Protein Alignment GluRIIB and GluRIIA

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 932
• Identity: 405/932 - (43%)
• Similarity: 599/932 - (64%)
• Gaps: 62/932 - (6%)

  Fly     6 FLVLLAL---AIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAIN-PALKLDAIKRYVT 66
            |::::..   .||.| .:|...|.:||||::.|.::..:|..|..|||.:. ..|:...||||:.
  Fly    11 FIIIIGFLEGIIALG-GDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP 74

  Fly    67 VDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLT 131
            .:||.:||.|:|:||.:|||||||||||..||||..:.|.|||||:::|...:.:.:|::|||::
  Fly    75 TNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS 139

  Fly   132 VNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEF-ERGD 195
            :||||....||.|:.:|:.| .::|::||:.||....|.|||.::..:.|:...:|::.. :..|
  Fly   140 INVAPSLSVLSRAYFEIIKS-NYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYAD 203

  Fly   196 DYRILWKRINNA-REKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRD 259
            |||||||..:.. .|:.::|||....|.:::..||.:.:.|.|.:.|||:||||.||:...|:.|
  Fly   204 DYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNED 268

  Fly   260 FTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSS----LGSQ-----LVYDSIVLFYNALLEI- 314
            |...:.:||::.....|       |:.. .||.:.    ||:|     |:||::|||.::...:
  Fly   269 FKANITSVRLKVVDANP-------FERK-KTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVI 325

  Fly   315 -SQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNP 377
             :.:| |:.||..||... |..|..:|.:||.|:...|:|.|||:.::::..|||..||||:|.|
  Fly   326 AAMQP-FHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKP 389

  Fly   378 IIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKE--------DFSQKPIRYTVATRVGKPY 434
            .::....:|..:..:               :|||.|.|        |||::...|||.|...:||
  Fly   390 TVNEPMMVWTPDNGI---------------KKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPY 439

  Fly   435 FSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLI 499
            |..:|:.|  ::.|.|::||||||||..|::..:||:.|..|..|  |.|:..|.:||||||:||
  Fly   440 FMMKEDHE--NFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQWDGIIRKLI 500

  Fly   500 DNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAM 564
            |::||||:|||||||.|||||||||||||||||||.||.||...:.:|||.|:..|||::::.|.
  Fly   501 DHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQ 565

  Fly   565 MITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLL 629
            :|...|.:|..|:...||..|...:....|.:|||:::|:.||::||::.||||:||||..||:|
  Fly   566 LIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRIL 630

  Fly   630 TAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTD 694
            |..||.|||::..||.|.||||:||:|....|.||.||::|:||.||::|||:||::||||||||
  Fly   631 TGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTD 695

  Fly   695 NRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHY 759
            .:.|||:|..|.|.|||..|:|||.||:..||.||||||||:|.|.::|||:||||||..|||||
  Fly   696 YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHY 760

  Fly   760 GIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVV 824
            |:||||.:|:|:||||.||:|||||||.|::|||:.::..|||| ...:|..:..:..:||:|:|
  Fly   761 GLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDS-YHEVDGDELSIIELGGVFLV 824

  Fly   825 LIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTG 889
            |..||::|:::|:.||||:||.::|:|::.|..|.|||..|.::||:.:||:. ...|.|.:|:.
  Fly   825 LAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMR-ISSSSDKSSSR 888

  Fly   890 YSSLEQITSASSAKKKKKTRRI 911
            .||    .|..|:|:|.:::.:
  Fly   889 RSS----GSRRSSKEKSRSKTV 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	139/375 (37%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	210/372 (56%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	140/396 (35%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	210/373 (56%)
		Lig_chan	555..828	CDD:459656	145/273 (53%)