DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and si:ch211-251b21.1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001138274.1	Gene:	si:ch211-251b21.1 / 571720	ZFINID:	ZDB-GENE-060809-5	Length:	458	Species:	Danio rerio

Alignment Length:	444	Identity:	130/444 - (29%)
Similarity:	235/444 - (52%)	Gaps:	30/444 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 KPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSY 484
            :|::.|..          :|||..:. :|:| .||:.:|::..::.:..|.::...|:|.:||..
Zfish    23 QPLKVTTI----------KEEPYAMS-KGSE-LEGFCIDMLSAISNKLGFKYDVHLVKDGRYGKT 75

  Fly   485 DANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKE-PPPKADIYAF 548
            | ::..|:|:|.:::...|.|.:..||:|..|.:|||.:.||||.|:|.:..|: ....:...:.
Zfish    76 D-DSGNWNGMIGEVVRGEADIAVAPLTLTAQREAVVDMSKPFMQTGLSFIMRKDLGSDDSQFLSL 139

  Fly   549 LNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSML 613
            |..::.|:|:.|::|.::|:..:....||...||:||.::       .|.:.||::.|..:|::.
Zfish   140 LKLFSTEMWMGVLVAYLLTSICIFLVSRISPCEWEQPEKD-------NNSFTLSHSFWYTVGALT 197

  Fly   614 NQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTI 678
            .||....|:.|..|::|:.||||:|::...|.|.|:.::.|......|.:..||.:||.:::|||
Zfish   198 LQGAGPHPKALSGRVITSIWWIFSLVLLACYFANLSLWLHSDNQQLSIKTFEDLANQNVIEYGTI 262

  Fly   679 RGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQR 743
            :..::..:|..||:......:..:.  :..:::.|..||..|.:  ||.|||:.|:.:|...|.|
Zfish   263 KDSSSFNFFKNSNNPTYHRIYEHIK--EAQSYSLNAAEGFRRAQ--KGNYAFIGESVSLDLAVAR 323

  Fly   744 NCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTI 808
            .|.||:..|..|.:.|.||.||.:....||||.||||||.|||...|:||:.|:....||....:
Zfish   324 YCNLTRAPEIIGMRGYSIAAPLGSPLIKNLSVAILRLSESGELDYFRSKWWASSCVAKDSKGAPL 388

  Fly   809 DDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAE 862
            ...     |:.|:|::|..|:.:|:.:.:.|.....::::..|:......:.||
Zfish   389 KPA-----SLKGVFLLLAFGLGLGIFLALMELAAKSRKVANSEQKSCCSVMSAE 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	116/373 (31%)
		Lig_chan	555..822	CDD:278489	86/266 (32%)
si:ch211-251b21.1	NP_001138274.1	PBP2_iGluR_non_NMDA_like	25..375	CDD:270403	116/373 (31%)
si:ch211-251b21.1	NP_001138274.1	Lig_chan	146..396	CDD:278489	85/265 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770