DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIB and Gria1

DIOPT Version :9

Sequence 1:NP_523485.3 Gene:GluRIIB / 33789 FlyBaseID:FBgn0020429 Length:913 Species:Drosophila melanogaster
Sequence 2:NP_113796.1 Gene:Gria1 / 50592 RGDID:621531 Length:907 Species:Rattus norvegicus


Alignment Length:868 Identity:245/868 - (28%)
Similarity:408/868 - (47%) Gaps:92/868 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIF 89
            |:||.:|.:.:.:...||..||.::.  .|...|..|. .|.:.||..:....|.....||.|||
  Rat    25 IQIGGLFPNQQSQEHAAFRFALSQLT--EPPKLLPQID-IVNISDSFEMTYRFCSQFSKGVYAIF 86

  Fly    90 GPSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS 151
            |...:..   |.:|.:..|..|:.|   .:....||      |..:.:.|.   |..|...|:  
  Rat    87 GFYERRT---VNMLTSFCGALHVCFITPSFPVDTSN------QFVLQLRPE---LQEALISII-- 137

  Fly   152 KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNAREKFV 212
            ..:.|::|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.:...:|:.|
  Rat   138 DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEG--YRMLFQDLEKKKERLV 200

  Fly   213 LLDCPSDILVDVINASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGFYSRDFTVAVAAV 267
            ::||.|:.|..::...:.....|...|..|.||   |..|       :.:.||...::|..:.|.
  Rat   201 VVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAR 265

  Fly   268 RIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIP 323
            .::.:......|.     ..||.:.....|.|.||.:.:...|.       ::||:|  .|..:.
  Rat   266 IMQQWRTSDSRDH-----TRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLA 325

  Fly   324 NFSCGRGFWQPGPRLVEQMKQITPKMVKPPFK--TQRLQINADGQREDFNLEVYNPIIDRVTHI- 385
            |.:..   |..|..:...::|:.       |:  |..:|.|..|:|.::.|.|.....|.:..| 
  Rat   326 NPAVP---WGQGIDIQRALQQVR-------FEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380

  Fly   386 -WNKEFQLV----DFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVH 445
             ||::.:.|    |.:...:||:       :||:        .|.|.|.:..||...::...  .
  Rat   381 YWNEDDKFVPAATDAQAGGDNSS-------VQNR--------TYIVTTILEDPYVMLKKNAN--Q 428

  Fly   446 YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDL 510
            :|||:|:|||.|:|...:|:...:.:..|.|.|.|||:.|.:|..|:|::.:|:...|.:.:..|
  Rat   429 FEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPL 493

  Fly   511 TITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTG 575
            |||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|....
  Rat   494 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 558

  Fly   576 RIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFA 637
            |...|||........|:.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::...||.|.
  Rat   559 RFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 623

  Fly   638 LLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKM 702
            |:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|........|..|
  Rat   624 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYM 688

  Fly   703 LSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLN 766
            .|.:|..|.:..|||:.||:.|||.||:|:|:|..:|..||. |:..::|.:...|.||||.|..
  Rat   689 KSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG 753

  Fly   767 ADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD--GQFDMDSVGGLFVVLIVGV 829
            :..|:.:::.:|:|:|:|.|.||:|||: .::..|.|......|  ....:.:|.|:|.:||.|:
  Rat   754 SALRNPVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGL 817

  Fly   830 VVGLVIGVAEFLWHVQRISVKEK 852
            .:.:::.:.||.:..:..|.:.|
  Rat   818 GLAMLVALIEFCYKSRSESKRMK 840

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIBNP_523485.3 PBP1_iGluR_Kainate 26..393 CDD:107377 91/396 (23%)
ANF_receptor 41..378 CDD:279440 84/364 (23%)
PBP2_iGluR_Kainate 422..795 CDD:270432 134/376 (36%)
Lig_chan 555..822 CDD:278489 91/272 (33%)
Gria1NP_113796.1 PBP1_iGluR_AMPA_GluR1 26..392 CDD:380613 92/399 (23%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 135/391 (35%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)