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Protein Alignment GluRIIB and GRIA4

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	900	Identity:	240/900 - (26%)
Similarity:	404/900 - (44%)	Gaps:	150/900 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IASGANEDTLVIKIGAIFFDTEMKLADAFSAAL----EEVNAINPALKLDAIKRYVTVDDSIVLQ 74
            :|.||...:  ::||.:|.....:...||..|:    ...||......|......:...:|..:.
Human    18 LAMGAFPSS--VQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVT 80

  Fly    75 DISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMEL 139
            :..|.....||.||||...|.:...:...|:...|..:...:..:..:      |..:.:.|.
Human    81 NAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGES------QFVLQLRPS-- 137

  Fly   140 FLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHIL------AWKQLHKAGIKMQEFERGDDYR 198
             |..|...:|  ..::|..|...|:.......||.|:      .|   |.:.|.::.| ....||
Human   138 -LRGALLSLL--DHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGW---HVSAICVENF-NDVSYR 195

  Fly   199 ILWKRINNAREKFVLLDCPSDILVDVIN--ASIGYNMTGSFNHLFLTNL---DTHL-------SG 251
            .|.:.::..:||..::||..:.|.:::.  .|:|.::.|  .|..:.||   |..|       :.
Human   196 QLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKG--YHYIIANLGFKDISLERFIHGGAN 258

  Fly   252 IDGFYSRDFTVAVAAVRI---------RTY----VPPPVHDEIDVFDNSVDTRFSSLGSQLVYDS 303
            :.||...||...: .:::         |.|    .||                  ...|.|.||.
Human   259 VTGFQLVDFNTPM-VIKLMDRWKKLDQREYPGSETPP------------------KYTSALTYDG 304

  Fly   304 IVLF---YNAL----LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRL 359
            :::.   :.:|    ::||:|  .|..:.|.:..   |..|..:...:||:..:.:     |..:
Human   305 VLVMAETFRSLRRQKIDISRRGNAGDCLANPAAP---WGQGIDMERTLKQVRIQGL-----TGNV 361

  Fly   360 QINADGQREDFNLEVY-----NPIIDRVTHIWNKEFQLVDFEKLRE--NSTQALKQKRLQNKEDF 417
            |.:..|:|.::.::|:     .|   |....||...:||..:.:..  |.|.|::.:.:
Human   362 QFDHYGRRVNYTMDVFELKSTGP---RKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTV------ 417

  Fly   418 SQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYG 482
                   .|.|.:..||..:::..|  .:|||:::|||.|||...:|:.....:....|.|.|||
Human   418 -------VVTTIMESPYVMYKKNHE--MFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYG 473

  Fly   483 SYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYA 547
            :.||:|..|:|::.:|:...|:|.|..||||..|..|:||:.|||.|||||:..|....|..:::
Human   474 ARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS 538

  Fly   548 FLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW-------------DQPVENVNREMERQNIW 599
            ||:|...|:|:.::.|.:..:..|....|...|||             |||          .|.:
Human   539 FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQP----------PNEF 593

  Fly   600 HLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSL 664
            .:.|:||..||:.:.||||:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|.
Human   594 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESA 658

  Fly   665 HDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYA 729
            .||..|.::.:||:..|:|..:|..|........|..|.|.:|..||:...|||.||:.|||.:|
Human   659 EDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFA 723

  Fly   730 FLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKW 793
            ||:|:|..:|..||. |:..::|.:...|.||:|.|..:..|:.:::.:|:|||.|.|.||:|||
Human   724 FLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKW 788

  Fly   794 FNSNESTCDSNVPTIDDGQFD------MDSVGGLFVVLIVGVVVGLVIGVAEFLW 842
            : .::..|...    |.|..|      :.:|.|:|.:|:.|:.:.:::.:.||.:
Human   789 W-YDKGECGPK----DSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 838

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.