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Protein Alignment GluRIIB and GRIN2D

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	979	Identity:	207/979 - (21%)
Similarity:	369/979 - (37%)	Gaps:	218/979 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QFLVLLALAIASGANED---------------------TLVIKIGAIFFDTEMKLADAFSAALEE 48
            :.|:|||||.||...|:                     ..::..|..:.....:|..|.:||:.
Human    15 KMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVR- 78

  Fly    49 VNAINPALKLDAIKRYVTVDD--SIVLQDISCDLIGSGV---AAIFGPSSKTN--SDIVEVLCNM 106
                :|.|.:..:...:...|  |:|||  .|||: ||:   ..:|...|:..  :.|::.|...
Human    79 ----SPGLDVRPVALVLNGSDPRSLVLQ--LCDLL-SGLRVHGVVFEDDSRAPAVAPILDFLSAQ 136

  Fly   107 TGIPHLQFDWHPQQSNRERMNHQLTVNVAPME---LFLSAAFS---------DILASKTFDWKSF 159
            |.:|.:            .::....:.:.|.|   .||....|         ::|  :.:||.||
Human   137 TSLPIV------------AVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVL--EEYDWTSF 187

  Fly   160 TIAYERS-SHLIRLQHI--------LAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLD 215
            .....|: .|...|.:|        :.|:  |:..:.:   :.|....:|..::.:...:..||.
Human   188 VAVTTRAPGHRAFLSYIEVLTDGSLVGWE--HRGALTL---DPGAGEAVLSAQLRSVSAQIRLLF 247

  Fly   216 CPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYS----------RDFTVAVAAVRIR 270
            |..:....|..|:....:|||....|:  :...|:|..|..:          ......:.|||..
Human   248 CAREEAEPVFRAAEEAGLTGSGYVWFM--VGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSA 310

  Fly   271 TYVPPPVHDEIDVFDNSVDTRFSSLGSQLV---YDSIVLFYNALLEISQRPGFYIPNFSC-GRGF 331
            .:     .|::        .|..:.|..:|   ..:::..|..|.|:..         .| .:..
Human   311 GW-----RDDL--------ARRVAAGVAVVARGAQALLRDYGFLPELGH---------DCRAQNR 353

  Fly   332 WQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHI---WNKEFQLV 393
            ...|..|......||       :..:....|.||...:.:|.|.:...||...:   |
Human   354 THRGESLHRYFMNIT-------WDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSW------- 404

  Fly   394 DFEKLRENSTQALKQKRLQNKEDFSQKPI----RYTVATRVGKPYF------------------- 435
                  |..|..||.........|.| |:    ..||||...:|:.
Human   405 ------EQQTLRLKYPLWSRYGRFLQ-PVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPC 462

  Fly   436 ------SWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGI 494
                  :....|:....| ....:|:.:|::..||....|.::...|.:.|:|......  |:|:
Human   463 RSQLNRTHSPPPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGV--WNGM 524

  Fly   495 IRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL---SYKEPPPKADIYAFLNPYNAEV 556
            |.::....|.:.|..|||.:.|..:|||:|||::.|||::   |.....|.    |||.||:..|
Human   525 IGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS----AFLEPYSPAV 585

  Fly   557 W--LFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMER-----QNIWHLSNALWLVLGSMLN 614
            |  :|||...::.....||       |:..|| ..||.:..     .:.:.:..::||:...:.|
Human   586 WVMMFVMCLTVVAVTVFIF-------EYLSPV-GYNRSLATGKRPGGSTFTIGKSIWLLWALVFN 642

  Fly   615 QGCDL-LPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQN------K 672
            ....: .|||...:::...|..||::...:|.|.||||:...:....:..|.|...|.      .
Human   643 NSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPP 707

  Fly   673 VQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNL 737
            ::|||:..|:|     |.|...|   :..|.|:.........||.:.::|..| ..||:.:...|
Human   708 LKFGTVPNGST-----EKNIRSN---YPDMHSYMVRYNQPRVEEALTQLKAGK-LDAFIYDAAVL 763

  Fly   738 QYYVQRN--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNE 798
            .|..:::  |:|..||..  |....||||:...:.::..:.:.:|:.....|:..|...|.:
Human   764 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLS--- 825

  Fly   799 STCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFL--WHVQR-ISVKEKIPPMLALK 860
            ..|.::...:...:.|:|::.|:|.:|:|.:.:.|::...|.|  |.::. :....::..:||..
Human   826 GICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFS 890

  Fly   861 AEFY 864
            ...|
Human   891 RGMY 894

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.