Protein Alignment GluRIIB and GluRIA

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 1042
• Identity: 249/1042 - (23%)
• Similarity: 432/1042 - (41%)
• Gaps: 213/1042 - (20%)

  Fly     1 MHG-LQFLVLLALAIA--------SGANED------TLVIKIGAIFFDTEMKLADAFSAAL--EE 48
            ||. |:||..|....|        |.|.:.      |..|.:||||......:..||..|:  ..
  Fly     1 MHSRLKFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHN 65

  Fly    49 VNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQ 113
            :|..:...:|.|....:...|:..|..:.|:....||.::.|..|..:.|.:....|...:|.:.
  Fly    66 LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 130

  Fly   114 FDWHPQQSNRERMNHQLTVNVAPMELFLSAAFS----------DILASKTFDWKSFTIAYERSSH 168
             .|.|::.            :||....|..|.|          |.:  :.:.|:|....|:....
  Fly   131 -PWFPEKV------------LAPSSGLLDFAISMRPDYHQAIIDTI--QYYGWQSIIYLYDSHDG 180

  Fly   169 LIRLQHILAWKQLHKAGIKMQEFERGDD-YRI-LWKRINNA----------------REKFVLLD 215
            |:|||.|            .||.:.|:: :|: :.|||.|.                .:|.::||
  Fly   181 LLRLQQI------------YQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLD 233

  Fly   216 CPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGI--DGFYSRDFTVAVAAVRIRTY------ 272
            ||:::..::|...:.....|...:.:|      |||:  |..:..| .|...|:.|..:
  Fly   234 CPAEMAKEIIVQHVRDIKLGRRTYHYL------LSGLVMDNHWPSD-VVEFGAINITGFRIVDSN 291

  Fly   273 --VPPPVHDEIDVFDNSVDTRFSSLG-----------SQLVYDSIVLFY---------------- 308
              .....||.....:.|..::..:.|           :.|:||::.:..
  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356

  Fly   309 ----------------------NALLEISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVK 351
                                  :|||:.:...|:..|        |:.|.::...:::     |:
  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTP--------WEQGEKISRVLRK-----VE 408

  Fly   352 PPFKTQRLQINADGQREDFNLEV----YNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQ 412
            ....:..::.:.||:|.::.|.|    .|..:.:|.. |..:..|:   .|..::..:..:....
  Fly   409 IDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE-WRDDAGLL---PLHSHNYASSSRSASA 469

  Fly   413 NKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVR 477
            :..|:.:.. .|.|::.:.:||.|.::...|....||:|||||..||..|||.:....:....|:
  Fly   470 STGDYDRNH-TYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQ 533

  Fly   478 DNKYGSYDANT-DEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPP 541
            |..||:.:... ..|||::.:||...|.|.|..:|||..|..|:||:.|||.|||||:..|....
  Fly   534 DGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQ 598

  Fly   542 KADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW------------DQPVENVNRE-- 592
            ...:::||||.:.|:|:.|:::.:..:|.|.|..|...|||            .||...:...
  Fly   599 TPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATL 663

  Fly   593 MERQ--------NIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLA 649
            .|.|        |.:.:.|:.|..|.:.:.||||:.|..:..|:..|.||.|.:::..:|.|.||
  Fly   664 SEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLA 728

  Fly   650 AFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNN 714
            ||:|..::...|.:..||..|..|.:||:..|:|..:|..|....:...|..|.:.:..: ....
  Fly   729 AFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS-VHTY 792

  Fly   715 EEGVDRVKLSKGTYAFLMETTNLQYYVQR-NCELTQIGESFGEKHYGIAVPLNADFRSNLSVGIL 778
            :||:.||:.|||.||.|:|:...:|...| .|:..::|.:...|.:|:|.|:.:..|..|:..:|
  Fly   793 DEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVL 857

  Fly   779 RLSERGELFKLRNK-WFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLW 842
            .|.|.|||.::||| ||:..|  |:.:..|....:..:.:|.|::.:||.|:::.:::.:.||..
  Fly   858 TLKENGELLRIRNKWWFDKTE--CNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFC 920

  Fly   843 HVQRISVKEK--------IPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSA 899
            ..:...:|..        :|.|||..                 ||::...|.:..:|..:....|
  Fly   921 RNKTPQLKSPGSNGSAGGVPGMLASS-----------------TYQRDSLSDAIMHSQAKLAMQA 968

  Fly   900 SS 901
            ||
  Fly   969 SS 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	83/459 (18%)
		ANF_receptor	41..378	CDD:279440	77/429 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	129/397 (32%)
		Lig_chan	555..822	CDD:278489	85/290 (29%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	83/459 (18%)
		ANF_receptor	53..434	CDD:279440	76/427 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	131/405 (32%)
		Lig_chan	612..907	CDD:278489	87/297 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462512
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840