DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Ir68a

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	117/572 - (20%)
Similarity:	209/572 - (36%)	Gaps:	143/572 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 HIWNKEFQLVDFEKLREN----STQA--------LKQKRLQNKE---------DFSQKP-----I 422
            |:|:.....:..::..:|    ||.|        |..|.:.|.|         .|:.|.     .
  Fly   158 HLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVMKNIANWELGKGLNGRILFADKTSNLFGT 222

  Fly   423 RYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPV--RDNK----- 480
            ...||.....|...|.        ...:.|:|..|:::..|.:.    .||:||  :.|:
  Fly   223 SLPVAISEHVPMVLWA--------NATKSFQGVEVEIMNALGKA----LNFKPVYYKPNQTENMD 275

  Fly   481 -----------YGS-----YDANTDEWDG-IIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQ 528
                       |||     |..|....|. ::.::..::|:..|.||.:.|....:|:.:.|.
  Fly   276 WTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPH-- 338

  Fly   529 LGISILSYKEPPPKAD--IYAFLNPYNAEVWLFVMIAMMITA---FALIFTGRI-------DQYE 581
             ....|::..|....|  ...|:.|::|.:|:.|::::.:..   :|:.|...|       :.:.
  Fly   339 -NFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFR 402

  Fly   582 WDQPVENVNRE-----------------------MERQNIWHLSNALWLVLGSMLNQGCDLLPRG 623
            ..:|..||..:                       |.|......:|.:.|....:|......:||.
  Fly   403 CLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALPRMPRN 467

  Fly   624 LPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATS--VY 686
            .|:|:||.::||:.:|:..||.|...|.:.:......|.:|.||: ::.:...|   |||.  .:
  Fly   468 WPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLL-RSHIPPST---GATENRQF 528

  Fly   687 FSESNDTDNRMAWNKMLSF-KPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQY----------- 739
            |.|:||...|....||..| ..|..|.         :::||..|:......|:|
  Fly   529 FLEANDEVARKVGEKMEVFGYSDDLTS---------RIAKGQCAYYDNEFYLRYLRVADESGSAL 584

  Fly   740 YVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSN 804
            ::.:.|.|..        ...:|:..|:..:..:...|..|:|.|    |..||.........:.
  Fly   585 HIMKECVLYM--------PVVLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAE 637

  Fly   805 VPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPM 856
            .....:...::......||.|::|.|:.::..:|| .||.:.|.:|.   ||
  Fly   638 ALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAE-RWHFKHIVMKH---PM 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	2/8 (25%)
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	92/445 (21%)
		Lig_chan	555..822	CDD:278489	60/313 (19%)
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	55/256 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740