Protein Alignment GluRIIB and GluRIB

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1030
• Identity: 245/1030 - (23%)
• Similarity: 417/1030 - (40%)
• Gaps: 260/1030 - (25%)

  Fly     6 FLVLLALAIASGANED---------TLVIKIGAIFFDTEMKLADAFSAAL--EEVNAINPALKLD 59
            ||:.|..:...|....         |..|.:||||.....::..||..|:  ..:|..:...:|.
  Fly    14 FLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQ 78

  Fly    60 AIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRE 124
            |....:...|:..|..:.|:....||.::.|..|..:.|.:....|...:|.:. .|.|::.
  Fly    79 AYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT-PWFPEKV--- 139

  Fly   125 RMNHQLTVNVAPMELFLSAAFS----------DILASKTFDWKSFTIAYERSSHLIRLQHILAWK 179
                     :.|...||..|.|          |.:  :.:.|:.....|:....|:|||.|
  Fly   140 ---------LTPSSGFLDFALSMRPDYHQAIIDTI--QFYGWRKIIYLYDSHDGLLRLQQI---- 189

  Fly   180 QLHKAGIKMQEFERGDD-YRI-LWKRINNA----------------REKFVLLDCPSDILVDVIN 226
                    .|....|:: ::: |.|||:|.                ..|.::||||:::...::.
  Fly   190 --------YQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILI 246

  Fly   227 ASIGYNMTGSFNHLFLTNLDTHLSGI---DGFYSRDFTVAVAAVRIRTYVPPPVHDEI--DVFDN 286
            ..:.....|...:.:|      |||:   |.:.|.  .:...|:.|..:.....:..:  :.:|:
  Fly   247 QHVRDLRLGRRTYHYL------LSGLVMDDRWESE--IIEFGAINITGFRIVDTNRRLVREFYDS 303

  Fly   287 --------SVDTRFSSLGSQ--LVYDSIVLFYNALLEISQR------------------------ 317
                    ||.....|:.:|  |:||::.:...|..:|.::
  Fly   304 WKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAAS 368

  Fly   318 ---PGFYIPNFS----------CGRGF---------------------------WQPGPRLVEQM 342
               .|:   |:|          .|.||                           |:.|.::...:
  Fly   369 TSSDGY---NYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYL 430

  Fly   343 KQITPKMVKPPFKTQRLQINADGQREDFNLEV----YNPIIDRVTHIWNKEFQLVDFEKLRENST 403
            :::..:.:     |..::.|.||:|.::.|.|    .|..:.:|.. ||.:..|
  Fly   431 RKVEIEGL-----TGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAE-WNDDAGL----------- 478

  Fly   404 QALKQK--RLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQE 466
            |.|..|  ||:...:| :|...|.|.|.:.:||...::...|....||.|||||..||..:||:|
  Fly   479 QPLNAKYVRLRPHVEF-EKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKE 542

  Fly   467 CKFDFNFEPVRDNKYGSYDANT-DEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLG 530
            ...::....|:|..|||..::. ..|||::.:|:...|.|.|..:|||..|..|:||:.|||.||
  Fly   543 LGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLG 607

  Fly   531 ISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW----DQPVEN--- 588
            |||:..|.......:::|:||.:.|:|:.|:.:.:..:..|.|..|...:||    .||.::
  Fly   608 ISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSP 672

  Fly   589 ---------VNRE------------------------------------------------MERQ 596
                     .|::                                                :...
  Fly   673 DPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEF 737

  Fly   597 NIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDI 661
            ::|   |:.|..|.:.:.|||||.||.:..|:..|.|:.|.|::..:|.|.||||:|..::...|
  Fly   738 SVW---NSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPI 799

  Fly   662 GSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKG 726
            .|..||..|.:||:||:..|:|..:|..|....:...|..|.|.| ..|....:||:.||:.|||
  Fly   800 NSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKG 863

  Fly   727 TYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLR 790
            .||.|:|:...:|...|. |:..::|.:...|.:|||.||.:..:..:::.:|.|.|.|||.|||
  Fly   864 KYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLR 928

  Fly   791 NKWFNSNESTCDSNVPTIDDG-----QFDMDSVGGLFVVLIVGVVVGLVIGVAEF 840
            |||: ..::.|.    |..||     :..:.:|.|:|.:||.|::|.:.:.:.|:
  Fly   929 NKWW-YEKAECS----THKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEY 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	85/479 (18%)
		ANF_receptor	41..378	CDD:279440	78/449 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	134/438 (31%)
		Lig_chan	555..822	CDD:278489	91/336 (27%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	85/478 (18%)
		ANF_receptor	55..461	CDD:279440	77/448 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	134/445 (30%)
		Lig_chan	632..967	CDD:278489	94/343 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462508
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840