DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIB and Grik2

DIOPT Version :9

Sequence 1:NP_523485.3 Gene:GluRIIB / 33789 FlyBaseID:FBgn0020429 Length:913 Species:Drosophila melanogaster
Sequence 2:NP_062182.1 Gene:Grik2 / 54257 RGDID:2733 Length:908 Species:Rattus norvegicus


Alignment Length:932 Identity:267/932 - (28%)
Similarity:452/932 - (48%) Gaps:106/932 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VLLALAIASGANEDTLVIKIGAIFFDTEM------KLADAFSAALEEVNAIN------PALKLDA 60
            |||.|.....:...|.|::.|.||...|.      :||..|:     ||.||      |...|..
  Rat    19 VLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA-----VNTINRNRTLLPNTTLTY 78

  Fly    61 IKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRER 125
            ..:.:.:.||......:||.:..|||||||||..::::.|:.:||..|:||:|..|..|.|:.: 
  Rat    79 DTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNK- 142

  Fly   126 MNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQE 190
              ....|::.|....||.|..|::  :.|.||:.|:.|:.|:.|||||.::.....:...:|:::
  Rat   143 --DSFYVSLYPDFSSLSRAILDLV--QFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQ 203

  Fly   191 FERG-DDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDG 254
            .... .|.:.|.|.:...:|..|:.||..::...::..::...|...:.|...|.||.....::.
  Rat   204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEP 268

  Fly   255 F-YSRDFTVAVAAVRI------------------RTYVPPPVHDEIDVFDNSVDTRFSSLGSQLV 300
            : ||   .|.:...||                  |...||..       |:.:...|.:..:.|:
  Rat   269 YRYS---GVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKP-------DSGLLDGFMTTDAALM 323

  Fly   301 YDSIVLFYNALLEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN-A 363
            ||::   :...:.:.|.|...:.:..|.|.. |:.|.|.:..:|:...:.:     |.|:..| .
  Rat   324 YDAV---HVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGL-----TGRITFNKT 380

  Fly   364 DGQREDFNLEVYNPIIDRVTHI--WNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTV 426
            :|.|.||:|:|.:...:.:..|  |:....|        |.|::.|.|.....:..|.:.:  .|
  Rat   381 NGLRTDFDLDVISLKEEGLEKIGTWDPASGL--------NMTESQKGKPANITDSLSNRSL--IV 435

  Fly   427 ATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEW 491
            .|.:.:||..:::..:.::  ||:|||||.:||:..|:....|.:....|.|.|||:.|....:|
  Rat   436 TTILEEPYVLFKKSDKPLY--GNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQW 498

  Fly   492 DGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEV 556
            :|::|:|||:.|.:.:..|.||..|..|:||:.|||.||||||..|.......:::||||.:.::
  Rat   499 NGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDI 563

  Fly   557 WLFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSNALWLVLGSMLNQGCDLL 620
            |::|::|.:..:..|....|...|||..|.. |.:.::...| :.|.|:.|..:|:::.||.:|:
  Rat   564 WMYVLLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENN-FTLLNSFWFGVGALMRQGSELM 627

  Fly   621 PRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSV 685
            |:.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.|:::|.:..|||..
  Rat   628 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMT 692

  Fly   686 YFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQI 750
            :|.:|..:.....|..|.|.:.....|:||||:.||..|  .||||||:|.:::..||||.||||
  Rat   693 FFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRNCNLTQI 755

  Fly   751 GESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSN----ESTCDSNVPTIDDG 811
            |.....|.||:..|:.:.:|..:::.||:|.|.|:|..::.||:..|    |.:.:::.      
  Rat   756 GGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASA------ 814

  Fly   812 QFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFW--LTRK 874
             ..:.::||:|:||..|:|:.:.:.|.|||:..::.:..||.....|:..|....::..  |..|
  Rat   815 -LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHK 878

  Fly   875 P-------------LHTYRQSR 883
            |             :||:...|
  Rat   879 PQAPVIVKTEEVINMHTFNDRR 900

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIBNP_523485.3 PBP1_iGluR_Kainate 26..393 CDD:107377 98/402 (24%)
ANF_receptor 41..378 CDD:279440 90/364 (25%)
PBP2_iGluR_Kainate 422..795 CDD:270432 134/373 (36%)
Lig_chan 555..822 CDD:278489 89/271 (33%)
Grik2NP_062182.1 Periplasmic_Binding_Protein_Type_1 34..414 CDD:299141 101/415 (24%)
ANF_receptor 52..395 CDD:279440 92/370 (25%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:304360 134/376 (36%)
Glutamate binding. /evidence=ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C 516..518 0/1 (0%)
Lig_chan 562..831 CDD:278489 92/278 (33%)