::.:|:...|.|||..||||..|.:|||||..:|...:.:| .:.....
  Rat   493 DHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVL-LRRAEKT 555

  Fly   543 ADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWL 607
            .|::|.|.|::..:|..:...:::... |::.     ..|..|   ...:|.......|.|::|.
  Rat   556 VDMFACLAPFDLSLWACIAGTVLLVGL-LVYL-----LNWLNP---PRLQMGSMTSTTLYNSMWF 611

  Fly   608 VLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNK 672
            |.||.:.||.::....|..|::...||:|||::..:|.|.||||:|.::|...|.||.||..|..
  Rat   612 VYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTD 676

  Fly   673 VQFGTIRGGAT---------------SVY------FSESNDTDNRMAWNKMLSFKPDAFTKNNEE 716
            :.:||:...|.               |:|      .:.||.::|.:.              .::.
  Rat   677 IPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL--------------ESQA 727

  Fly   717 GVDRVKLSKGTYAFLMETTNLQYYV--QRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILR 779
            |:.:||.  |.|||:.:...|:|..  ..:|....:|.:..::.||||:...:.:|...|..||.
  Rat   728 GIQKVKY--GNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILE 790

  Fly   780 LSERGELFKLRNKWFNSNESTCD--SNVPTID-DGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFL 841
            |.:.|::..|::||:..| ..||  |:|.... .|..|:.|:.|:|.:|..|:|:..:|.|.|..
  Rat   791 LQQSGDMDILKHKWWPKN-GQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETW 854

  Fly   842 WHVQ---RISVKE 851
            |..:   |:..||
  Rat   855 WSRRKGSRVPSKE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	84/426 (20%)
		ANF_receptor	41..378	CDD:279440	75/393 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	103/395 (26%)
		Lig_chan	555..822	CDD:278489	75/292 (26%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		69/345 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	85/439 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	103/396 (26%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740