DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grid1b

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_009304811.1	Gene:	grid1b / 557511	ZFINID:	ZDB-GENE-121214-84	Length:	1048	Species:	Danio rerio

Alignment Length:	971	Identity:	225/971 - (23%)
Similarity:	406/971 - (41%)	Gaps:	149/971 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLALAI--ASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIK---RYVT 66
            ::.|:..|  .|.|..|: :|.|||||.:...:..:.|..|:.:::..:..|:.:.|.   :|:.
Zfish     5 IICLSFGILQCSSAGADS-IIHIGAIFEENAARDDEVFQLAISDLSLNDDILQSEKITHSIKYIE 68

  Fly    67 VDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLT 131
            .::.......:|:|:..|:.|:...:...::..::.|.:...||||....:.:.|.|....
Zfish    69 PNNPFQAVQEACELMTQGILALVTSTGCASASALQSLTDAMHIPHLYVQRNAEGSPRTACQ---- 129

  Fly   132 VNVAP-MELFLSAA-----FSDILASKTFD--WKSFTIAYERSSHLIRLQHILAWKQLHKAGIKM 188
            :|.:| .|.:..||     ..|::.:...:  |:.|.:.|:....:..||..|.........:.:
Zfish   130 LNPSPDGERYTLAARPPVRLGDVMLTLVGELRWQKFIVFYDSDYDIRGLQVFLDQTSRQGLDVSL 194

  Fly   189 QEFERGDD--YRILW-----KRINNARE---KFVLLDCPSDILVDVINASIGYNMTGSFNHLFLT 243
            |..:|...  :..|:     :.:|..|:   :.:||..|....| .|:.::..|:....:|....
Zfish   195 QRVDRNISGVFSSLFTSMRTEELNRYRDTLRRAILLLSPRGAQV-FIHQAVETNLASKDSHWVFV 258

  Fly   244 N---LDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSL---------- 295
            |   .||.:..:........||      :|...|......:....||  .|.|||
Zfish   259 NEEISDTEILELAHSSLGRMTV------VRQIFPLWRDSSVSCMRNS--HRISSLLCDPQEGYLQ 315

  Fly   296 ----GSQLVYDSIVLFYNALL-EISQRPGFYIPNFSCGRGF---WQPGPRLVE--QMKQITPKMV 350
                .:..:|||:::..||.. ::..|....:.:.:|.|..   |..|..::|  |..:||....
Zfish   316 SLEVSNLYLYDSVLMLANAFYRKLEDRKWHSMASLNCIRKSTKPWNGGWSMLETIQKGRITGLTG 380

  Fly   351 KPPFKTQRLQINADGQREDFNL------EVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQK 409
            ...|..     |.......|.:      |.:...|.|:. .|:....|          ..:||:.
Zfish   381 IMDFME-----NGSNSHVQFEILGTSFSETFGKDIKRLA-TWDSVHGL----------NGSLKES 429

  Fly   410 RLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFE 474
            |::|    ..:.:...|.|.:..|:....|...|    ..:|::|:::|::..||:...|.::..
Zfish   430 RIEN----GMQGVTVKVVTLLEDPFVMVAENILG----QPKRYKGFSIDVLEALAKILGFKYDIY 486

  Fly   475 PVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEP 539
            .|.|:||||..:| ..|:|:|.:||:..|.:.:..:|||..|.:||||:..:|...:.|| :::|
Zfish   487 QVADSKYGSQLSN-GSWNGMIGELINKRADLAVSAITITPERENVVDFSKRYMDYSVGIL-HRKP 549

  Fly   540 PPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNA 604
            ..|.:|::...|::..||..:..|:.:....:....|:.......| ...:......|..|  :|
Zfish   550 EEKINIFSLFAPFDLAVWACIAAAIPVVGVLIFLLTRMQMLRSQNP-PGAHHASSMSNSLH--SA 611

  Fly   605 LWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVD 669
            :|:|.|:.:.||.|.:...:.:|::...||:|.|::..:|.|.||||:|.|::...|.:..||..
Zfish   612 IWIVYGAFVQQGGDSVVGSVALRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNTIRTFQDLAR 676

  Fly   670 QNKVQFGTIRGGATSVYFSESN----DTDNRMA--WNKMLSFKPDAFTKNN---------EEGVD 719
            |....:||:|..|...||....    :.|:..|  |.        ..:|||         .||:.
Zfish   677 QMDFAYGTVRDSAVYDYFKAKGTNPLEQDSTYAELWR--------TISKNNGQDFSVSSPSEGIR 733

  Fly   720 RVKLSKGTYAFLMETTNLQY--YVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSE 782
            :.|  ||.||||.:...::|  ....:|.:|..|.|...|.||||:...:.:|..:|..||.|.|
Zfish   734 KAK--KGPYAFLWDMAVVEYAALTDDDCTITVSGNSMSSKGYGIAMQHGSPYRDLISQKILELQE 796

  Fly   783 RGELFKLRNKWFNSNESTCDSNVPT---IDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHV 844
            :|:|..|:.||: .....||.|..:   .|.....:.|..|:|.:|..|:::..::...|..|:.
Zfish   797 KGDLDVLKQKWW-PRTGRCDLNSHSNAQPDGRSLKLHSFAGVFCILAAGLLLACLVAALEMWWNS 860

  Fly   845 QRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKK 905
            .|  .:::.|                  ::....||.:|.|....|:   .|.:|||...|
Zfish   861 NR--CRQEQP------------------KEVTKDYRLARVSGPLTYN---DIATASSEGSK 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	79/416 (19%)
		ANF_receptor	41..378	CDD:279440	71/386 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	112/389 (29%)
		Lig_chan	555..822	CDD:278489	79/286 (28%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	80/427 (19%)
		ANF_receptor	36..400	CDD:279440	70/381 (18%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	112/391 (29%)
		Lig_chan	565..840	CDD:278489	80/288 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740