DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Ir75d

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	156/821 - (19%)
Similarity:	278/821 - (33%)	Gaps:	253/821 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 MTGIPHLQFDWHPQQSNRE-----RMNHQLTVNVAPM-------ELFLSAAFSDILASKT----- 153
            ::|.|.:...|..:.|.::     |..:||...:...       .|.|....:||...:.
  Fly    17 VSGTPRVAGSWRSEYSRQDPDPKTRWGNQLPDMLVAYYRHHGVHSLMLVVCHTDIADFRLWKLWQ 81

  Fly   154 -FDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCP 217
             |:..:|.:.....|.|..|||:.|..: ||.....:.|...:...  |:      ..|:|...|
  Fly    82 HFNLNNFYVQVSTESSLRDLQHVDALDE-HKDAPPPKSFHANNSTH--WE------TSFLLPALP 137

  Fly   218 --SDILVDVINASIGYNM----TGSFNHLFLTN-----LDTHLSGIDGFYSRDFTVAVAAVRIRT 271
              ..||:...::....|:    ..|.::.|.||     |......||.....:.
  Fly   138 YKMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLEDPEI----------- 191

  Fly   272 YVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGFWQPGP 336
            ::||  ..|:.|               |.|::                  :.||||.
  Fly   192 FIPP--DSELRV---------------LHYEN------------------VGNFSCS-------- 213

  Fly   337 RLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLREN 401
             |::..|....|    |.|...:..|....|.         :|..:.|..:......|.|.:..|
  Fly   214 -LIDLYKVAAWK----PLKRTLVGHNIRNSRH---------VIHALQHFGSAITYRQDLEGIVFN 264

  Fly   402 STQALKQKRL-QNKEDFSQKPI----------RYTVATRVGKPY-------FSWREEPEGVHYEG 448
            |...:....| .|.||.|.:.|          ...:|.|:...|       :.|| :|.| .::|
  Fly   265 SAIVIAFPDLFTNIEDLSLRHIDTISKVNHRLMLELANRLNMSYNTYQTVNYGWR-QPNG-SFDG 327

  Fly   449 -NERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTI 512
             ..||:.|.:||                                           ||:.|   .:
  Fly   328 LMGRFQRYELDL-------------------------------------------AQLAI---FM 346

  Fly   513 TQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRI 577
            ...|.::|||.....::...|: :::||..|....|..|:..:||:.:::.::||...|:.....
  Fly   347 RLDRIALVDFVAETYRVRAGIM-FRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLELFF 410

  Fly   578 DQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQ 642
            ..:         |.:|...:   ..|.:|   |:|..||..:..|....|::....::.||.:..
  Fly   411 SPH---------NHDMSYMD---TLNFVW---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFT 460

  Fly   643 TYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKP 707
            ::.|.:.|.:.|...|  |.||.|| .|:.::.|........:||:||.|...:..::|.::.|.
  Fly   461 SFSANIVALLQSPSDA--IQSLSDL-GQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKG 522

  Fly   708 DAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGE-KHYG----------- 760
            :........|::  |:..|.:|:.:|       :|...::  :.::|.| :..|
  Fly   523 ENIYMRPLLGME--KMRTGLFAYQVE-------LQAGYQI--VSDTFSEPEKCGLMELEPFQLPM 576

  Fly   761 IAVPLNADF----------RSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDM 815
            :|:|...:|          |....|.::...||        ||....        |..:.|....
  Fly   577 LAIPTRKNFPYKELIRRQLRWQREVSLVNREER--------KWIPQK--------PKCEGGVGGF 625

  Fly   816 DSVG--------GLFVVLIVGVVVGLVIGVAEFLW-HVQRI 847
            .|:|        |:|.   .|..|..|:.:.||:: |.:::
  Fly   626 VSIGITECRYALGIFG---CGAAVSFVLFLFEFIFRHFKQV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	55/315 (17%)
		ANF_receptor	41..378	CDD:279440	53/300 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	80/412 (19%)
		Lig_chan	555..822	CDD:278489	58/296 (20%)
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	50/249 (20%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	59/303 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840