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Protein Alignment GluRIIB and Gria2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001077280.1	Gene:	Gria2 / 29627	RGDID:	61862	Length:	883	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	241/889 - (27%)
Similarity:	408/889 - (45%)	Gaps:	128/889 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GANEDTLVIKIGAIFFDT-EMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDL 80
            ||:::....::|.:.|.| |.:|..                .:|.::    |.:|..:.:..|..
  Rat    36 GADQEYSAFRVGMVQFSTSEFRLTP----------------HIDNLE----VANSFAVTNAFCSQ 80

  Fly    81 IGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQF--DWHPQQSNRERMNHQLTVNVAPMELFLSA 143
            ...||.||||...|.:.:.:...|   |..|:.|  ...|...     .|...:.:.|   .|..
  Rat    81 FSRGVYAIFGFYDKKSVNTITSFC---GTLHVSFITPSFPTDG-----THPFVIQMRP---DLKG 134

  Fly   144 AFSDILASKTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIKMQEF---ERGDDYRILWK 202
            |...::  :.:.|..|...|:....|..||.:|   |.|:.....|.:...   ::.:.||.|::
  Rat   135 ALLSLI--EYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQ 197

  Fly   203 RINNAREKFVLLDCPSDILVDVIN--ASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGF 255
            .:...:|:.|:|||..|.:.|:::  .:||.::.|  .|..:.||   |..|       :.:.||
  Rat   198 DLELKKERRVILDCERDKVNDIVDQVITIGKHVKG--YHYIIANLGFTDGDLLKIQFGGANVSGF 260

  Fly   256 YSRDFTVAVAAVRIRTYVP------PPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL--- 311
            ...|:..::.:..|..:..      |..|           |......|.|.||::.:...|.
  Rat   261 QIVDYDDSLVSKFIERWSTLEEKEYPGAH-----------TATIKYTSALTYDAVQVMTEAFRNL 314

  Fly   312 ----LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDF 370
                :|||:|  .|..:.|.:..   |..|..:...:||:..:.:     :..::.:.:|:|.::
  Rat   315 RKQRIEISRRGNAGDCLANPAVP---WGQGVEIERALKQVQVEGL-----SGNIKFDQNGKRINY 371

  Fly   371 NLEVY-----NPIIDRVTHIWNK-EFQLVDFEKLRE-NSTQALKQKRLQNKEDFSQKPIRYTVAT 428
            .:.:.     .|   |....|:: :..:|...:|.. |.|..|:.|.:             .|.|
  Rat   372 TINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDTSGLENKTV-------------VVTT 420

  Fly   429 RVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDG 493
            .:..||...::..|.:  |||||:|||.|||...:|:.|.|.:....|.|.|||:.||:|..|:|
  Rat   421 ILESPYVMMKKNHEML--EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNG 483

  Fly   494 IIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558
            ::.:|:...|.|.|..||||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:
  Rat   484 MVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE---MERQNIWHLSNALWLVLGSMLNQGCDLL 620
            .::.|.:..:..|....|...|||........||   .|..|.:.:.|:||..||:.:.||||:.
  Rat   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDIS 613

  Fly   621 PRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSV 685
            ||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..
  Rat   614 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKE 678

  Fly   686 YFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQ 749
            :|..|........|..|.|.:|..|.:...|||.||:.|||.||:|:|:|..:|..||. |:..:
  Rat   679 FFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMK 743

  Fly   750 IGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTC-----DSNVPTID 809
            :|.:...|.||||.|..:...:.:::.:|:|:|:|.|.||:|||: .::..|     ||...|
  Rat   744 VGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKEKT-- 805

  Fly   810 DGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853
             ....:.:|.|:|.:|:.|:.:.:::.:.||.:..:..:.:.|:
  Rat   806 -SALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKV 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.