DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grin2ab

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	1007	Identity:	211/1007 - (20%)
Similarity:	388/1007 - (38%)	Gaps:	233/1007 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVD 68
            ::.:||.||...|.|.|....:.|..|...|    .....:||.....|...|.:..:...|...
Zfish     6 VRLMVLWALLGGSQAAEKPPSLSIAVILGQT----PTVSESALRPARGIGAPLDVTVLSIQVNQT 66

  Fly    69 DSIVLQDISCDLIG----SGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMN-- 127
            |...:....|:|:.    .|:....|...:..:.:::.:.:.|.:|.|........:..|:.:
Zfish    67 DPGSMLTHLCELMSRQRLHGLVYGDGTDQEAVAQMLDFVSSQTSMPILGIHGGSAMTMAEKDSSS 131

  Fly   128 --HQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYER--------SSHLIRLQH-ILAWK-- 179
              .|...::....|.:.|...:      :||..|::...:        ::..:.:.| .:.|.
Zfish   132 SFFQFGASLQQEALLMLAIMEE------YDWHVFSVVTTKFPGFQEFIATVRVTVDHSFVRWDLQ 190

  Fly   180 ---QLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLF 241
               .|...|      |..|...:..|||   :...:||.|..|....|:..:....:||:.....
Zfish   191 SVVTLDGVG------EPEDRAHVQLKRI---QSPVILLYCSKDEAALVMEEARSLGLTGAGFVWI 246

  Fly   242 LTNLDT-HLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIV 305
            :.:|.| :|..|    ...|...:.:|   ||         |.:|..::||        :.|::.
Zfish   247 VPSLTTGNLEHI----PEAFPAGMISV---TY---------DEWDYPLETR--------LQDAVG 287

  Fly   306 LFYNALLEISQRPGFYIPN--FSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQR--LQINADGQ 366
            :..:|...:.:..| .||:  .||   :.|            :.|...||...:|  :.:|..|:
Zfish   288 IISSAAAAMFREEG-RIPDGTASC---YGQ------------SEKPEVPPSALRRYMMGVNLGGK 336

  Fly   367 REDFNLEVY--NPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQK-----RLQNKEDFSQKPIRY 424
            ...|..:.|  ||.:  |..:.|.|   .::||:......:|:.|     |..:..|........
Zfish   337 DHSFMDDGYQVNPKL--VVIVLNTE---REWEKMGRWENHSLRLKFPVWPRYNSFGDMDADENHL 396

  Fly   425 TVATRVGKPYF------------SWREEPEGVHYEGN--------ERFEGYAVDLIYMLAQECKF 469
            ::.|...:|:.            .....|...|.:.|        :..:|:.:|::..:|:..||
Zfish   397 SIVTLEERPFVIVDDVDILTGTCMRNSVPCRKHIKDNTTEGSYVKKCCKGFCIDILKKIARNVKF 461

  Fly   470 DFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL 534
            .::...|.:.|:|....|.  |:|::.:::...|.:.:..|||.:.|...:||:|||::.|||::
Zfish   462 TYDLYLVTNGKHGKKINNV--WNGMVGEVVYKKAVMAVGSLTINEERSEAIDFSVPFVETGISVM 524

  Fly   535 ---SYKEPPPKADIYAFLNPYNAEVW--LFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREME 594
               |.....|.    |||.|::|.||  :|||: :::||.|:..      :|:..|: ..||.:.
Zfish   525 VSRSNGTVSPS----AFLEPFSASVWVMMFVML-LIVTAIAVFL------FEFISPL-GFNRNLA 577

  Fly   595 RQNIWH-----LSNALWLVLGSMLNQGCDLL-PRGLPMRLLTAFWWIFALLISQTYIAKLAAFIT 653
            :....|     :..|:||:.|.:.|....:. |||...:.:.:.|..||::...:|.|.||||:.
Zfish   578 QGKDPHGPSFTIGKAVWLLWGLVFNNSVPVQNPRGTTSKFIVSVWAFFAVIFLASYTANLAAFMI 642

  Fly   654 SSKIAGDIGSLHDLVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTK 712
            ..:....:..|.|...|:      ..:|||:..|:|     |.|...|..|.::.:       .|
Zfish   643 QEEFVDQVTGLSDRKFQSPYSYSPPFRFGTVPNGST-----ERNIRKNYPAMHQYM-------VK 695

  Fly   713 NNEEGV--DRVKLSKGTY-AFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGIAVPLNADFR 770
            .::.||  ..|.|..|.. ||:.:...|.|...|:  |:|..||..  |....||||:...:.::
Zfish   696 YHQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIGSGYIFATTGYGIAMQKGSYWK 760

  Fly   771 SNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVI 835
            ..:.:.||.:...||:.:|..:|..   ..|.:....:...|.|:|::.|:|.:|...:.:.|:
Zfish   761 RLVDLAILGIIGDGEMEELEAQWLT---GICHNEKNEVMSSQLDVDNMAGVFYMLAAAMALSLI- 821

  Fly   836 GVAEFLW-HVQRISVKEKIPPMLALKAEFYFVIRF--------------------W--------- 870
               .|:| |:                  ||:.:|:                    |
Zfish   822 ---TFVWEHL------------------FYWRLRYCFTGLCSGRPGILFTISRGIWSCIHGVHIE 865

  Fly   871 LTRKP----------LHTYRQSRDSTSTGYSS 892
            |.:.|          ||..:.:::.|:.|.:|
Zfish   866 LKKAPELDFSPQANMLHLLKSAKEITTLGVTS 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	72/395 (18%)
		ANF_receptor	41..378	CDD:279440	65/365 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	104/416 (25%)
		Lig_chan	555..822	CDD:278489	73/287 (25%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	76/420 (18%)
		ANF_receptor	48..358	CDD:279440	65/366 (18%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	105/425 (25%)
		Lig_chan	544..816	CDD:278489	75/294 (26%)
		NMDAR2_C	827..1445	CDD:287527	12/89 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930