DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GRIK4

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	877	Identity:	253/877 - (28%)
Similarity:	412/877 - (46%)	Gaps:	83/877 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLVLLALAIASGANEDTLVIKIGAIFFD-TEMKLADAFSAALEEVNAINPA-LKLDAIKRYVTVD 68
            :||::|.:..|        ::|.||..| .|....:..|..|.: |.||.| .:|...|  |.||
Human    14 WLVMVACSPHS--------LRIAAILDDPMECSRGERLSITLAK-NRINRAPERLGKAK--VEVD 67

  Fly    69 DSIVLQD-------ISCDLIGSGVAAIFGPSSK-TNSDIVEVLCNMTGIPHLQFDWHPQQSNRER 125
            ...:|:|       ..|.::..||.|:.||||. .:|.|:..:|....:||  |...|::..:.:
Human    68 IFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFVKFQ 130

  Fly   126 MNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQE 190
            .....|:|:.|....:|.|.:.||  ..|:..:..:...::..|:.|:.:|....:.|..:.::.
Human   131 FQRFTTLNLHPSNTDISVAVAGIL--NFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRM 193

  Fly   191 FERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF 255
            .:...|...|.|.|.:.:...:::...:.:...::..:....|..::.....|||:..|..:|..
Human   194 LDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSL 258

  Fly   256 YSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFS-----------SLGSQLVYDSIVLFYN 309
            .  |..|.:....|..    ..|.....|..|::..:.           :|.|.|::|::.....
Human   259 V--DDRVNILGFSIFN----QSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVT 317

  Fly   310 ALLEISQRPGFYIPNFSCGRG-FWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLE 373
            |:.|:::.....:...|||.. .||.|..|:..:     :||:....|..::.|:.|||.::.|:
Human   318 AVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYL-----RMVELEGLTGHIEFNSKGQRSNYALK 377

  Fly   374 VYNPIIDRVTHI--WN-KEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYF 435
            :.....:....|  |: .|...:|......|.:..|....|             .|.|.:..||.
Human   378 ILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTL-------------VVTTILENPYL 429

  Fly   436 SWREEPEGVH--YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQL 498
            ..:    |.|  .|||:|:||:.||::..||:..:|::....|.|..||..:|| ..|.|::.:|
Human   430 MLK----GNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEAN-GTWTGMVGEL 489

  Fly   499 IDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIA 563
            |...|.:.:..||||..|..|:||:.|||.||||||.......|...::||:|::..||||:::|
Human   490 IARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLA 554

  Fly   564 MMITAFALIFTGRIDQYEWDQPVENVNREME-RQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMR 627
            .:..:..|....|:..|||..|......... ..|.:.|.|:||..:|..:.||..:.||.|..|
Human   555 YLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTR 619

  Fly   628 LLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESND 692
            .::..||.|.|:|..:|.|.||||:|..::...|.|:.||.||..:::|||.||::..:|..|..
Human   620 CVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRY 684

  Fly   693 TDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEK 757
            ...:..||.|.|.:|..|.|:.|||:.||..|  .||||:|:|..:||.||||.|||||.....|
Human   685 QTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQRNCNLTQIGGLLDTK 747

  Fly   758 HYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ---FDMDSVG 819
            .|||.:|:.:.||....:.||:|.|...|..|:.||:...:  |    |..:|.:   ..|:::|
Human   748 GYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGK--C----PKEEDHRAKGLGMENIG 806

  Fly   820 GLFVVLIVGVVVGLVIGVAEFLWHVQRISVKE 851
            |:|||||.|::|.:.:.:.||||.::.....|
Human   807 GIFVVLICGLIVAIFMAMLEFLWTLRHSEATE 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	85/391 (22%)
		ANF_receptor	41..378	CDD:279440	77/357 (22%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	142/375 (38%)
		Lig_chan	555..822	CDD:278489	99/270 (37%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	85/391 (22%)
		ANF_receptor	43..382	CDD:279440	77/356 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	143/389 (37%)
		Lig_chan	547..816	CDD:278489	104/276 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850