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Protein Alignment GluRIIB and GRIA3

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	951	Identity:	258/951 - (27%)
Similarity:	421/951 - (44%)	Gaps:	147/951 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALE----EVNAINPALKLDAIKRYVT 66
            ||||..|..:.|...:|  |.||.:|....::...||..|::    ..|.......|:....::.
Human    17 FLVLGLLGHSHGGFPNT--ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLD 79

  Fly    67 VDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLT 131
            ..:|..:.:..|.....||.||||...:.:.:.:...|   |..|..|   ...|.....:.|..
Human    80 SSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFC---GALHTSF---VTPSFPTDADVQFV 138

  Fly   132 VNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILA------WKQLHKA--GIK- 187
            :.:.|.   |..|...:|..  :.|:.|...|:.......||.|:.      |:...::  .||
Human   139 IQMRPA---LKGAILSLLGH--YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKD 198

  Fly   188 MQEFERGDDYRILWKRINNAREKFVLLDCP----SDILVDVI---NASIGYNMTGSFNHLFLTNL 245
            :|||.|      :.:.::..:||..|:||.    :.||..|:   ..|.||       |..|.||
Human   199 VQEFRR------IIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGY-------HYMLANL 250

  Fly   246 ---DTHL-------SGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFS------- 293
               |..|       :.|.||            :|.....|.|...|..:....:..|.
Human   251 GFTDILLERVMHGGANITGF------------QIVNNENPMVQQFIQRWVRLDEREFPEAKNAPL 303

  Fly   294 SLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKM 349
            ...|.|.:|:|::...|.       :::|:|  .|..:.|.:..   |..|..:...:     ||
Human   304 KYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVP---WSQGIDIERAL-----KM 360

  Fly   350 VKPPFKTQRLQINADGQREDFNLEVYNPII--DRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQ 412
            |:....|..:|.:..|:|.::.::||...:  .|....||:..:.|.|...:.::..|..:.|
Human   361 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENR-- 423

  Fly   413 NKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVR 477
                      ...|.|.:..||..:::..|  ..|||||:|||.|||.|.:|:..:..:....|.
Human   424 ----------TIVVTTILESPYVMYKKNHE--QLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVG 476

  Fly   478 DNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPK 542
            |.|||:.|..|..|:|::.:|:...|.|.:..||||..|..|:||:.|||.|||||:..|....|
Human   477 DGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 541

  Fly   543 ADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE-------MERQNIWH 600
            ..:::||:|...|:|:.::.|.:..:..|....|...|||.  :|:.|.|       .:..|.:.
Human   542 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH--LEDNNEEPRDPQSPPDPPNEFG 604

  Fly   601 LSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLH 665
            :.|:||..||:.:.||||:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..
Human   605 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAE 669

  Fly   666 DLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAF 730
            ||..|.::.:||:..|:|..:|..|........|:.|.|.:|..|||...:||.||:.|||.:||
Human   670 DLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAF 734

  Fly   731 LMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWF 794
            |:|:|..:|..||. |:..::|.:...|.||:|.|..:..|:.:::.:|:|:|:|.|.||:|||:
Human   735 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWW 799

  Fly   795 NSNESTCDSNVPTIDD--GQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI---- 853
             .::..|.|......|  ....:.:|.|:|.:|:.|:.:.:::.:.||.:..:..|.:.|:
Human   800 -YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNT 863

  Fly   854 ---PPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYS 891
               .|..|...:.|            .|||:       ||:
Human   864 QNFKPAPATNTQNY------------ATYRE-------GYN 885

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.