back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GRIN2B

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	926	Identity:	196/926 - (21%)
Similarity:	364/926 - (39%)	Gaps:	179/926 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLVLLALAIASG---ANEDTLVIKIGAIFFDT--EMKLADAFSAALEEVNAINPALKLDAIKRYV 65
            :|||..||::..   :.:....|.|..|...|  |:.:.||...  ::.:.::...:::.:....
Human    13 WLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEK--DDFHHLSVVPRVELVAMNE 75

  Fly    66 TVDDSIVLQDISCDLIG----SGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERM 126
            |...||:.:  .|||:.    .||........:..:.|::.:...|..|.|...........::.
Human    76 TDPKSIITR--ICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKD 138

  Fly   127 NHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTI------AYERSSHLIRL---QHILAWKQLH 182
            ...:.....|.....::...:|:  :.:||..|:|      .|:...:.||.   ...:.| :|.
Human   139 ESSMFFQFGPSIEQQASVMLNIM--EEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGW-ELE 200

  Fly   183 KAGIKMQEFERGDDYRILWKRINNAREK----FVLLDCPSD---ILVDVINA--SIGYNMTGSFN 238
            :..:.....:.||      .:|.|..:|    .:||.|..:   .:.:|.|:  ..||..|....
Human   201 EVLLLDMSLDDGD------SKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVP 259

  Fly   239 HLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDS 303
            .|...:.||        ...:|...:.:|            ..|.:|..:..|        |.|.
Human   260 SLVAGDTDT--------VPAEFPTGLISV------------SYDEWDYGLPAR--------VRDG 296

  Fly   304 IVLFYNALLEISQRPGFY-IPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQR 367
            |.:...|..::.....|. .|..||    :....:.:.|...:...::...|:.:.|..:.||.:
Human   297 IAIITTAASDMLSEHSFIPEPKSSC----YNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQ 357

  Fly   368 EDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNK---------EDFSQKPIR 423
            ....|         |..:.|||.:   :|::.:     .|.|.||.|         |...|:...
Human   358 MHPKL---------VIILLNKERK---WERVGK-----WKDKSLQMKYYVWPRMCPETEEQEDDH 405

  Fly   424 YTVATRVGKPYF---------------------------SWREEPEGVHYEGNERFEGYAVDLIY 461
            .::.|....|:.                           ...|||..:    .:..:|:.:|::.
Human   406 LSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYI----KKCCKGFCIDILK 466

  Fly   462 MLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPF 526
            .:::..||.::...|.:.|:|.....|  |:|:|.:::...|.:.:..|||.:.|..||||:|||
Human   467 KISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPF 529

  Fly   527 MQLGISIL---SYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVEN 588
            ::.|||::   |.....|.    |||.|::|:||:.:.:.::|.:...:|.     :|:..|| .
Human   530 IETGISVMVSRSNGTVSPS----AFLEPFSADVWVMMFVMLLIVSAVAVFV-----FEYFSPV-G 584

  Fly   589 VNREMERQN-----IWHLSNALWLVLGSMLNQGCDLL-PRGLPMRLLTAFWWIFALLISQTYIAK 647
            .||.:....     .:.:..|:||:.|.:.|....:. |:|...:::.:.|..||::...:|.|.
Human   585 YNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   648 LAAFITSSKIAGDIGSLHDLVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFK 706
            ||||:...:....:..|.|...|.      ..:|||:..|:|     |.|..:|....:..:.
Human   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST-----ERNIRNNYAEMHAYMG-- 707

  Fly   707 PDAFTKNNEEGVDRVKLSKGT---YAFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGIAVP 764
                 |.|:.|||...||..|   .||:.:...|.|...|:  |:|..||..  |....||||:.
Human   708 -----KFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQ 767

  Fly   765 LNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGV 829
            .::.::..:.:.||:|...||:.:|...|..   ..|.:....:...|.|:|::.|:|.:|...:
Human   768 KDSGWKRQVDLAILQLFGDGEMEELEALWLT---GICHNEKNEVMSSQLDIDNMAGVFYMLGAAM 829

  Fly   830 VVGLVIGVAEFLWHVQ 845
            .:.|:..:.|.|::.|
Human   830 ALSLITFICEHLFYWQ 845

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.