DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grik2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	927	Identity:	265/927 - (28%)
Similarity:	452/927 - (48%)	Gaps:	97/927 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLALAIASGANEDTLVIKIGAIFFDTEMKLAD----AFSAALEEVN-----AINPALKLDAIK 62
            |:||.:..:.|...   |::.|.||...|...:.    ||..||..:|     ..|..|..| |:
Zfish    21 LLLLCVGYSHGMPH---VLRFGGIFESIESGPSGAEELAFKFALNTINRNRTLLPNTTLTYD-IQ 81

  Fly    63 RYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQSNRERM 126
            | :.:.||......:||.:..|||||||||..::::.|:.:||..|:||:|..| |....||:
Zfish    82 R-INIHDSFEASRKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQVSDNRD-- 143

  Fly   127 NHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEF 191
              ...||:.|....||.|..|::  ..|.||:.|:.|:.|:.|||||.::.....:...:|:::.
Zfish   144 --SFYVNLYPDFSSLSRAILDLV--HFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNIRLKIRQL 204

  Fly   192 ERG-DDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF 255
            ... .|.:.|.|.:...:|..|:.||..::...::..::...|...:.|...|.||.....::.:
Zfish   205 PADTKDAKPLLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPY 269

  Fly   256 -YSRDFTVAVAAVRI------------------RTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVY 301
             ||   .|.:...||                  |...||..       |:.:...|.:..:.|:|
Zfish   270 RYS---GVNMTGFRILNTENSQVSSIIEKWSMERLQAPPKP-------DSGLLDGFMTTDAALMY 324

  Fly   302 DSIVLFYNALLEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN-AD 364
            |::   :...:.:.|.|...:.:..|.|.. |:.|.|.:..:|:.....:     |.|:..| .:
Zfish   325 DAV---HVVAVAVQQSPQITVSSLQCNRHKPWRFGNRFMTLIKEAHWDGL-----TGRINFNRTN 381

  Fly   365 GQREDFNLEVYNPIIDRVTHI--WNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVA 427
            |.|.||:|:|.:...:.:..|  |:....|        |.|:..|.|.....:..|.:.:  .|:
Zfish   382 GLRTDFDLDVISLKEEGLEKIGTWDPASGL--------NMTENQKGKTANVTDSLSNRSL--VVS 436

  Fly   428 TRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWD 492
            |.:.:||..:::..:.::  ||:|||||.|||:..||....|.:....|.|.:||:.|.::.:|:
Zfish   437 TILEEPYVMFKKSDKPLY--GNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWN 499

  Fly   493 GIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVW 557
            |::|:|:|:.|.:.:..|.||..|..|:||:.|||.||||||..|.......:::||||.:.::|
Zfish   500 GMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIW 564

  Fly   558 LFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSNALWLVLGSMLNQGCDLLP 621
            :::::|.:..:..|....|...|||..|.. |.:.::...| :.|.|:.|..:|:::.||.:|:|
Zfish   565 MYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENN-FTLLNSFWFGVGALMQQGSELMP 628

  Fly   622 RGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVY 686
            :.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.|:::|.:..|:|..:
Zfish   629 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTF 693

  Fly   687 FSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIG 751
            |.::..:.....|..|.|.:.....|:.|||::||..|  .||||||:|.:::..||||.|||||
Zfish   694 FKKTKISTYDKMWEFMSSRRHSVMVKSIEEGIERVLTS--DYAFLMESTTIEFVTQRNCNLTQIG 756

  Fly   752 ESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMD 816
            .....|.||:..|:.:.:|..:::.||:|.|.|:|..::.||:..|....:.|.   :.....:.
Zfish   757 GLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEENK---EASALGVQ 818

  Fly   817 SVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFW--LTRKP---- 875
            ::||:|:||..|:|:.:.:.|.|||:..::.:..||.....|:..|....::..  |..||
Zfish   819 NIGGIFIVLAAGLVLSVFVAVGEFLYKSKQNAQLEKRSFCSAMVDELRVSLKCQRRLKHKPQPPV 883

  Fly   876 ---------LHTYRQSR 883
                     :||:...|
Zfish   884 MVKTDEVINMHTFNDRR 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	101/400 (25%)
		ANF_receptor	41..378	CDD:279440	95/364 (26%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	130/373 (35%)
		Lig_chan	555..822	CDD:278489	85/267 (32%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	103/410 (25%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	130/376 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850