DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and gria4b

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	909	Identity:	249/909 - (27%)
Similarity:	414/909 - (45%)	Gaps:	124/909 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QFLVLLAL--AIASGANEDTLVIKIGAIFFDTEMKLADAFSAAL----EEVNAINPALKLDAIKR 63
            |.|:|.:.  .:..||...:  ::||.:|.....:...||..|:    ...||......|.....
Zfish     7 QLLLLFSCVWGLTMGAFPSS--VQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVD 69

  Fly    64 YVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNH 128
            .:...:|..:.:..|.....||.||||...|.:   |..|.:..|..|:........:..|   .
Zfish    70 NIETANSFAVTNAFCSQYSRGVFAIFGLYDKRS---VHTLTSFCGALHISLITPSFPTEGE---S 128

  Fly   129 QLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAG-------- 185
            |..:.:.|.   :..|...:|  ..:||..|...|:.......||.|     :.|||
Zfish   129 QFVLQLRPS---IRGALLSLL--DHYDWNRFVFLYDTDRGYSILQAI-----MEKAGQNGWQVSA 183

  Fly   186 IKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVIN--ASIGYNMTGSFNHLFLTNL--- 245
            |.::.|... .||.|.:.::..:||..::|..::.|.:::.  .|:|.::.|  .|..:.||
Zfish   184 ICVENFNDA-SYRQLLEDLDRRQEKTFVIDLEAERLNNMLEQIVSVGKHVKG--YHYIMANLGFK 245

  Fly   246 DTHL-------SGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-------SSLG 296
            |.:|       :.:.||...||:..:....::.:             |.:|.|.       ....
Zfish   246 DINLERFMHGGANVTGFQLVDFSNPMVIKLMQRW-------------NKLDQREYPGSDAPPKYT 297

  Fly   297 SQLVYDSIVLFYNAL-------LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKP 352
            |.|.||.:::...|.       ::||:|  .|..:.|.:..   |..|..:...:||:..:.:
Zfish   298 SALTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAP---WNQGIDMERTLKQVHLQGL-- 357

  Fly   353 PFKTQRLQINADGQREDFNLEVY-----NPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQ 412
               |..:|.:..|:|.::.::|:     .|   |....||      |.:||......||......
Zfish   358 ---TGNVQFDHYGRRVNYTMDVFELKSNGP---RRIGYWN------DADKLVLTQDHALLPNETS 410

  Fly   413 NKEDFSQKPIRYTVATRVGK-PYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPV 476
            ..|:      |..:.|.:.: ||...::..|  .|||||::|||.|||...:|:...|.:....|
Zfish   411 GMEN------RTVIVTTIMEGPYVMLKKNWE--MYEGNEQYEGYCVDLASEIAKHIGFKYKISIV 467

  Fly   477 RDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPP 541
            .|.|||:.|..|..|:|::.:|:...|:|.:..||||..|..|:||:.|||.|||||:..|....
Zfish   468 PDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 532

  Fly   542 KADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW--DQPVENVNREMERQ--NIWHLS 602
            |..:::||:|...|:|:.::.|.:..:..|....|...|||  ::|.|..:.....|  |.:.:.
Zfish   533 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGTDGLPSDQPPNEFGIF 597

  Fly   603 NALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDL 667
            |:||..||:.:.||||:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||
Zfish   598 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 662

  Fly   668 VDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLM 732
            ..|..:.:||:..|:|..:|..|........|:.|.|.:|..|||...|||.||:.|||.||||:
Zfish   663 AKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLL 727

  Fly   733 ETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNS 796
            |:|..:|..||. |:..::|.:...|.||:|.|..:..||.:::.:|:|:|:|.|.||:|||: .
Zfish   728 ESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWW-Y 791

  Fly   797 NESTCDSNVPTIDDGQFD-------MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853
            ::..|.|.    ..|:.|       :.:|.|:|.:|:.|:.:.:::.:.||.:..:..:.:.|:
Zfish   792 DKGECGSG----GGGEKDKSSQALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRNEAKRMKL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	84/411 (20%)
		ANF_receptor	41..378	CDD:279440	77/381 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	142/378 (38%)
		Lig_chan	555..822	CDD:278489	97/278 (35%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	87/418 (21%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	142/387 (37%)
		Lig_chan	546..827	CDD:306551	99/285 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840