DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GluRIIC

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	370/921 - (40%)
Similarity:	552/921 - (59%)	Gaps:	73/921 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAIN-PALK-----LDAIKRYVTVDDSIVLQDISCDLIGS 83
            |.|||.|:|.|::|...|   :..||||| |..:     ...|||....|.|:.:|:.:||||.:
  Fly    25 INIGAFFYDDELELEKEF---MTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDN 86

  Fly    84 GVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDI 148
            |||||||||||..||||.::||.|||||::||...:....|:.|||:|:|:.|.:..||.|::||
  Fly    87 GVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADI 151

  Fly   149 LASKTFDWKSFTIAYER--SSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKF 211
            :  :.|.|:.|||.|:.  :....|||.:|..:::|...:::::|.:.||:|::||.|..  |:.
  Fly   152 V--QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRG--ERR 212

  Fly   212 VLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYV--- 273
            |:|||..::||:::|:|..:.:||.:||:|||||:|:...::...:.:.|.||.....|..|
  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPD 277

  Fly   274 PPPV---------HDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFY-----IPN 324
            |||.         .|.| |:::|...|  :|...|::|::.||..:....|   .||     :|.
  Fly   278 PPPYSLPYGYVTQRDNI-VYESSDPPR--TLIHDLIHDALQLFAQSWRNAS---FFYPDRMVVPR 336

  Fly   325 FSC-----GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTH 384
            .:|     |...|..|..|...||. |..:....|:|..||.:.||||..||:|||:|:......
  Fly   337 ITCDFAASGGRTWAMGRYLARLMKG-TSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIA 400

  Fly   385 IWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGN 449
            ||:...|:...                 |.:..:||.:.|.||||:|.||||:.|....::..||
  Fly   401 IWDPRGQITQL-----------------NVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGN 448

  Fly   450 ERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQ 514
            ..::|||||||..:|:...|::.|.||.|.:||..|..|.:|:|||.::|:|:|.:|||||||||
  Fly   449 ALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQ 513

  Fly   515 ARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQ 579
            ||::.|||||||||||:|||:||.|..:..:.|:|.|:..|||::::|::.:..|......||.:
  Fly   514 ARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISK 578

  Fly   580 YEWDQPVENVNREME-RQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQT 643
            .:|:.| ...||:.| .:|.|.:.|..||.:.|::..|||:|||...:|:..|.|||||::|:.:
  Fly   579 MDWENP-HPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANS 642

  Fly   644 YIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPD 708
            |.|.||||:||||:.|.|.:|.||..|.||:||||.||:|....::||:|..|:|:|.|.:..|.
  Fly   643 YTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPS 707

  Fly   709 AFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNL 773
            |:||:|.||||||:.::|.|.||||||.|:|:.::||:|..:||.||||||.||||..|::||||
  Fly   708 AYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNL 772

  Fly   774 SVGILRLSERGELFKLRNKWF-NSNESTCDSNVPTIDDGQFDM--DSVGGLFVVLIVGVVVGLVI 835
            ||.||:|||||||:.|:.||: |.|.|..:...|   |...||  :.:.|:|..|..|:::..:|
  Fly   773 SVAILKLSERGELYDLKQKWWKNPNASCFEEPDP---DATPDMTFEELRGIFYTLYAGILIAFLI 834

  Fly   836 GVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSAS 900
            |:.|||.:||:::::|::....|.|.|..||:..|..|||:..........:|...||::    |
  Fly   835 GITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDK----S 895

  Fly   901 SAKKKKKTRRI 911
            ..:..|.:||:
  Fly   896 LDRTPKSSRRV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	144/396 (36%)
		ANF_receptor	41..378	CDD:279440	133/366 (36%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	187/374 (50%)
		Lig_chan	555..822	CDD:278489	127/270 (47%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	143/391 (37%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	23/90 (26%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	187/371 (50%)
		Lig_chan	554..828	CDD:278489	129/277 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449681
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000