Protein Alignment GluRIIB and GRID1

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 974
• Identity: 224/974 - (22%)
• Similarity: 405/974 - (41%)
• Gaps: 176/974 - (18%)

  Fly    24 VIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDS----IVLQDISCDLIGSG 84
            :|.|||||.:...|....|..|:.:::..:..|:.:.|...:.|.::    ..:|: :|||:..|
Human    23 IIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQE-ACDLMTQG 86

  Fly    85 VAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAP-MELFLSAA---- 144
            :.|:...:...:::.::.|.:...||||....:|..|.|...:    :|.:| .|.:..|:
Human    87 ILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACH----LNPSPDGEAYTLASRPPV 147

  Fly   145 -FSDILASKTFD--WKSFTIAYERSSHLIRLQHILAWKQLHKAG--IKMQEFERGDDY------- 197
             .:|::.....:  |:.|.:.|:....:..||..|  .|..:.|  :.:|:.::...:
Human   148 RLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFL--DQASRLGLDVSLQKVDKNISHVFTSLFT 210

  Fly   198 RILWKRINNARE---KFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTN---LDTHLSGIDGFY 256
            .:..:.:|..|:   :.:||..|.. ....||.::..|:....:|....|   .|..:  :|..:
Human   211 TMKTEELNRYRDTLRRAILLLSPQG-AHSFINEAVETNLASKDSHWVFVNEEISDPEI--LDLVH 272

  Fly   257 SRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSL--------------GSQLVYDSIVLF 307
            |     |:..:.:...:.|...|......|  :.|.|||              .:..:|||:::.
Human   273 S-----ALGRMTVVRQIFPSAKDNQKCTRN--NHRISSLLCDPQEGYLQMLQISNLYLYDSVLML 330

  Fly   308 YNAL-LEISQRPGFYIPNFSCGRGF---WQPGPRLVEQMKQ-----ITPKMVKPPFKTQRLQINA 363
            .||. .::..|....:.:.:|.|..   |..|..:::.:|:     :|..|
Human   331 ANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVM-------------- 381

  Fly   364 DGQREDFNLEVYNPIID------RVTHIWNKEFQLV---DFEKLRENSTQALKQ-KRLQNKEDFS 418
                 :|..:..||.:.      ..:..:.|:.:.:   |.||....|.|.... .|||.
Human   382 -----EFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQG----- 436

  Fly   419 QKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGS 483
               :...|.|.:.:|:....|...|    ..:|::|:::|::..||:...|.:......|.:||.
Human   437 ---LTLKVVTVLEEPFVMVAENILG----QPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGH 494

  Fly   484 YDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAF 548
            ...|| .|:|:|.:||...|.:.|..:|||..|.|||||:..:|...:.|| .|:|..|..|::.
Human   495 QLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL-IKKPEEKISIFSL 557

  Fly   549 LNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNI-WHLSNALWLVLGSM 612
            ..|::..||..:..|:.:....:....||      |.|...:....|.:. ..|.:|:|:|.|:.
Human   558 FAPFDFAVWACIAAAIPVVGVLIFVLNRI------QAVRAQSAAQPRPSASATLHSAIWIVYGAF 616

  Fly   613 LNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGT 677
            :.||.:.....:.||::...||:|.|::..:|.|.||||:|.|::...|.:..||..|.::.:||
Human   617 VQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGT 681

  Fly   678 IRGGATSVYFSESN----DTDNRMA--WNKMLSFKPDAFTKNN---------EEGVDRVKLSKGT 727
            :|..|...||....    :.|:..|  |.        ..:||.         .||:.:.|  ||.
Human   682 VRDSAVYEYFRAKGTNPLEQDSTFAELWR--------TISKNGGADNCVSSPSEGIRKAK--KGN 736

  Fly   728 YAFLMETTNLQY--YVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLR 790
            ||||.:...::|  ....:|.:|.||.|...|.||||:...:.:|...|..||.|.:.|:|..|:
Human   737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLK 801

  Fly   791 NKWFNSNESTCD--SNVPTIDDGQ-FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQR------ 846
            .||: .:...||  |:.....||: ..:.|..|:|.:|.:|:::..::...|..|:..|
Human   802 QKWW-PHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETP 865

  Fly   847 ----------------------ISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTST 888
                                  |:.|:..|..:.|.|.....:....|.:|...|:.::.|.||
Human   866 KEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVST 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	76/416 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	114/390 (29%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		85/448 (19%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	80/435 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	114/400 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954		224/974 (23%)