Protein Alignment GluRIIB and GluRIIC

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 921
• Identity: 370/921 - (40%)
• Similarity: 552/921 - (59%)
• Gaps: 73/921 - (7%)

  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAIN-PALK-----LDAIKRYVTVDDSIVLQDISCDLIGS 83
            |.|||.|:|.|::|...|   :..||||| |..:     ...|||....|.|:.:|:.:||||.:
  Fly    25 INIGAFFYDDELELEKEF---MTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDN 86

  Fly    84 GVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDI 148
            |||||||||||..||||.::||.|||||::||...:....|:.|||:|:|:.|.:..||.|::||
  Fly    87 GVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADI 151

  Fly   149 LASKTFDWKSFTIAYER--SSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKF 211
            :  :.|.|:.|||.|:.  :....|||.:|..:::|...:::::|.:.||:|::||.|..  |:.
  Fly   152 V--QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRG--ERR 212

  Fly   212 VLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYV--- 273
            |:|||..::||:::|:|..:.:||.:||:|||||:|:...::...:.:.|.||.....|..|
  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPD 277

  Fly   274 PPPV---------HDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFY-----IPN 324
            |||.         .|.| |:::|...|  :|...|::|::.||..:....|   .||     :|.
  Fly   278 PPPYSLPYGYVTQRDNI-VYESSDPPR--TLIHDLIHDALQLFAQSWRNAS---FFYPDRMVVPR 336

  Fly   325 FSC-----GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTH 384
            .:|     |...|..|..|...||. |..:....|:|..||.:.||||..||:|||:|:......
  Fly   337 ITCDFAASGGRTWAMGRYLARLMKG-TSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIA 400

  Fly   385 IWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGN 449
            ||:...|:...                 |.:..:||.:.|.||||:|.||||:.|....::..||
  Fly   401 IWDPRGQITQL-----------------NVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGN 448

  Fly   450 ERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQ 514
            ..::|||||||..:|:...|::.|.||.|.:||..|..|.:|:|||.::|:|:|.:|||||||||
  Fly   449 ALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQ 513

  Fly   515 ARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQ 579
            ||::.|||||||||||:|||:||.|..:..:.|:|.|:..|||::::|::.:..|......||.:
  Fly   514 ARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISK 578

  Fly   580 YEWDQPVENVNREME-RQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQT 643
            .:|:.| ...||:.| .:|.|.:.|..||.:.|::..|||:|||...:|:..|.|||||::|:.:
  Fly   579 MDWENP-HPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANS 642

  Fly   644 YIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPD 708
            |.|.||||:||||:.|.|.:|.||..|.||:||||.||:|....::||:|..|:|:|.|.:..|.
  Fly   643 YTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPS 707

  Fly   709 AFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNL 773
            |:||:|.||||||:.::|.|.||||||.|:|:.::||:|..:||.||||||.||||..|::||||
  Fly   708 AYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNL 772

  Fly   774 SVGILRLSERGELFKLRNKWF-NSNESTCDSNVPTIDDGQFDM--DSVGGLFVVLIVGVVVGLVI 835
            ||.||:|||||||:.|:.||: |.|.|..:...|   |...||  :.:.|:|..|..|:::..:|
  Fly   773 SVAILKLSERGELYDLKQKWWKNPNASCFEEPDP---DATPDMTFEELRGIFYTLYAGILIAFLI 834

  Fly   836 GVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSAS 900
            |:.|||.:||:::::|::....|.|.|..||:..|..|||:..........:|...||::    |
  Fly   835 GITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDK----S 895

  Fly   901 SAKKKKKTRRI 911
            ..:..|.:||:
  Fly   896 LDRTPKSSRRV 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	142/390 (36%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	187/374 (50%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	144/396 (36%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	187/371 (50%)
		Lig_chan	554..827	CDD:459656	129/276 (47%)