DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grin3a

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	1033	Identity:	211/1033 - (20%)
Similarity:	361/1033 - (34%)	Gaps:	259/1033 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IKIGAIFFDTEMKLADAFSA-------------------------------ALEEVNAINPALKL 58
            :::||:.....:...|:||.                               ....||.:|.|.|.
Zfish    50 VRVGALHLQPRVFRQDSFSGRDLDWDADREMWEEWDVIFQSDHEEDWRGIRTKSSVNNLNKASKS 114

  Fly    59 DAIKRYVTVD------DSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWH 117
            ..:.:.|..|      ||::|...|.    :.||.:. |.:.|...::.|...:..:|...|
Zfish   115 KTVLKQVAPDVVFLPRDSVLLASESL----NRVAGLL-PYNLTLEIVMAVEAGLGELPAFSF--- 171

  Fly   118 PQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLH 182
                     :...|...|....||.:....::........||.   :....|::|:.|.:..|:.
Zfish   172 ---------SSSSTPACADPVSFLQSVCHTVIVQGVSAIISFP---QNRDELVKLEFIASTLQIP 224

  Fly   183 KAGIKMQEFERGDDYRILWK------RINNAREKFVLLDC-----PSDILVDVINASIGYNMTGS 236
            ...:...||:|.....:.::      :.:.|...|.||..     .|.::...:|.|       .
Zfish   225 VISVVQSEFQRQTQNLLHFQMAMQNPQTSQANLIFSLLSMNNWFDVSLVMCQQMNIS-------D 282

  Fly   237 FNHLFLTNLDTHLSGI-----DGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLG 296
            |..|...|...||..:     :.....||.:.:.|             :::...:|..| ..:.|
Zfish   283 FVFLLHNNSKFHLGTVLKISTNSSSKNDFHIFLQA-------------QLESIKDSTST-LVTFG 333

  Fly   297 SQL-----VYDSIVLF------YNALLEISQR------PGFYIPNFSCGRGFWQPG--------- 335
            ..:     ::.:|..|      |:.::..||.      .|..:...:.|| ..:|.
Zfish   334 CDIRDIRRIFTTIAKFGLILPDYHWIIGDSQNVEELRTEGLPMGLLAHGR-MGEPSLDHYVQDAL 397

  Fly   336 ---PRLVEQMKQITPKMVKPPFKTQ---RLQ----------------INADGQREDFNLEVYNPI 378
               .|.|.....::|::...|..|.   ||:                .:.||.....:::..:.|
Zfish   398 ELVARAVGSAATVSPQLALIPGTTNCLARLEAKNLTSGTFLSRYMASTSFDGLSGCISVQEESTI 462

  Fly   379 IDRVTH-IWNKEFQLVDFEK-LRENSTQALK----------QKRLQNKEDFSQKP-IRYTVATRV 430
            |....| |||.:...:.... .|..|.:..|          ::|.|...|:.... :...|.|.|
Zfish   463 ISESHHFIWNLQHDPIGKPMWTRLGSWKHGKVVMDYGVWPNKRRSQPGADWRHSSRLHLRVVTLV 527

  Fly   431 GKPYFSWRE-EPEG--------------------------------VHYEGNERFEGYAVDLIYM 462
            ..|:...|: :.||                                |..|..:...||.:||:..
Zfish   528 EHPFVFTRDVDDEGLCPAGQLCLDPLTNDTALLESLFQGLQGANDTVPLEFKKCCYGYCIDLLEK 592

  Fly   463 LAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFM 527
            ||::..|||:...|.|.|||:|  ....|.|::..|:...|.:.:...:|..||..|:|||.||.
Zfish   593 LAEDMGFDFDLYIVGDGKYGAY--KNGRWTGLVGDLMSGAAHLAVTSFSINSARSQVIDFTSPFF 655

  Fly   528 QLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE 592
            ...:.|| .:.....|.|.||:.|.:..:||.:.:::.:||..|..      |||..|.....|.
Zfish   656 STSLGIL-VRTRDTAAPIGAFMWPLHWSMWLGIFVSLHVTAVFLTL------YEWKSPFGMTPRG 713

  Fly   593 MERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPM----RLLTAFWWIFALLISQTYIAKLAAFIT 653
            ..|..::..|:||.:....:..:...:.|   |.    |.|...|.||.|....||.|.|||.:.
Zfish   714 RNRDRVFSFSSALNVCYAILFGRTAAIKP---PKCWTGRFLMNLWAIFCLFCLSTYTANLAAVMV 775

  Fly   654 SSKIAGDIGSLHDLVDQNKVQ---FGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNE 715
            ..|....:..:||....:..|   |||:|..:...|..:|        :.:|..:..........
Zfish   776 GEKTYEQLSGIHDPKLHHPSQGFRFGTVRESSAEDYVKKS--------FPEMHEYMRRYNAPTTP 832

  Fly   716 EGVDRVKLS-KGTYAFLMETTNLQYYVQRN---CELTQIGESFGEKHYGIAVPLNADFRSNLSVG 776
            :|:|.:|.. :...||:|:...|.|:...:   ..|...|       |||.:..|:...||:|..
Zfish   833 DGIDHLKDDPQKLDAFIMDKALLDYWAHADKXYISLLLTG-------YGIGLKQNSPLTSNISEL 890

  Fly   777 ILRLSERGELFKLRNKWFNSNESTCDSNVP-------TIDDGQFDMDSVGGLFVVLIVGVVVGLV 834
            :.:....|.:..|.:||:..        ||       ..:..|..:....||||:|.|||.:.|:
Zfish   891 VSQYKSDGFMDMLHDKWYKV--------VPCGKRSFAVTETLQMGIKHFSGLFVMLCVGVALSLL 947

  Fly   835 IGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWL-TRKPLH-----TYRQSRDST 886
            ..:.|.:.|       ..:.|.:....|.    ::|| |.:.||     |:::.:..|
Zfish   948 TTLGEHIVH-------RWVIPRMQESTEH----KYWLHTSQRLHRALNPTFKEDKLQT 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	78/468 (17%)
		ANF_receptor	41..378	CDD:279440	69/437 (16%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	104/416 (25%)
		Lig_chan	555..822	CDD:278489	64/284 (23%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	81/493 (16%)
		ANF_receptor	132..452	CDD:279440	59/361 (16%)
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	103/416 (25%)
		Lig_chan	682..941	CDD:278489	68/290 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740