Protein Alignment GluRIIB and grin2da

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_009292354.1
• Gene: grin2da / 449864
• ZFINID: ZDB-GENE-041008-124
• Length: 1916
• Species: Danio rerio
• Alignment Length: 980
• Identity: 208/980 - (21%)
• Similarity: 390/980 - (39%)
• Gaps: 208/980 - (21%)

  Fly    16 SGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDD----SIVLQDI 76
            |||...:.....|..|      |:.|:|..:.| :.:.|....:.|  ::.|::    |::||
Zfish    76 SGAGPSSSSGSSGTAF------LSRAWSGQVGE-SVMTPWGPANVI--WLAVNESSPGSLLLQ-- 129

  Fly    77 SCDLIGS----GVAAIF------GPSSKTNSDIVEVLCNMTGIPHLQ------FDWHPQQSNRER 125
            .|:|:.:    |:  :|      .|:....:.::|.:...||:|.:.      ....||:|....
Zfish   130 LCELLATTPLQGL--VFEEEKPPPPNRAPLAPMLEFVSAQTGVPVIAVGGGAGLGREPQESGSVY 192

  Fly   126 MNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYER----SSHLIRLQ-----HILAWKQL 181
            :....:.     :|.|...| ::|  :.|||.:|::...|    ...|..::     ..:.|::.
Zfish   193 LQFSCST-----DLQLEVIF-EVL--EEFDWTAFSVVTTRHHGYEDFLAMVEGMIDGSFIGWERK 249

  Fly   182 HKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLD 246
            ....:.:.:...|...|.|.|. |.|:.:  ||.|..:....:..|:.........:..|...
Zfish   250 SVVMLNLTDDPGGARTRRLLKE-NEAQVR--LLYCSQEEAEQIFKAAWASGQATPSHMWFAVG-- 309

  Fly   247 THLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL 311
               .|:.|........|:.|||     |....||       ...|.:...|.|.:.::.|
Zfish   310 ---PGLSGLGLEGLPKALFAVR-----PQGWRDE-------PRRRIAKGVSVLTHGAMAL----- 354

  Fly   312 LEISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRL--------QINADGQRE 368
                :|      .:...||....|..:::..            :|||:        .|...|:..
Zfish   355 ----RR------EYGGARGTSFAGNCMMDGN------------QTQRVPGRIRFFSNITLSGRDY 397

  Fly   369 DFNLEVY--NPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPI----RYTVA 427
            .||.:.|  ||::|.:::...:.::.|.:   .||....|:.........| .||:    ...|.
Zfish   398 SFNNDGYLANPLLDVISYTAGRGWEEVGW---WENGVLRLRYPPWSRYGPF-LKPLDDSQHLRVV 458

  Fly   428 TRVGKPYFSWREEPEG------------------VHYEGNERF----EGYAVDLIYMLAQECKFD 470
            |...:|:........|                  :..||.:..    :|:.:|::..||:...|.
Zfish   459 TLEERPFVIVEPADPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFT 523

  Fly   471 FNFEPVRDNKYGSYDANTD-EWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL 534
            ::...|.:.::|.   |.| :|:|::.:::...|.:.|..|||.:.|..||:|:|||::.|||::
Zfish   524 YDLYLVTNGRHGK---NIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGISVM 585

  Fly   535 ---SYKEPPPKADIYAFLNPYNAEVW--LFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREME 594
               |.....|.    |||.||:..||  :|||...::.....||       |:..|| ..||.::
Zfish   586 VSRSNGTVSPS----AFLEPYSPAVWVMMFVMCLSVVAVTVFIF-------EFFSPV-GYNRSLQ 638

  Fly   595 RQNI-----WHLSNALWLVLGSMLNQGCDL-LPRGLPMRLLTAFWWIFALLISQTYIAKLAAFIT 653
            ....     :.:..::||:...:.|....: .|||...:::...|..||::...:|.|.||||:.
Zfish   639 SGKTAGGSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMI 703

  Fly   654 SSKIAGDIGSLHDLVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTK 712
            ..:....:..|.|...|:      .::|||:..|:|     |.|...|....::.:       .:
Zfish   704 QEEYIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGST-----EENIRSNYPNMHQYM-------VR 756

  Fly   713 NNEEGV----DRVKLSKGTYAFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGIAVPLNADF 769
            ||:.||    :.:|..| ..||:.:...|.|..:::  |::..||..  |....||:|:..|:.:
Zfish   757 NNQRGVEDAIENLKTGK-LDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRW 820

  Fly   770 RSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLV 834
            :..|.:.:|:|....|:..|...|.:   ..|.::...:...:.|:|::.|:|.:|:|.:.:.|:
Zfish   821 KRPLDLALLQLVGDDEIDMLERLWLS---GICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLL 882

  Fly   835 IGVAEFLW-HVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTG--YSSLEQI 896
            :    |.| |:    |..|:...|.......|::.|   .:.:::.....|.|:.|  .|:|.|.
Zfish   883 V----FAWEHL----VYWKLRHCLGRTRGLDFLLAF---SRGMYSCCNFEDETAPGGSQSTLPQY 936

  Fly   897 TSASS 901
            ...|:
Zfish   937 HHVST 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	74/405 (18%)
		ANF_receptor	41..378	CDD:279440	69/375 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	101/424 (24%)
		Lig_chan	555..822	CDD:278489	66/288 (23%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	81/435 (19%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	102/429 (24%)
		HisJ	<507..>590	CDD:223904	26/85 (31%)
		Lig_chan	605..877	CDD:278489	69/295 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830