DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and grid2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	915	Identity:	213/915 - (23%)
Similarity:	377/915 - (41%)	Gaps:	181/915 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVT-VDDSIVLQDI--SCDLIGSGV 85
            :|.|||||.::..|..:.|..|:.::|..|..|:.:.|...|. ||.:...|.:  :|:|:..|:
Zfish    26 IIHIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEFVDGNNPFQAVQEACELMNRGI 90

  Fly    86 AAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNR-------ERMNHQLTVNVAPMELFLSA 143
            .|:.......::..::.|.:...||||.....|..:.|       .......|:.|.| .::|:.
Zfish    91 LALVSSIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPPTTRAQPDDYTLFVRP-PVYLND 154

  Fly   144 AFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAR 208
            ....::...|  |:.|.|.|:                              .||.|  :.|.|
Zfish   155 VIFQVVMEYT--WQKFIIFYD------------------------------TDYDI--RGIEN-- 183

  Fly   209 EKFVLLDCPS----DILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRI 269
                .||..|    |:.:..:.::|...:||.|..:.:..|..:...:     |...:.::....
Zfish   184 ----FLDQTSQQGMDVSLQKVESNINMMITGMFRTMRVEELHRYRDTL-----RRAVLFMSPATA 239

  Fly   270 RTYVPPPVHDEIDVFD----------NSVDTR---FSSLG------------------------- 296
            :.::...|...:..||          :.:|.:   ..|:|
Zfish   240 KAFITEVVETNLVAFDCQWIIINEEISDMDVQELVMKSIGRLTLVRQTFPLPQNTSQRCVRNNHR 304

  Fly   297 -------------------SQLVYDSIVLFYNAL-LEISQRPGFYIPNFSC---GRGFWQPGPRL 338
                               ::.:||:::|..|.. .::..|....:.:.||   |...||.|..:
Zfish   305 INTSLCDPKDPKAQMLEITNRYIYDTVLLLANTFHRKLEDRKWHSMASLSCIRKGSKPWQGGKSM 369

  Fly   339 VEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVY--NPIIDR---VTHI--WNKEFQLVDFE 396
            :|.:|:.....:     |..|:.|.:|...:.:.|:.  |...||   |:.:  |:....|
Zfish   370 LETVKKGGVSGL-----TSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLATWDPIHGL---- 425

  Fly   397 KLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIY 461
                |.|  |..::|:|    :.:.:...|.|.:.:|:....|...|    ..::::|:::|::.
Zfish   426 ----NGT--LTDRKLEN----NMRGVVLRVVTVLEEPFVMVSENVLG----KPKKYQGFSIDVLD 476

  Fly   462 MLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPF 526
            .||....|.:......|:||||..|: ..|:|:|.:|:...|.:|:..||||..|.||||||..:
Zfish   477 ALANYLGFKYEIYVAPDHKYGSQQAD-GTWNGLIGELVFKRADVGLSALTITPERESVVDFTTRY 540

  Fly   527 MQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNR 591
            |...:.:| .::.....|::|.|.|::..:|..:...:::.. .|::.     ..|..|   ...
Zfish   541 MDYSVGVL-LRKAERTVDMFACLAPFDLSLWACIAGTVLLVG-TLVYL-----LNWLNP---PRL 595

  Fly   592 EMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSK 656
            .|...:...|.|::|.|.||.:.||.::....|..|::...||:|||::..:|.|.||||:|.|:
Zfish   596 PMGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISR 660

  Fly   657 IAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLS-----FKPDAFTKNN-- 714
            |...|.||.||..|..:.:||:...|  ||....:...|....:.|.|     .......:||
Zfish   661 IENSIQSLQDLAKQTDLPYGTVLDSA--VYDQVRSKGMNPFERDPMYSQMWRMINRTGGAENNVE 723

  Fly   715 --EEGVDRVKLSKGTYAFLMETTNLQYYV--QRNCELTQIGESFGEKHYGIAVPLNADFRSNLSV 775
              :||:.:||.  |.:||:.:...|:|..  ..:|.|..:..:..::.||:|:...:.:|...|.
Zfish   724 ESKEGIRKVKY--GRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQ 786

  Fly   776 GILRLSERGELFKLRNKWFNSNESTCD--SNVPTIDDGQ-FDMDSVGGLFVVLIVGVVVGLVIGV 837
            .||.|.:.|::..|:.||: ..:|.||  |.|.|...|. .|:.|..|:|.||..|||:..:|..
Zfish   787 RILELQQNGDMDILKLKWW-PRDSPCDLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVLSCLIAT 850

  Fly   838 AEFLW 842
            .|..|
Zfish   851 VETWW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	80/448 (18%)
		ANF_receptor	41..378	CDD:279440	70/413 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	107/383 (28%)
		Lig_chan	555..822	CDD:278489	78/280 (28%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	81/457 (18%)
		ANF_receptor	42..404	CDD:279440	69/412 (17%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	107/385 (28%)
		Lig_chan	568..841	CDD:278489	81/286 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740