Protein Alignment GluRIIB and Nmdar1

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 973
• Identity: 200/973 - (20%)
• Similarity: 382/973 - (39%)
• Gaps: 237/973 - (24%)

  Fly     1 MHGLQFLVLLA---LAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIK 62
            :.||..::|:|   .|....|:::.....||.:..:::.:  :.||..::.:|     .....:.
  Fly    12 LFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSE--EHFSTTIKHLN-----FDQQYVP 69

  Fly    63 RYVTVDDSIVLQDIS--------CD-LIGSGVAAIFGPSSKTNSDIVEVLCNMT----GIPHLQF 114
            |.||..|..:..|.:        || ||.:.|.|:.....:|:.|:.....:.|    .||.:..
  Fly    70 RKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGI 134

  Fly   115 DWHPQQSNRERMNHQLTVNVAP--------MELFLSAAFSD--ILASKTFDWKSFTIAYERSSHL 169
            .......:.:.::......|.|        :|:....|::.  |:.|...|.::....::.:|..
  Fly   135 SSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQT 199

  Fly   170 ------IR--LQHILAWKQLHKAGIKMQEF-ERGDDYRILWKRINNAREKFVLLDCPSDILVDVI 225
                  :|  ::.|:.::.      |::.| |...|.:....|:      :::.....|  ..||
  Fly   200 YYDDVDVRATVELIVEFEP------KLESFTEHLIDMKTAQSRV------YLMYASTED--AQVI 250

  Fly   226 NASIG-YNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVD 289
            ....| |||||. .|:::..                                   |..:|.|  :
  Fly   251 FRDAGEYNMTGE-GHVWIVT-----------------------------------EQALFSN--N 277

  Fly   290 TRFSSLGSQL---------VYDSIVLFYNALLE------ISQRPGFYIPNFSCGRGF--WQPGPR 337
            |....||.||         :.||:.:..:|:.|      |::.|.      .||...  |:.|.|
  Fly   278 TPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPK------DCGDSAVNWESGKR 336

  Fly   338 LVEQMK--QITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRE 400
            |.:.:|  .||.       :|.::..:.:|.|.....:|.|                     :||
  Fly   337 LFQYLKSRNITG-------ETGQVAFDDNGDRIYAGYDVIN---------------------IRE 373

  Fly   401 NSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSW----REEPEGV----HYE---------- 447
            .     ::|.:..|  ||...:|..:..|:......|    |.:|||:    |..
  Fly   374 Q-----QKKHVVGK--FSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFV 431

  Fly   448 -----GNERF------------------------EGYAVDLIYMLAQECKFDFNFEPVRDNKYGS 483
                 |::.|                        .||.:||:..|::...|.::.....|.::|.
  Fly   432 YVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGH 496

  Fly   484 YDANTD--------EWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPP 540
            |....:        ||.|:|.:|::..|.:.:..|||...|...::|:.||...||:||. |:|.
  Fly   497 YILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILE-KKPS 560

  Fly   541 PKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNAL 605
            ..:.:.:||.|::..:|:.||:::.:.|..|....|...:...:...:.:.|.:..|   ||:|:
  Fly   561 RSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALN---LSSAV 622

  Fly   606 WLVLGSMLNQGC-DLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVD 669
            |...|.:||.|. :..||....|:|...|..||::|..:|.|.||||:...:....:..::|...
  Fly   623 WFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARL 687

  Fly   670 QNKVQ---FGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNN----EEGVDRVKLSKGT 727
            :|.::   ..|::|.:..:||....:..|...          ....||    |:.:..||..| .
  Fly   688 RNTMENLTCATVKGSSVDMYFRRQVELSNMYR----------TMEANNYATAEQAIQDVKKGK-L 741

  Fly   728 YAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNK 792
            .||:.:::.|:|...::|||...||.||...|||.:...:.:...:::.||...|.|.:.||..:
  Fly   742 MAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQ 806

  Fly   793 W-FNSN-ESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853
            | |:.: :..|:....|  .....:.::.|:|:::.||:..|:.:.:.|.::...::..::::
  Fly   807 WIFHGHVQQNCELFEKT--PNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRL 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	74/412 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	105/436 (24%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	83/467 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	99/415 (24%)
		CaM_bdg_C0	854..882	CDD:402271	0/14 (0%)