DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Nmdar1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	973	Identity:	200/973 - (20%)
Similarity:	382/973 - (39%)	Gaps:	237/973 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHGLQFLVLLA---LAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIK 62
            :.||..::|:|   .|....|:::.....||.:..:::.:  :.||..::.:|     .....:.
  Fly    12 LFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSE--EHFSTTIKHLN-----FDQQYVP 69

  Fly    63 RYVTVDDSIVLQDIS--------CD-LIGSGVAAIFGPSSKTNSDIVEVLCNMT----GIPHLQF 114
            |.||..|..:..|.:        || ||.:.|.|:.....:|:.|:.....:.|    .||.:..
  Fly    70 RKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGI 134

  Fly   115 DWHPQQSNRERMNHQLTVNVAP--------MELFLSAAFSD--ILASKTFDWKSFTIAYERSSHL 169
            .......:.:.::......|.|        :|:....|::.  |:.|...|.::....::.:|..
  Fly   135 SSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQT 199

  Fly   170 ------IR--LQHILAWKQLHKAGIKMQEF-ERGDDYRILWKRINNAREKFVLLDCPSDILVDVI 225
                  :|  ::.|:.::.      |::.| |...|.:....|:      :::.....|  ..||
  Fly   200 YYDDVDVRATVELIVEFEP------KLESFTEHLIDMKTAQSRV------YLMYASTED--AQVI 250

  Fly   226 NASIG-YNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVD 289
            ....| |||||. .|:::..                                   |..:|.|  :
  Fly   251 FRDAGEYNMTGE-GHVWIVT-----------------------------------EQALFSN--N 277

  Fly   290 TRFSSLGSQL---------VYDSIVLFYNALLE------ISQRPGFYIPNFSCGRGF--WQPGPR 337
            |....||.||         :.||:.:..:|:.|      |::.|.      .||...  |:.|.|
  Fly   278 TPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPK------DCGDSAVNWESGKR 336

  Fly   338 LVEQMK--QITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRE 400
            |.:.:|  .||.       :|.::..:.:|.|.....:|.|                     :||
  Fly   337 LFQYLKSRNITG-------ETGQVAFDDNGDRIYAGYDVIN---------------------IRE 373

  Fly   401 NSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSW----REEPEGV----HYE---------- 447
            .     ::|.:..|  ||...:|..:..|:......|    |.:|||:    |..
  Fly   374 Q-----QKKHVVGK--FSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFV 431

  Fly   448 -----GNERF------------------------EGYAVDLIYMLAQECKFDFNFEPVRDNKYGS 483
                 |::.|                        .||.:||:..|::...|.::.....|.::|.
  Fly   432 YVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGH 496

  Fly   484 YDANTD--------EWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPP 540
            |....:        ||.|:|.:|::..|.:.:..|||...|...::|:.||...||:||. |:|.
  Fly   497 YILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILE-KKPS 560

  Fly   541 PKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNAL 605
            ..:.:.:||.|::..:|:.||:::.:.|..|....|...:...:...:.:.|.:..|   ||:|:
  Fly   561 RSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALN---LSSAV 622

  Fly   606 WLVLGSMLNQGC-DLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVD 669
            |...|.:||.|. :..||....|:|...|..||::|..:|.|.||||:...:....:..::|...
  Fly   623 WFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARL 687

  Fly   670 QNKVQ---FGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNN----EEGVDRVKLSKGT 727
            :|.::   ..|::|.:..:||....:..|...          ....||    |:.:..||..| .
  Fly   688 RNTMENLTCATVKGSSVDMYFRRQVELSNMYR----------TMEANNYATAEQAIQDVKKGK-L 741

  Fly   728 YAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNK 792
            .||:.:::.|:|...::|||...||.||...|||.:...:.:...:::.||...|.|.:.||..:
  Fly   742 MAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQ 806

  Fly   793 W-FNSN-ESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853
            | |:.: :..|:....|  .....:.::.|:|:::.||:..|:.:.:.|.::...::..::::
  Fly   807 WIFHGHVQQNCELFEKT--PNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRL 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	74/418 (18%)
		ANF_receptor	41..378	CDD:279440	72/388 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	105/436 (24%)
		Lig_chan	555..822	CDD:278489	68/276 (25%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	89/492 (18%)
		ANF_receptor	58..371	CDD:279440	70/403 (17%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	99/415 (24%)
		HisJ	451..>558	CDD:223904	26/107 (24%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	39/138 (28%)
		Lig_chan	575..838	CDD:278489	69/278 (25%)
		CaM_bdg_C0	854..882	CDD:287524	0/14 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462671
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940