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Protein Alignment GluRIIB and Gria3

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001268858.2	Gene:	Gria3 / 53623	MGIID:	95810	Length:	888	Species:	Mus musculus

Alignment Length:	955	Identity:	259/955 - (27%)
Similarity:	423/955 - (44%)	Gaps:	155/955 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALE----EVNAINPALKLDAIKRYVT 66
            ||||..|..:.|...:|  |.||.:|....::...||..|::    ..|.......|:....::.
Mouse    11 FLVLGLLGHSHGGFPNT--ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLD 73

  Fly    67 VDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLT 131
            ..:|..:.:..|.....||.||||...:.:.:.:...|   |..|..|   ...|.....:.|..
Mouse    74 SSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFC---GALHTSF---VTPSFPTDADVQFV 132

  Fly   132 VNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILA------WKQLHKA--GIK- 187
            :.:.|.   |..|...:|.  .:.|:.|...|:.......||.|:.      |:...::  .||
Mouse   133 IQMRPA---LKGAILSLLG--YYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKD 192

  Fly   188 MQEFERGDDYRILWKRINNAREKFVLLDCP----SDILVDVI---NASIGYNMTGSFNHLFLTNL 245
            :|||.|      :.:.::..:||..|:||.    :.||..|:   ..|.||       |..|.||
Mouse   193 IQEFRR------IIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGY-------HYMLANL 244

  Fly   246 ---DTHL-------SGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFS------- 293
               |..|       :.|.||            :|.....|.|...|..:....:..|.
Mouse   245 GFTDIVLERVMHGGANITGF------------QIVNNENPMVQQFIQRWVRLDEREFPEAKNAPL 297

  Fly   294 SLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKM 349
            ...|.|.:|:|::...|.       :::|:|  .|..:.|.:..   |..|..:...:     ||
Mouse   298 KYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVP---WSQGIDIERAL-----KM 354

  Fly   350 VKPPFKTQRLQINADGQREDFNLEVYNPII--DRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQ 412
            |:....|..:|.:..|:|.::.::||...:  .|....||:..:.|.|...:.::..:..:.|
Mouse   355 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENR-- 417

  Fly   413 NKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVR 477
                      ...|.|.:..||..:::..|  ..|||||:|||.|||.|.:|:..:..:....|.
Mouse   418 ----------TIVVTTILESPYVMYKKNHE--QLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVG 470

  Fly   478 DNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPK 542
            |.|||:.|..|..|:|::.:|:...|.|.:..||||..|..|:||:.|||.|||||:..|....|
Mouse   471 DGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 535

  Fly   543 ADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE-------MERQNIWH 600
            ..:::||:|...|:|:.::.|.:..:..|....|...|||.  :|:.|.|       .:..|.:.
Mouse   536 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH--LEDNNEEPRDPQSPPDPPNEFG 598

  Fly   601 LSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLH 665
            :.|:||..||:.:.||||:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..
Mouse   599 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAE 663

  Fly   666 DLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAF 730
            ||..|.::.:||:..|:|..:|..|........|:.|.|.:|..|||...:||.||:.|||.:||
Mouse   664 DLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAF 728

  Fly   731 LMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWF 794
            |:|:|..:|..||. |:..::|.:...|.||:|.|..:..|:.:::.:|:|||:|.|.||:|||:
Mouse   729 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWW 793

  Fly   795 NSNESTCDSNVPTIDDGQFD------MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853
             .::..|.:.    |.|..|      :.:|.|:|.:|:.|:.:.:::.:.||.:..:..|.:.|:
Mouse   794 -YDKGECGAK----DSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKL 853

  Fly   854 -------PPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYS 891
                   .|..|...:.|            .|||:       ||:
Mouse   854 TKNTQNFKPAPATNTQNY------------ATYRE-------GYN 879

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.