DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GRIK3

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	915	Identity:	266/915 - (29%)
Similarity:	443/915 - (48%)	Gaps:	103/915 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDA--IKRYVTV---------------DDSI 71
            ||:||.||     :.||..:|  :.:||...|.:..|  |.|..|:               .||.
Human    35 VIRIGGIF-----EYADGPNA--QVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSF 92

  Fly    72 VLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQSNRERMNHQLTVNVA 135
            .....:||.:..||.||||||..:.::.|:.:||...:||:|..| |....|::    ...||:.
Human    93 EATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKD----TFYVNLY 153

  Fly   136 PMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFE-RGDDYRI 199
            |....||.|..|::  :...|:|.|:.|:.|:.|||||.::.....:...:|:::.. ..||.|.
Human   154 PDYASLSHAILDLV--QYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRP 216

  Fly   200 LWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF-YSRDFTVA 263
            |.|.:...||..::.||...:...::..::...|...:.|...|.||.:...::.: ||   .|.
Human   217 LLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYS---GVN 278

  Fly   264 VAAVRIRTYVPPPVHDEIDVFD----NSVDTRFSSLGSQLVYDSIVLFYNALLEIS---QR-PGF 320
            :...||.....|.|...::.:.    .:.....|.|...::.....|.|:|:..:|   || |..
Human   279 LTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQM 343

  Fly   321 YIPNFSCGR-GFWQPGPRLVEQMKQITPKMVKPPFKTQRLQIN-ADGQREDFNLEVYNPIIDRV- 382
            .:.:..|.| ..|:.|.|.:..:|:...:.:     |.|:..| ..|.|.||:|::.:...|.:
Human   344 TVNSLQCHRHKAWRFGGRFMNFIKEAQWEGL-----TGRIVFNKTSGLRTDFDLDIISLKEDGLE 403

  Fly   383 -THIWNKE--FQLVDFEKLR-ENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEG 443
             ..:|:..  ..:.:..|.| .|.|.:|..:.|             .|.|.:.:|:..:|:....
Human   404 KVGVWSPADGLNITEVAKGRGPNVTDSLTNRSL-------------IVTTVLEEPFVMFRKSDRT 455

  Fly   444 VHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGIC 508
            ::  ||:|||||.:||:..||....|.:....|.|.|||:.| :..:|:|::::|||:.|.:.:.
Human   456 LY--GNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVA 517

  Fly   509 DLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIF 573
            .||||..|...:||:.|||.||:|||..|.......:::||||.:.::|::|::|.:..:..|..
Human   518 PLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFV 582

  Fly   574 TGRIDQYEW-DQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFA 637
            ..|...||| |....|...|:...| :.|.|:.|..:||::.||.:|:|:.|..|::...||.|.
Human   583 IARFSPYEWYDAHPCNPGSEVVENN-FTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFT 646

  Fly   638 LLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKM 702
            |:|..:|.|.||||:|..::...|.|..||..|.|:::|.::.|||..:|.:|..:.....| ..
Human   647 LIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW-AF 710

  Fly   703 LSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNA 767
            :|.||.|..||||||:.|...:  .||.|||:|.::|..||||.|||||.....|.|||..|:.:
Human   711 MSSKPSALVKNNEEGIQRALTA--DYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGS 773

  Fly   768 DFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVG 832
            .:|..:::.||:|.|..:|..::.||:..:....:.|.   :.....:..:||:|:||..|:|:.
Human   774 PYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENK---EASALGIQKIGGIFIVLAAGLVLS 835

  Fly   833 LVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLT------RKP-------------LHT 878
            :::.|.||::.:::.:.:|:......:..|    |||.||      .||             :||
Human   836 VLVAVGEFVYKLRKTAEREQRSFCSTVADE----IRFSLTCQRRVKHKPQPPMMVKTDAVINMHT 896

  Fly   879 YRQSR 883
            :...|
Human   897 FNDRR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	99/400 (25%)
		ANF_receptor	41..378	CDD:279440	91/366 (25%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	136/373 (36%)
		Lig_chan	555..822	CDD:278489	91/267 (34%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	101/402 (25%)
		ANF_receptor	55..398	CDD:279440	89/356 (25%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	137/387 (35%)
		Lig_chan	564..832	CDD:278489	94/274 (34%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750