DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Ir7c

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	126/724 - (17%)
Similarity:	244/724 - (33%)	Gaps:	174/724 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 HLIRLQHILAWKQLHKAG------IKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVIN 226
            |.:.|.:.|.|...:..|      :.:.:|....:.|    |::|                |:|:
  Fly     7 HNVSLVYALVWAIDNYYGMATSTPLAVVQFPTSRESR----RLHN----------------DLID 51

  Fly   227 ASIGYNM-TGSFNHLF------LTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVF 284
            |::|.:. ||....|.      :|..||.                         |||
  Fly    52 AALGRSSGTGRIQFLLEDDRVEMTETDTD-------------------------PPP-------- 83

  Fly   285 DNSVDTR------FSSLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGFWQPGPRLVEQMK 343
            .:.:..|      ..||.|   |..:.::.|.|....:|.||::..::          .|.:|..
  Fly    84 PSGLTGRPIAIWFLDSLRS---YFRLEMYLNQLGSPYKRNGFFLVIYT----------GLEDQPM 135

  Fly   344 QITPKMVKPPFKTQRLQINADGQRE-DFNLEVYNPI----IDRVTHIWNKEFQLVDFEKLRENST 403
            :....|.:.......|.:|...||: ..:|..|.|.    ......::...||.:.........|
  Fly   136 ESLKIMFRRLLNMYVLNVNVFLQRDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLAAPANGFGLT 200

  Fly   404 QALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECK 468
            :.|..::|.|...     ....|||...:||....::|:   ..|.....|....:...||:...
  Fly   201 KPLFPRKLTNMHG-----CEMVVATFEHRPYVIIEDDPK---TPGGRSIHGIEGLIFRSLAERMN 257

  Fly   469 FDFNFEPVRDNKYGSY--DANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGI 531
            |.......:|...|..  |.|   :.||::.::|....:.......::||..::..:..:....|
  Fly   258 FTIKLVEQKDKNRGEILPDGN---FTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI 319

  Fly   532 SILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQ 596
             :|........:.:.....|:...:|..:::: :|..|.||...:|..
  Fly   320 -VLVVPSGGSISPMGRLTRPFRYIIWSCILVS-LIFGFVLICLLKITA----------------- 365

  Fly   597 NIWHLSNALWLVLG-----SMLNQGCDLLPRGLPM--------RLLTAFWWIFALLISQTYIAKL 648
                |.....||||     ..:.....|| .||.:        |.:...|.:..|::...|..:|
  Fly   366 ----LPGLRNLVLGRRNRLPFMGMWASLL-GGLALYNPQRNFARYILVMWLLQTLILRAAYTGQL 425

  Fly   649 AAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKN 713
            ...:...::...|.||.:::.:: .:|..:  .|....|.:|..|.|   ::.:||.:...:...
  Fly   426 YLLLQDVEMRSPIKSLSEVLAKD-YEFRIL--PALRTIFKDSMPTTN---FHAVLSLEESLYRLR 484

  Fly   714 NEE--GVDRVKLSKGTYAFLMETTNLQYYVQ---RNCELTQIGESFGEKHYGIAVPL------NA 767
            :|:  |:        |.|.|..|.| |:..:   ....||.:.:..      :..||      ::
  Fly   485 DEDDPGI--------TVALLQPTVN-QFDFRSGPNKRHLTVLPDPL------MTAPLTFYMRPHS 534

  Fly   768 DFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVG 832
            .|:..:...|:.:...|.:.:.|..:.:..:..  |....::.....:..:.|:||......:|.
  Fly   535 YFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRV--SKRRNLEPKPLSIWRLSGIFVCCAGLYLVA 597

  Fly   833 LVIGVAEFL 841
            |::.:.|.|
  Fly   598 LIVFILEIL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	44/248 (18%)
		ANF_receptor	41..378	CDD:279440	41/229 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	70/398 (18%)
		Lig_chan	555..822	CDD:278489	49/290 (17%)
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	14/67 (21%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	51/295 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740