Protein Alignment GluRIIB and grin3ba

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_021323058.1
• Gene: grin3ba / 566411
• ZFINID: ZDB-GENE-070912-354
• Length: 1118
• Species: Danio rerio
• Alignment Length: 1030
• Identity: 215/1030 - (20%)
• Similarity: 379/1030 - (36%)
• Gaps: 279/1030 - (27%)

  Fly    25 IKIGAIF-FDTEMKLADAFSAALEEV-----NAINPALKLDAIKRY-VTVDDSIVLQDISCDLIG 82
            :::||:. ...:.::..|.:.||..:     |.:...|.|:.:.|. :..|...:.:.:..|::.
Zfish    44 VRLGALLPTRQQSRIQGALNRALVHLRQSGNNFLPYNLSLEVLSREPLNGDPESMFRCVCQDIVV 108

  Fly    83 SGVAAIFG-PSSKTNSDIVEVLCNMTGIPHLQF--DWHPQQSNRERMNHQLTVNVAPMELFLSAA 144
            .||:|:.. |.|......||.:.:...||.:..  ...|.:: :.|.:.|:...:.|      :.
Zfish   109 QGVSAVLAFPQSHEELIQVEFMSSFLEIPFISIIEQGEPLKT-QNRFHLQMMTRMPP------SG 166

  Fly   145 FSDILASKTF--DWK--SFTIA-----------YERSSHL-IRLQHILAWKQLHKAGIKMQEFER 193
            .||:|.:...  .|:  :.|:.           .::..|| :...|...|:.|:.:.::    |.
Zfish   167 LSDLLLAVLLRGGWQGGAATVCPGGGNTGMLEELQQRGHLGLDGAHWHLWETLNLSRLE----EN 227

  Fly   194 GDDYRI------LWKRINNAREKFVLL-----DCPSDIL-------------------------V 222
            ..:.::      |..|..:|....|:|     :|.:.:|                         :
Zfish   228 ISEDKVMELLSQLLSRTPSAPASSVVLFGSDPECTATVLHCAHQLSGTLPPMHWIMGYPLSLDSL 292

  Fly   223 DVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVA-AVRIRTYVPPP---VHDEIDV 283
            ..|.:.:|....|..|...|           .||.||....:. ||...|.|.|.   :.:.::.
Zfish   293 HSIGSPLGLMAYGEVNRKPL-----------NFYIRDTLQLIGRAVYAATMVRPDLALIQNMVNC 346

  Fly   284 FDNSVDTRFSSLGSQLV--------------------------------------------YDSI 304
            ||........|.|..|.                                            :.::
Zfish   347 FDKPNKHELPSSGQYLARFLSNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTV 411

  Fly   305 VLFYNALLEISQR---PGFYI------PNFSCGRGFWQPG-PRLVEQMKQITPKMVKPPFKTQRL 359
            ..:.:..||:.::   ||...      |....| |.||.| |....:::.:|  :|:.||...|
Zfish   412 ASWQSGRLELEEQGLWPGVTQHQREDGPGIRLG-GRWQAGLPVAGSRLRVVT--LVEHPFVFTR- 472

  Fly   360 QINADGQ---------REDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKE 415
            :::.:||         .:..|.||.|.:                |.:|.:.::.:|
Zfish   473 EVDEEGQCPAGQLCLDPQTNNSEVLNQL----------------FRELEQTNSSSL--------- 512

  Fly   416 DFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNK 480
                       .|.:.|..:                  ||.:||:..||::..|:|:...|.|.|
Zfish   513 -----------PTDMRKCCY------------------GYCIDLLEKLAEDMHFEFDLYIVGDGK 548

  Fly   481 YGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADI 545
            ||::...  .|.|::..|:...|.:.:...:|..||..|:|||.||....:.|| .:.....|.|
Zfish   549 YGAWKGG--RWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGIL-VRSKDTAAPI 610

  Fly   546 YAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLG 610
            .||:.|.:..:|:.:.:|:.|||   :|   |..|||:.|.........|..::..|:||.|...
Zfish   611 GAFMWPLHWSMWVGIFVALHITA---LF---ITLYEWNSPFGMTPHGRNRIRVFSYSSALNLCYA 669

  Fly   611 SMLNQG-CDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNK-- 672
            .:..:. ....|:....|.|...|.||.||:..:|.|.|||.:...|...::..:||:...:.
Zfish   670 ILFGRTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHPSL 734

  Fly   673 -VQFGTIRGGATSVY----FSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTY-AFL 731
             .:|||:|..:...|    |.|.::...|  :||..:  ||        ||..:|...... ||:
Zfish   735 GFRFGTVRESSAEDYVKKSFPEMHEYMRR--FNKPTT--PD--------GVSTLKTDPPQLDAFI 787

  Fly   732 METTNLQYYV--QRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWF 794
            |:...|.|.|  ..:|:|..:|:.|..:.|||.:|.|:....|:|..:.|....|.:..|.:||:
Zfish   788 MDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWY 852

  Fly   795 NSNESTCDSNVPTIDDG-QFDMDSVGGLFVVLIVGVVVGLVIGVAE---------FLWHVQRISV 849
              ....|...|..:.:. |..:....||||:|.|||...|:..:.|         .|.|.||
Zfish   853 --KVVPCGKRVFAVTETLQMGIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQR--- 912

  Fly   850 KEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKK 904
                             .::|     |||.::...:.:.|... |:.:.|.|:.:
Zfish   913 -----------------FKYW-----LHTSQKIHRAINMGCDD-ERKSEAESSDR 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	83/495 (17%)
		ANF_receptor	41..378	CDD:279440	81/464 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	104/383 (27%)
		Lig_chan	555..822	CDD:278489	73/278 (26%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	63/405 (16%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	117/472 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740