DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Ir7b

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	91/516 - (17%)
Similarity:	186/516 - (36%)	Gaps:	109/516 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 KRLQNKEDFSQKPIRY-----TVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECK 468
            ||..:::.|..|...:     |.||....||..||.       :|:..|.|....|:..:|:...
  Fly   192 KRWASQDYFPSKLGNFYGCLLTCATWEDMPYLVWRP-------DGSGSFVGIEGALLQFMAENLN 249

  Fly   469 FD-----FNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDF---TVP 525
            |.     .|.|.|.        |..||...|..::..::|...:.......:..|.:.:   |..
  Fly   250 FTVGLYWMNKEEVL--------ATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYY 306

  Fly   526 FMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVN 590
            ||...:.:.:.:......:..:|  |:...:|..:.:.:::....|:...|     |..     :
  Fly   307 FMSHIMLVTNLQSAYSAYEKLSF--PFTPLLWRAIGLVLILACLLLMLLVR-----WRH-----H 359

  Fly   591 REMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSS 655
            .|:.|...:.|   |.|.:|..|..  ..:|:..|.||: ...|:||.|:           :.|.
  Fly   360 HELPRNPYYEL---LVLTMGGNLED--RWVPQRFPSRLV-LLTWLFATLV-----------LRSG 407

  Fly   656 KIAGDIGSLHDLVDQNKVQ-FGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPD------AFTKN 713
            ..:|....|.....:|..| ...:.....::..:|.|:.       ::|:..|:      .:.:.
  Fly   408 YQSGMYQLLRQDTQRNPPQTISEVLAQHFTIQLAEVNEA-------RILASLPELRPEQLVYLEG 465

  Fly   714 NE-EGVDRVKLSKGTYAFLMETTNLQYY--------VQRNCEL------TQIGESFGEKHYGIAV 763
            :| :....:....|:.|.:...|..:|:        :.|...|      ||....:..:|..:..
  Fly   466 SELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVG 530

  Fly   764 PLNADFRSNLSVGILR---------LSERGE-LFKLRNKWFNS----------NESTCDSNVPTI 808
            .||...:...:.|.|.         :.|:.| :.::.:..:::          :||..|..|..:
  Fly   531 VLNKQIQHAHTHGFLEHWTRQYVSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPV 595

  Fly   809 DDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLA-LKAEFYFVIR 868
            ......|..:..||.:::...:..:|:.|.|.|  :.||.:::.:..|.: :|.:...::|
  Fly   596 RQNVLSMRELAALFWLILWANLGAVVVFVLELL--LPRIKLRKILRKMKSDIKKQISKLVR 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	71/417 (17%)
		Lig_chan	555..822	CDD:278489	49/308 (16%)
Ir7b	NP_572410.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462678
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840