DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grin2bb

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	971	Identity:	217/971 - (22%)
Similarity:	390/971 - (40%)	Gaps:	213/971 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIKIGAIFFDTEMKLADAFSAALEEVNAINPAL--KLDAIKRYVTVDDSIVLQDISCDLIG---- 82
            ||.:|.   .:|:.|    |..||:.:.::..|  |::.:....|...||:  :..|.|:.
Zfish   113 VILVGN---SSEVSL----SEGLEKEDFLHVPLPPKVELVTMNETDPKSII--NRICALMSRNWL 168

  Fly    83 SGVAAIFGPSS--KTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAF 145
            .||  :||..:  :..:.|::.:...|.||.|............:.:|.:.....|.....::..
Zfish   169 QGV--VFGDDTDQEAIAQILDFISAQTHIPILGIRGGSSMIMAAKDDHSMFFQFGPSIEQQASVM 231

  Fly   146 SDILASKTFDWKSFTI------AYERSSHLIRL---QHILAWKQLHKAGIKMQEFERGDDYRILW 201
            .:|:  :.:||..|:|      .::...:.||.   ...:.| :|.:..:.....:.||
Zfish   232 LNIM--EEYDWYIFSIVTTYYPGHQDFVNRIRSTVDNSFVGW-ELEEVLLLDMSVDDGD------ 287

  Fly   202 KRINNAREKF----VLLDCPSDILVDVINASIGYNMTG----------------SFNHLFLTNL- 245
            .:|.|..:|.    :||.|..:....:...:....:||                :..::|.|.|
Zfish   288 SKIQNQMKKLQSPVILLYCTKEEATTIFEVAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPTGLI 352

  Fly   246 ----DTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSS--------LGSQ 298
                |....|::. ..|| .||:.|:...|.          :.|....|...|        .||:
Zfish   353 SVSYDEWDYGLEA-RVRD-AVAIIAMATSTM----------MLDRGPHTLLKSGCHGAPDKKGSK 405

  Fly   299 LVYDSIVLFYNALLEISQRPGFYIPNFSCGRGFWQPGPRLV------EQMKQITPKMVKPPFKTQ 357
            ....:.||.|  |:.::    |...|.|.....:|..|:||      |:..:...|........:
Zfish   406 SGNPNEVLRY--LMNVT----FEGRNLSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMK 464

  Fly   358 -----RLQINADG-QREDFNLEVYNPIIDRVTHIWNKEFQLV-DFEKL----RENSTQALKQKRL 411
                 |.::.:|. :|||.:|.:       || :....|.:| |.:.|    ..|:....||.:|
Zfish   465 YHVWPRFELYSDAEEREDDHLSI-------VT-LEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKL 521

  Fly   412 QNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPV 476
            ||....|                        |::.:  ...:|:.:|::..:|:..||.::...|
Zfish   522 QNLTGDS------------------------GIYIK--RCCKGFCIDILKKIAKSVKFTYDLYLV 560

  Fly   477 RDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL---SYKE 538
            .:.|:|.....|  |:|::.:::..||.:.:..|||.:.|..|:||:|||::.|||::   |...
Zfish   561 TNGKHGKKINGT--WNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGT 623

  Fly   539 PPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQN-----I 598
            ..|.    |||.|::|:||:.:.:.::|.:...:|.     :|:..|| ..||.:....     .
Zfish   624 VSPS----AFLEPFSADVWVMMFVMLLIVSAVAVFV-----FEYFSPV-GYNRCLADGREPGGPS 678

  Fly   599 WHLSNALWLVLGSMLNQGCDLL-PRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIG 662
            :.:..|:||:.|.:.|....:. |:|...:::.:.|..||::...:|.|.||||:...:....:.
Zfish   679 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVT 743

  Fly   663 SLHDLVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRV 721
            .|.|...|:      ..:|||:..|:|     |.|..:|   :.:|.|:......||..|.:..:
Zfish   744 GLSDKKFQHPNDFSPPFRFGTVPNGST-----ERNIRNN---YKEMHSYMTSFHQKNVNEALHSL 800

  Fly   722 KLSKGTYAFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSE 782
            |..| ..||:.:...|.|...|:  |:|..||..  |....||||:..::.::..:.:.||:|..
Zfish   801 KSGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFG 864

  Fly   783 RGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRI 847
            .||:.:|...|..   ..|.:....:...|.|:|::.|:|.:|...:.:.|:..:||.|
Zfish   865 DGEMEELEALWLT---GICHNEKNEVMSSQLDVDNMAGVFYMLGAAMALSLITFIAEHL------ 920

  Fly   848 SVKEKIPPMLALKAEFYFVIRFWL----TRKPLHTYRQSRDSTSTGYSSLE--QITSASSA 902
                           ||:.:||..    :.||..|:..||..    ||.:.  ||....||
Zfish   921 ---------------FYWQLRFCFMGVCSGKPGMTFSISRGI----YSCIHGVQIEENKSA 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	81/428 (19%)
		ANF_receptor	41..378	CDD:279440	75/398 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	98/391 (25%)
		Lig_chan	555..822	CDD:278489	69/282 (24%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	74/394 (19%)
		ANF_receptor	138..442	CDD:279440	64/334 (19%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	114/457 (25%)
		Lig_chan	636..908	CDD:278489	71/289 (25%)
		NMDAR2_C	919..1770	CDD:287527	16/69 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740