DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GluRIID

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	968	Identity:	267/968 - (27%)
Similarity:	466/968 - (48%)	Gaps:	155/968 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLALA-------------IASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKL 58
            |::|:|:             .:||.:     |::|.|..|...::...|..|:..||. ...:.|
  Fly     8 LIILSLSRVQAQFYGGNAYEASSGQS-----IRLGLITDDATDRIRQTFEHAISVVNN-ELGVPL 66

  Fly    59 DAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGI----PHLQFDWHPQ 119
            ......|...:|:......|.|:.|||.|:|||:::..:..:...|:...|    |||.:..:|.
  Fly    67 VGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPD 131

  Fly   120 QSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKA 184
                       ..|:.|....::.|..||:  ..|:|..|...||.:.:|..|.|::....:...
  Fly   132 -----------GFNLHPSPEDIANALYDIV--NQFEWSRFIFCYESAEYLKILDHLMTRYGIKGP 183

  Fly   185 GIKMQEFE--RGDDYRILWKRINNARE-KFVLLDCPSDIL--------VDVINASIGYNMTGSFN 238
            .||:..::  ...:|:.:.:||..:.: :.|::...:.:.        |.::|....|
  Fly   184 VIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTY------- 241

  Fly   239 HLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVP---------PPVHDEIDVFD--NSVDTRF 292
              .:.||:.|...::.:...:..:    ..||.:.|         ..:|.|:...:  ||..| |
  Fly   242 --IIGNLNLHTFDLEEYKYSEANI----TGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGST-F 299

  Fly   293 SSLGSQLVYDSI---------VLFYNALLEISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPK 348
            .::...|.||::         :.:...:|..|:|.....|:.|..|.:.:   .|..:.|.||.:
  Fly   300 ITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMR---SLEIKEKTITGR 361

  Fly   349 M-----VKPPFKTQRLQINADG--------QREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRE 400
            :     |:..|....:::...|        :.:||..:              :..|.|:|..:.:
  Fly   362 IYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQ--------------RPPQAVNFNDIDD 412

  Fly   401 NSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQ 465
            .|        |.||...    :..:|||   |||.|..|..:.:  .||.:|:||.||||..||.
  Fly   413 GS--------LVNKTFI----VLISVAT---KPYASLVESIDTL--IGNNQFQGYGVDLIKELAD 460

  Fly   466 ECKFDFNFEPVRD--NKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQ 528
            :..|:|.|   ||  |.|||::..|:...|:::::::..|.:.|.|||||..|..|:||::|||.
  Fly   461 KLGFNFTF---RDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMN 522

  Fly   529 LGISILSYKEPPPKAD--IYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNR 591
            |||:||..|  |.||.  :::|::|:::||||::.||.:..:......||:...|||.|...:..
  Fly   523 LGIAILYVK--PQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEE 585

  Fly   592 EMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSK 656
            ..|.:|.:.::|:||...|::|.||.::.|:.|..|.::|.||.|.|::..:|.|.||||:|...
  Fly   586 PEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIEN 650

  Fly   657 IAGDIGSLHDLVD-QNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDR 720
            ....|.|:.||.| ::.||:|..|.|:|..:||.|.: ...:..|:.|:..|:...:||::|||:
  Fly   651 PTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEE-PIYIKMNEYLNAHPEMLMENNQQGVDK 714

  Fly   721 VKLSKGT-YAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERG 784
            ||  .|| ||||||:|::::...|.|.||::|:...||.||||:..|..:|...:..:|.|.|:|
  Fly   715 VK--SGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777

  Fly   785 ELFKLRNKWFNS-NESTCDSNVPTIDDG--QFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQR 846
            .|.:|:|||:|. ....|.:.  :.|||  :..:|::.|::|||::|.::.::|.:..:.:.|.:
  Fly   778 VLARLKNKWWNEVGAGVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYK 840

  Fly   847 ISVKEKIPPMLALKAEFYFVIRFWLTRKPLHT----YRQSRDSTSTGYSSLEQITSAS 900
            .:...::|...||..||..||||....:||.:    |.:||:|:    .|:|.:.:.|
  Fly   841 KAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSS----QSIESLKTDS 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	78/414 (19%)
		ANF_receptor	41..378	CDD:279440	74/384 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	146/378 (39%)
		Lig_chan	555..822	CDD:278489	98/271 (36%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	76/392 (19%)
		ANF_receptor	46..380	CDD:279440	71/364 (20%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	148/387 (38%)
		Lig_chan	549..819	CDD:278489	99/274 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462595
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900