DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and KaiR1D

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	292/883 - (33%)
Similarity:	471/883 - (53%)	Gaps:	64/883 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GLQFLVLLALAIASGANE-DTL--VIKIGAIFFDTEMKLADAFSAALEEVNA---INPALKLDAI 61
            |:..|.||.|.:.....: .:|  :||||.:|...:.....||..|::.:||   |.|..||.|.
  Fly     5 GVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQ 69

  Fly    62 KRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERM 126
            ...::..||.......|.|:..||||||||.|...:..|:.:|:...||||:..| ..:..||
  Fly    70 IERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRW-DYRLRRE-- 131

  Fly   127 NHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEF 191
              ...||:.|....||.|:.||:  :.:.||:|||.||.:..::|||.:|....:....|.:::.
  Fly   132 --SCLVNLYPHPNTLSKAYVDIV--RHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL 192

  Fly   192 ERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFY 256
            ....|||.|.|:|.|:.|..::|||.::.:.:|:..:....|...::...:|:||.|...:|.|
  Fly   193 SDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEF- 256

  Fly   257 SRDFTVAVAAVRIRTYVPPPVHDEI--DVFDN-SVDTR-------FSSLGSQ--LVYDSIVLFYN 309
             |.....:...|:       ::::|  ||... |:|.:       .:::.|:  |:||::.||..
  Fly   257 -RYGGTNITGFRL-------INEKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAK 313

  Fly   310 ALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLE 373
            ||.::.......|...|| |:..||.|..|:..||.:..|.:     |..::.:..|.|.||.|:
  Fly   314 ALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGL-----TNVIKFDHQGFRTDFMLD 373

  Fly   374 V--YNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFS 436
            :  ..|...|....||.  .|.|    ..|.|:...||:.:.:.:...|.:  .|.|.:..||..
  Fly   374 IVELTPAGIRKIGTWNS--TLPD----GINFTRTFSQKQQEIEANLKNKTL--VVTTILSNPYCM 430

  Fly   437 WREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDN 501
            .:|  ..:...||::|||||||||:.:::...|::..:.|.|..|||.:..|.||:|:||:|::.
  Fly   431 RKE--SAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQ 493

  Fly   502 NAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEP---PPKADIYAFLNPYNAEVWLFVMIA 563
            .|.:.|.|||||..|...||||.|||.||:||| |::|   ||  ::::||:|.:.:||:::..|
  Fly   494 RADLAIADLTITFEREQAVDFTTPFMNLGVSIL-YRKPIKQPP--NLFSFLSPLSLDVWIYMATA 555

  Fly   564 MMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRL 628
            .:..:..|....:...|||....:....::|.|  :.|.|.:|..:||::.||||.||:.|..|:
  Fly   556 YLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQ--FTLLNCMWFAIGSLMQQGCDFLPKALSTRM 618

  Fly   629 LTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDT 693
            :...||.|.|::..:|.|.||||:|..::...|.|..||..|.::::|.::||:|:.:|.:|..:
  Fly   619 VAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKIS 683

  Fly   694 DNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKH 758
            ..:..|:.|.|.:|..||.:|.|||:||...||:||||||:|:::|..:|||||||:|.....|.
  Fly   684 TYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKS 748

  Fly   759 YGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD----GQFDMDSVG 819
            ||||.|.|:.:|:.::..||:|.|.|:|..|:.||:..........|.|...    .:..:.:||
  Fly   749 YGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVG 813

  Fly   820 GLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPML 857
            |:||||:.|:.|..||.|.||:|..::::|:|::..:|
  Fly   814 GVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERLSAIL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	111/384 (29%)
		ANF_receptor	41..378	CDD:279440	103/354 (29%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	147/375 (39%)
		Lig_chan	555..822	CDD:278489	96/270 (36%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	113/392 (29%)
		ANF_receptor	42..378	CDD:279440	103/356 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	148/378 (39%)
		Lig_chan	547..823	CDD:278489	100/277 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920