DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GRID1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	974	Identity:	224/974 - (22%)
Similarity:	405/974 - (41%)	Gaps:	176/974 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDS----IVLQDISCDLIGSG 84
            :|.|||||.:...|....|..|:.:::..:..|:.:.|...:.|.::    ..:|: :|||:..|
Human    23 IIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQE-ACDLMTQG 86

  Fly    85 VAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAP-MELFLSAA---- 144
            :.|:...:...:::.::.|.:...||||....:|..|.|...:    :|.:| .|.:..|:
Human    87 ILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACH----LNPSPDGEAYTLASRPPV 147

  Fly   145 -FSDILASKTFD--WKSFTIAYERSSHLIRLQHILAWKQLHKAG--IKMQEFERGDDY------- 197
             .:|::.....:  |:.|.:.|:....:..||..|  .|..:.|  :.:|:.::...:
Human   148 RLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFL--DQASRLGLDVSLQKVDKNISHVFTSLFT 210

  Fly   198 RILWKRINNARE---KFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTN---LDTHLSGIDGFY 256
            .:..:.:|..|:   :.:||..|.. ....||.::..|:....:|....|   .|..:  :|..:
Human   211 TMKTEELNRYRDTLRRAILLLSPQG-AHSFINEAVETNLASKDSHWVFVNEEISDPEI--LDLVH 272

  Fly   257 SRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSL--------------GSQLVYDSIVLF 307
            |     |:..:.:...:.|...|......|  :.|.|||              .:..:|||:::.
Human   273 S-----ALGRMTVVRQIFPSAKDNQKCTRN--NHRISSLLCDPQEGYLQMLQISNLYLYDSVLML 330

  Fly   308 YNAL-LEISQRPGFYIPNFSCGRGF---WQPGPRLVEQMKQ-----ITPKMVKPPFKTQRLQINA 363
            .||. .::..|....:.:.:|.|..   |..|..:::.:|:     :|..|
Human   331 ANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVM-------------- 381

  Fly   364 DGQREDFNLEVYNPIID------RVTHIWNKEFQLV---DFEKLRENSTQALKQ-KRLQNKEDFS 418
                 :|..:..||.:.      ..:..:.|:.:.:   |.||....|.|.... .|||.
Human   382 -----EFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQG----- 436

  Fly   419 QKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGS 483
               :...|.|.:.:|:....|...|    ..:|::|:::|::..||:...|.:......|.:||.
Human   437 ---LTLKVVTVLEEPFVMVAENILG----QPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGH 494

  Fly   484 YDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAF 548
            ...|| .|:|:|.:||...|.:.|..:|||..|.|||||:..:|...:.|| .|:|..|..|::.
Human   495 QLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL-IKKPEEKISIFSL 557

  Fly   549 LNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNI-WHLSNALWLVLGSM 612
            ..|::..||..:..|:.:....:....||      |.|...:....|.:. ..|.:|:|:|.|:.
Human   558 FAPFDFAVWACIAAAIPVVGVLIFVLNRI------QAVRAQSAAQPRPSASATLHSAIWIVYGAF 616

  Fly   613 LNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGT 677
            :.||.:.....:.||::...||:|.|::..:|.|.||||:|.|::...|.:..||..|.::.:||
Human   617 VQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGT 681

  Fly   678 IRGGATSVYFSESN----DTDNRMA--WNKMLSFKPDAFTKNN---------EEGVDRVKLSKGT 727
            :|..|...||....    :.|:..|  |.        ..:||.         .||:.:.|  ||.
Human   682 VRDSAVYEYFRAKGTNPLEQDSTFAELWR--------TISKNGGADNCVSSPSEGIRKAK--KGN 736

  Fly   728 YAFLMETTNLQY--YVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLR 790
            ||||.:...::|  ....:|.:|.||.|...|.||||:...:.:|...|..||.|.:.|:|..|:
Human   737 YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLK 801

  Fly   791 NKWFNSNESTCD--SNVPTIDDGQ-FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQR------ 846
            .||: .:...||  |:.....||: ..:.|..|:|.:|.:|:::..::...|..|:..|
Human   802 QKWW-PHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETP 865

  Fly   847 ----------------------ISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTST 888
                                  |:.|:..|..:.|.|.....:....|.:|...|:.::.|.||
Human   866 KEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVST 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	77/422 (18%)
		ANF_receptor	41..378	CDD:279440	69/386 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	114/390 (29%)
		Lig_chan	555..822	CDD:278489	81/287 (28%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		85/448 (19%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	80/433 (18%)
		ANF_receptor	41..400	CDD:279440	70/394 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	114/400 (29%)
		Lig_chan	564..841	CDD:278489	83/293 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954		224/974 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740